MSACL 2018 US: Preliminary Conference Program

Palm Springs, CALIFORNIA • January 21 - 25, 2018

With Thanks to Our Corporate Conference Sponsors:
Thermo Shimadzu 
Agilent  SCIEX Indigo 
PerkinElmer

Sunday

8:00
18:00
BADGE PICKUP
@ Renaissance Ballroom Foyer
8:00
12:00

PRE-CON SPONSOR WORKSHOPS

Agilent Technologies
Room 3

11:00
14:00
LUNCH ON OWN
@ Your Decision

Check out a downtown restaurant.
14:00
18:00

SHORT COURSES

COURSE START
Clinical MS 301
A Comprehensive Review of Clinical Mass Spectrometry Technology & Techniques, including Miniaturization
Jack Henion, PhD
Level: 2-3 (Intermediate - Advanced)
Location: Mesquite D
COURSE START
Data Science 101
Breaking up with Excel: A Newbie's Introduction to the R Statistical Programming Language
Daniel Holmes, MD & Stephen Master, MD, PhD
Level: 1-2 (Beginner - Intermediate)
Location: Room 2 (Catalina)
COURSE START
Data Science 201
Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling
Patrick Mathias, MD, PhD & Randall Julian, PhD
Level: 2 (Intermediate)
Location: Room 1 (Mojave Learning Center)
COURSE START
LC-MSMS 101
Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory
Judy Stone, PhD, Lorin Bachmann, PhD & Grace van der Gugten
Level: 1-2 (Beginner - Intermediate)
Location: Room 3 (Madera)
COURSE START
LC-MSMS 201
Understanding and Optimization of LC-MS/MS to Develop Successful Methods for Identification and Quantitation in Complex Matrices
Robert D. Voyksner, PhD
Level: 2 (Intermediate)
Location: Andreas
COURSE START
LC-MSMS 202
Practical LC-MS Maintenance and Troubleshooting
J. Will Thompson, PhD, Erik J. Soderblom, PhD & Chris Shuford, PhD
Level: 2 (Intermediate)
Location: Mesquite H
COURSE START
LC-MSMS 301
Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics
Russell Grant, PhD & Matthew Crawford
Level: 3 (Advanced)
Location: Room 4 (Pasadena)
COURSE START
MALDI 102
Practical Considerations for MALDI Imaging Mass Spectrometry
Michelle Reyzer, PhD
Level: 1-2 (Beginner - Intermediate)
Location: Snowcreek
COURSE START
MALDI 103
MALDI-MS Fundamentals and its Emerging Role in Pathology and Laboratory Medicine
Mark W. Duncan, PhD & Mari L. DeMarco, PhD
with Guest lecturers:
Zhen Zhao, Weill Cornell Medical School,
Fang Wu, University of Saskatchewan,
Dobrin Nedelkov, Isoformix Inc,
Jeff Spraggins, Vanderbilt, and
Clifton Fagerquist, USDA
Level: 1-2 (Beginner - Intermediate)
Location: Mesquite G
COURSE START
Metabolomics 201
Application of High Resolution Mass Spectrometry and Metabolomics in Clinical Analysis
Timothy Garrett, PhD & Erin Baker, PhD
Level: 2 (Intermediate)
Location: Mesquite F
COURSE START
Presentations 101
How to Maximize Your Influence Through Creating Compelling Presentations
Karen Mahooti, MBA
Level: 1-2 (Beginner - Intermediate)
Location: Chino A
COURSE START
Proteomics 201
Clinical Proteomics
Andy Hoofnagle, MD, PhD, Cory Bystrom, PhD & Chris Shuford, PhD
Level: 2-3 (Intermediate - Advanced)
Location: Room 5 (Sierra/Ventura)
COURSE START
Proteomics 202
Practical Proteomics Using the Skyline Software Ecosystem
Mike MacCoss, PhD, Brendan MacLean, Lindsay Pino, and Sandi Spencer
Level: 1-3 (Beginner -Advanced)
Location: Chino B
COURSE START
Sample Prep 201
Sample Preparation and Alternative Matrices for LC-MS Assays
William Clarke, PhD & Mark Marzinke, PhD
Level: Beginner / Intermediate
Location: Mesquite E
Every 0:50
for 10 min
COFFEE BREAK
@ Renaissance Ballroom Foyer

Take a break and get a coffee, juice, water and/or small snack to refresh for the next session.
18:00
20:00
DINNER ON OWN
@ Your Decision.

