MSACL Presenter Biography

Jennifer van Eyk
Advanced Clinical Biosystems Institute, Cedars Sinai

Dr. Van Eyk is a Professor of Medicine at Cedars-Sinai Medical Center, Director of the Basic Science Research in the Barbra Streisand Woman’s Hearth Center and Director of the Advance Clinical Biosystems Institute. Dr. Van Eyk’s lab specializes in developing robust technological pipelines to precisely quantify proteins, isoform and their post-translational modifications (PTM) in disease pathways. This includes understanding interplay between competing PTMs like O-GlcNAc and phosphorylation and multiple oxidative modifications. Her group uses automation in sample preparation to allow for high-throughput and robust MS analysis, which includes discovery and the novel approach, SWATH (DIA) that allows complete and reproducible analysis of 1000s of proteins in 100s of samples. As well, absolute quantification of key targets can be quickly and cost effectively via ultra sensitive ELISA platforms (e.g. Quanterix) or multiple reaction monitoring assays, a targeted MS-based quantitative method, for a tracking multidimensional signaling pathway interplay.