Haven't decided on a dinner location yet? Head to the Hospitality Lounge at Rocks Patio to meet up with old friends or make new ones over drinks and light appetizers before heading to dinner in Palm Springs.
18:00
22:00
HOSPITALITY LOUNGE
@ Santa Rosa and/or Rocks Terrace (if weather is agreeable)

If we're lucky we'll get to enjoy the warm, dry Palm Springs atmosphere on the patio overlooking the pool, with fire pits.
18:30
20:00

PRIVATE DISCUSSION GROUP
Private Dinner for Scientific Committee members to discuss development of the scientific program.
Chair: David Herold
@ Pueblo

Monday

6:00
7:00
YOGA
@ San Jacinto

Energize yourself for the day! Yoga is a complimentary offering for all MSACL registrants.
A limited number of yoga mats will be provided.
6:00
9:00
BREAKFAST
@ Date Restaurant

MSACL Breakfast Voucher provides comped breakfast.
Others can purchase breakfast at restaurant.
Short Course registrants receive meal vouchers during badge pick-up.
7:00
20:00
BADGE PICKUP
@ Renaissance Ballroom Foyer
8:00
12:00

SHORT COURSES: Group A
10 minute Coffee Breaks at every :50, except before lunch and last hour of class.
Lunch 12:00 - 1:00 PM at Date Restaurant.

Continued from Sunday
Clinical MS 301
A Comprehensive Review of Clinical Mass Spectrometry Technology & Techniques, including Miniaturization
Jack Henion, PhD
Level: 2-3 (Intermediate - Advanced)
Location: Mesquite D
Continued from Sunday
Data Science 101
Breaking up with Excel: A Newbie's Introduction to the R Statistical Programming Language
Daniel Holmes, MD & Stephen Master, MD, PhD
Level: 1-2 (Beginner - Intermediate)
Location: Room 2 (Catalina)
Continued from Sunday
LC-MSMS 101
Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory
Judy Stone, PhD, Lorin Bachmann, PhD & Grace van der Gugten
Level: 1-2 (Beginner - Intermediate)
Location: Room 3 (Madera)
Continued from Sunday
LC-MSMS 301
Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics
Russell Grant, PhD & Matthew Crawford
Level: 3 (Advanced)
Location: Room 4 (Pasadena)
Continued from Sunday
Proteomics 202
Practical Proteomics Using the Skyline Software Ecosystem
Mike MacCoss, PhD, Brendan MacLean, Lindsay Pino, and Sandi Spencer
Level: 1-3 (Beginner -Advanced)
Location: Chino B
8:30
12:30

SHORT COURSES: Group B
10 minute Coffee Breaks at every :20, except before lunch and last hour of class.
Lunch 12:30 - 1:30 PM at Date Restaurant.

Continued from Sunday
Data Science 201
Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling
Patrick Mathias, MD, PhD & Randall Julian, PhD
Level: 2 (Intermediate)
Location: Room 1 (Mojave Learning Center)
Continued from Sunday
MALDI 103
MALDI-MS Fundamentals and its Emerging Role in Pathology and Laboratory Medicine
Mark W. Duncan, PhD & Mari L. DeMarco, PhD
with Guest lecturers:
Zhen Zhao, Weill Cornell Medical School,
Fang Wu, University of Saskatchewan,
Dobrin Nedelkov, Isoformix Inc,
Jeff Spraggins, Vanderbilt, and
Clifton Fagerquist, USDA
Level: 1-2 (Beginner - Intermediate)
Location: Mesquite G
Continued from Sunday
Metabolomics 201
Application of High Resolution Mass Spectrometry and Metabolomics in Clinical Analysis
Timothy Garrett, PhD & Erin Baker, PhD
Level: 2 (Intermediate)
Location: Mesquite F
Continued from Sunday
Presentations 101
How to Maximize Your Influence Through Creating Compelling Presentations
Karen Mahooti, MBA
Level: 1-2 (Beginner - Intermediate)
Location: Chino A
Continued from Sunday
Proteomics 201
Clinical Proteomics
Andy Hoofnagle, MD, PhD, Cory Bystrom, PhD & Chris Shuford, PhD
Level: 2-3 (Intermediate - Advanced)
Location: Room 5 (Sierra/Ventura)
9:00
13:00

SHORT COURSES: Group C
10 minute Coffee Breaks at every :50, except before lunch and last hour of class.
Lunch 1:00 - 2:00 PM at Date Restaurant.

Continued from Sunday
LC-MSMS 201
Understanding and Optimization of LC-MS/MS to Develop Successful Methods for Identification and Quantitation in Complex Matrices
Robert D. Voyksner, PhD
Level: 2 (Intermediate)
Location: Andreas
Continued from Sunday
LC-MSMS 202
Practical LC-MS Maintenance and Troubleshooting
J. Will Thompson, PhD, Erik J. Soderblom, PhD & Chris Shuford, PhD
Level: 2 (Intermediate)
Location: Mesquite H
Continued from Sunday
MALDI 102
Practical Considerations for MALDI Imaging Mass Spectrometry
Michelle Reyzer, PhD
Level: 1-2 (Beginner - Intermediate)
Location: Snowcreek
Continued from Sunday
Sample Prep 201
Sample Preparation and Alternative Matrices for LC-MS Assays
William Clarke, PhD & Mark Marzinke, PhD
Level: Beginner / Intermediate
Location: Mesquite E
0:20 or 0:50
for 10 min
COFFEE BREAK
@ Renaissance Ballroom Foyer

Take a break and get a coffee, juice, water and/or small snack to refresh for the next session.
12:00
14:00
LUNCH
@ Date Restaurant & Patio

Short Course Registrants: You have 1 hr for lunch.
MSACL Lunch Voucher will provide you comped meal. Others can purchase lunch at the restaurant.
Short Course registrants receive lunch voucher during badge pick-up.
13:00
17:00

SHORT COURSES: Group A
10 minute Coffee Breaks at every :50, except last hour of class.

Continued from Monday AM
Clinical MS 301
A Comprehensive Review of Clinical Mass Spectrometry Technology & Techniques, including Miniaturization
Jack Henion, PhD
Level: 2-3 (Intermediate - Advanced)
Location: Mesquite D
Continued from Monday AM
Data Science 101
Breaking up with Excel: A Newbie's Introduction to the R Statistical Programming Language
Daniel Holmes, MD & Stephen Master, MD, PhD
Level: 1-2 (Beginner - Intermediate)
Location: Room 2 (Catalina)
Continued from Monday AM
LC-MSMS 101
Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory
Judy Stone, PhD, Lorin Bachmann, PhD & Grace van der Gugten
Level: 1-2 (Beginner - Intermediate)
Location: Room 3 (Madera)
Continued from Monday AM
LC-MSMS 301
Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics
Russell Grant, PhD & Matthew Crawford
Level: 3 (Advanced)
Location: Room 4 (Pasadena)
Continued from Monday AM
Proteomics 202
Practical Proteomics Using the Skyline Software Ecosystem
Mike MacCoss, PhD, Brendan MacLean, Lindsay Pino, and Sandi Spencer
Level: 1-3 (Beginner -Advanced)
Location: Chino B
13:30
17:30

SHORT COURSES: Group B
10 minute Coffee Breaks at every :20, except last hour of class.

COURSE START
Forensic Toxicology 101
Basic Forensic Toxicology
Jarrad Wagner, Ph.D., F-ABFT, Allison Veitenheimer, Ph.D., Russell Lewis, Ph.D., F-ABFT
Level: 1 (Beginner)
Location: Pueblo A
COURSE START
Lab Medicine 101
Basics of Laboratory Medicine
Prof. Dr. med. Michael Vogeser
Level: 1 (Beginner)
Location: Agua Caliente
COURSE START
Microbiology 201
Mass Spectrometric Methods of Microbial identification
John Lapek, PhD & Chris Cox, PhD
Level: 2 (Intermediate)
Location: Pueblo B
Continued from Monday AM
Data Science 201
Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling
Patrick Mathias, MD, PhD & Randall Julian, PhD
Level: 2 (Intermediate)
Location: Room 1 (Mojave Learning Center)
Continued from Monday AM
MALDI 103
MALDI-MS Fundamentals and its Emerging Role in Pathology and Laboratory Medicine
Mark W. Duncan, PhD & Mari L. DeMarco, PhD
with Guest lecturers:
Zhen Zhao, Weill Cornell Medical School,
Fang Wu, University of Saskatchewan,
Dobrin Nedelkov, Isoformix Inc,
Jeff Spraggins, Vanderbilt, and
Clifton Fagerquist, USDA
Level: 1-2 (Beginner - Intermediate)
Location: Mesquite G
Continued from Monday AM
Metabolomics 201
Application of High Resolution Mass Spectrometry and Metabolomics in Clinical Analysis
Timothy Garrett, PhD & Erin Baker, PhD
Level: 2 (Intermediate)
Location: Mesquite F
Continued from Monday AM
Presentations 101
How to Maximize Your Influence Through Creating Compelling Presentations
Karen Mahooti, MBA
Level: 1-2 (Beginner - Intermediate)
Location: Chino A
Continued from Monday AM
Proteomics 201
Clinical Proteomics
Andy Hoofnagle, MD, PhD, Cory Bystrom, PhD & Chris Shuford, PhD
Level: 2-3 (Intermediate - Advanced)
Location: Room 5 (Sierra/Ventura)
14:00
18:00

SHORT COURSES: Group C
10 minute Coffee Breaks at every :50, except last hour of class.

Continued from Monday AM
LC-MSMS 201
Understanding and Optimization of LC-MS/MS to Develop Successful Methods for Identification and Quantitation in Complex Matrices
Robert D. Voyksner, PhD
Level: 2 (Intermediate)
Location: Andreas
Continued from Monday AM
LC-MSMS 202
Practical LC-MS Maintenance and Troubleshooting
J. Will Thompson, PhD, Erik J. Soderblom, PhD & Chris Shuford, PhD
Level: 2 (Intermediate)
Location: Mesquite H
Continued from Monday AM
MALDI 102
Practical Considerations for MALDI Imaging Mass Spectrometry
Michelle Reyzer, PhD
Level: 1-2 (Beginner - Intermediate)
Location: Snowcreek
Continued from Monday AM
Sample Prep 201
Sample Preparation and Alternative Matrices for LC-MS Assays
William Clarke, PhD & Mark Marzinke, PhD
Level: Beginner / Intermediate
Location: Mesquite E
0:20 or 0:50
for 10 min
COFFEE BREAK
@ Renaissance Ballroom Foyer

Take a break and get a coffee.
18:00
20:00
DINNER ON OWN
@ Your Decision
18:00
22:00
HOSPITALITY
@ Santa Rosa and/or Rocks Terrace (if weather is agreeable)

Meet here for a quick drink before going out for dinner. Cheese and fruit come out at 20:00.

Tuesday

6:00
7:00
YOGA
@ San Jacinto

Energize yourself for the day! Yoga is a complimentary offering for all MSACL registrants.
A limited number of yoga mats will be provided.
6:00
9:00
BREAKFAST
@ Date Restaurant

MSACL Breakfast Voucher provides comped breakfast.
Others can purchase breakfast at restaurant.
Short Course registrants receive meal vouchers during badge pick-up.
7:00
20:00
BADGE PICKUP
@ Renaissance Ballroom Foyer
8:00
12:00

SHORT COURSES: Group A
10 minute Coffee Breaks at every :50, except last hour.

Continued from Monday PM
Clinical MS 301
A Comprehensive Review of Clinical Mass Spectrometry Technology & Techniques, including Miniaturization
Jack Henion, PhD
Level: 2-3 (Intermediate - Advanced)
Location: Mesquite D
Continued from Monday PM
Data Science 101
Breaking up with Excel: A Newbie's Introduction to the R Statistical Programming Language
Daniel Holmes, MD & Stephen Master, MD, PhD
Level: 1-2 (Beginner - Intermediate)
Location: Room 2 (Catalina)
Continued from Monday PM
LC-MSMS 101
Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory
Judy Stone, PhD, Lorin Bachmann, PhD & Grace van der Gugten
Level: 1-2 (Beginner - Intermediate)
Location: Room 3 (Madera)
Continued from Monday PM
LC-MSMS 301
Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics
Russell Grant, PhD & Matthew Crawford
Level: 3 (Advanced)
Location: Room 4 (Pasadena)
Continued from Monday PM
Proteomics 202
Practical Proteomics Using the Skyline Software Ecosystem
Mike MacCoss, PhD, Brendan MacLean, Lindsay Pino, and Sandi Spencer
Level: 1-3 (Beginner -Advanced)
Location: Chino B
8:30
12:30

SHORT COURSES: Group B
10 minute Coffee Breaks at every :50, except last hour.

Continued from Monday PM
Forensic Toxicology 101
Basic Forensic Toxicology
Jarrad Wagner, Ph.D., F-ABFT, Allison Veitenheimer, Ph.D., Russell Lewis, Ph.D., F-ABFT
Level: 1 (Beginner)
Location: Pueblo A
Continued from Monday PM
Lab Medicine 101
Basics of Laboratory Medicine
Prof. Dr. med. Michael Vogeser
Level: 1 (Beginner)
Location: Agua Caliente
Continued from Monday PM
Microbiology 201
Mass Spectrometric Methods of Microbial identification
John Lapek, PhD & Chris Cox, PhD
Level: 2 (Intermediate)
Location: Pueblo B
Continued from Monday PM
Data Science 201
Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling
Patrick Mathias, MD, PhD & Randall Julian, PhD
Level: 2 (Intermediate)
Location: Room 1 (Mojave Learning Center)
Continued from Monday PM
MALDI 103
MALDI-MS Fundamentals and its Emerging Role in Pathology and Laboratory Medicine
Mark W. Duncan, PhD & Mari L. DeMarco, PhD
with Guest lecturers:
Zhen Zhao, Weill Cornell Medical School,
Fang Wu, University of Saskatchewan,
Dobrin Nedelkov, Isoformix Inc,
Jeff Spraggins, Vanderbilt, and
Clifton Fagerquist, USDA
Level: 1-2 (Beginner - Intermediate)
Location: Mesquite G
Continued from Monday PM
Metabolomics 201
Application of High Resolution Mass Spectrometry and Metabolomics in Clinical Analysis
Timothy Garrett, PhD & Erin Baker, PhD
Level: 2 (Intermediate)
Location: Mesquite F
Continued from Monday PM
Presentations 101
How to Maximize Your Influence Through Creating Compelling Presentations
Karen Mahooti, MBA
Level: 1-2 (Beginner - Intermediate)
Location: Chino A
Continued from Monday PM
Proteomics 201
Clinical Proteomics
Andy Hoofnagle, MD, PhD, Cory Bystrom, PhD & Chris Shuford, PhD
Level: 2-3 (Intermediate - Advanced)
Location: Room 5 (Sierra/Ventura)
9:00
13:00

SHORT COURSES: Group C
10 minute Coffee Breaks at every :50, except last hour.

Continued from Monday PM
LC-MSMS 201
Understanding and Optimization of LC-MS/MS to Develop Successful Methods for Identification and Quantitation in Complex Matrices
Robert D. Voyksner, PhD
Level: 2 (Intermediate)
Location: Andreas
Continued from Monday PM
LC-MSMS 202
Practical LC-MS Maintenance and Troubleshooting
J. Will Thompson, PhD, Erik J. Soderblom, PhD & Chris Shuford, PhD
Level: 2 (Intermediate)
Location: Mesquite H
Continued from Monday PM
MALDI 102
Practical Considerations for MALDI Imaging Mass Spectrometry
Michelle Reyzer, PhD
Level: 1-2 (Beginner - Intermediate)
Location: Snowcreek
Continued from Monday PM
Sample Prep 201
Sample Preparation and Alternative Matrices for LC-MS Assays
William Clarke, PhD & Mark Marzinke, PhD
Level: Beginner / Intermediate
Location: Mesquite E
0:20 or 0:50
for 10 min
COFFEE BREAK
@ Renaissance Ballroom Foyer

Take a break and get a coffee, juice, water and/or small snack to refresh for the next session.
10:00
12:00

DISCUSSION GROUP
@ Room 6 (Smoketree)

FDA Overview of the Process for Clearance and Approval of Mass Spectrometry-based In vitro Diagnostic Devices
SmokeTree
Lead(s): Doug Jeffery & Matthew Humbard
11:00
16:00
PLACE POSTERS
@ Exhibit Hall

All posters for entire conference to be placed during this period.
12:00
14:00
LUNCH
@ Date Restaurant and Terrace

Comped for Short Course attendees with Voucher. Others can purchase at restaurant.
14:00
END OF SHORT COURSE PROGRAM
@ Various
14:00
14:15
WELCOME & ORIENTATION
@ California Ballroom
PLENARY 1
@ California Ballroom
Chair: TBA
14:15
15:00
Community-Scale Translation of Mass Spectrometry Big Data into Crowdsourced Proteomics and Metabolomics Resources
Nuno Bandeira
University of California, San Diego
Translating the growing volumes of proteomics mass spectrometry data into reusable evidence of the occurrence and provenance of proteomics and metabolomics events requires the development of novel community-scale computational workflows. We show how advanced distributed computing algorithms can be used to process tens of terabytes of public data to reveal hundreds of millions of new identifications, including the discovery of novel proteins and hypermodified peptides with over 100 modification variants. We further show how large scale reanalyses can be reliably aggregated into community-scale crowdsourced spectral libraries enabling high-throughput detection and discovery in newly acquired data.
15:00
15:30
COFFEE BREAK
@ Renaissance Ballroom Foyer

Coffee break with cookies and fruit.
15:30
16:15

DISCUSSION PANEL
@ California Ballroom

The Future of Clinical Mass Spectrometry
California Ballroom
Lead(s): Daniel Holmes

Panel Discussion on where we go from here with academic and industry leaders in the field including Jennifer van Eyk, Ceders-Sinai, Erin Baker, Pacific Northwest National Laboratories, Randall Julian, Indigo BioAutomation, Rob DeWitte, Thermo Scientific, Nigel Clarke, Quest Diagnostics

16:15
16:30
INTERMISSION
@ Renaissance Foyer
16:30
17:00
POSTER LIGHTNING TALKS
@ California Ballroom

90 seconds 1 slide. View up to 15 poster presentation presented.
17:00
17:30
EXHIBITOR LIGHTNING TALKS
@ California Ballroom

90 seconds and 1 slide. Get to know some vendors ... fast. Up to 15 vendor summaries to be presented.
17:30
20:00
EXHIBITS DINNER RECEPTION
@ Exhibit Hall

Drinks, beer & wine with BBQ buffet. Enjoy mingling with colleagues and Exhibitors. Take time to explore the Posters.
18:00
19:00
MEET-THE-EXPERTS: Booth Tours
@ Exhibit Hall
19:00
20:00
TROUBLESHOOTING POSTER ROUNDS
@ Exhibit Hall - Poster Board 40

Co-Chairs: Judy Stone & Grace van der Gugten
Join a troubleshooting poster discussion to learn something new or add your two cents.
19:00
Overcoming Occasional Interference in Patient Samples on a Stimulants Assay
Benjamin Beppler
TriCore Reference Laboratories
19:20
Metformin Interference in LC-MS/MS Analysis of Plasma Methoxycatecholamines
Marianne Bergmann
Lillebaelt Hospital
19:40
Fat Loving Vitamins – the Struggle is Real
Matthew Crawford
LabCorp
20:00
21:00

DISCUSSION GROUPS
@ various

CDC Standardization Programs Forum
Rm 2: Catalina
Lead(s): Julianne Botelho & Hubert Vesper

Participants will discuss how CDC Standardization Programs support laboratories with improving measurements for key hormones such as 25-hydroxyvitamin D, estradiol, and testosterone. Included will be additional discussions about new projects and tools available in CDC Standardization Programs.

Professional Societies and the FDA: Dialogue on the Future of Clinical Mass Spectrometry
Rm 4: Pasadena
Lead(s): Stephen Master

Laboratory medicine professional societies, such as the AACC and CAP, have a longstanding mission to improve the quality of clinical care through validated, reproducible testing. Mass spectrometry has emerged as the gold standard for testing in a variety of domains, such as newborn screening / inborn errors of metabolism and endocrinology. As such, there is a broad desire among the professional societies as well as regulatory agencies such as the FDA to ensure that laboratory innovation continues to advance patient care while ensuring that appropriate safeguards are in place to maintain quality. In this session, we will have a dialogue between representatives of various stakeholder organizations to discuss these shared goals, the best ways to attain them, and ways in which practitioners of mass spectrometry can themselves contribute to the most efficient advance of the field.

20:00
22:00
HOSPITALITY
@ Santa Rosa and Rocks Terrace (if weather is agreeable)

Light Appetizers and Drinks served.

Wednesday

6:00
7:00
YOGA
@ San Jacinto

Energize yourself for the day! Yoga is a complimentary offering for all MSACL registrants.
A limited number of yoga mats will be provided.
6:30
8:15
WORKSHOP BREAKFAST
@ Renaissance Ballroom Foyer

Enjoy a light continental breakfast before exploring a corporate workshop.
7:00
7:45

CORPORATE WORKSHOPS AM β

MilliporeSigma
Room 2

Waters
Room 4

Veritomyx
Room 5

7:45
8:00
INTERMISSION
@ Renaissance Ballroom Foyer
8:00
8:45

CORPORATE WORKSHOPS AM γ

Restek
Room 1

Neoteryx
Room 2

Pre-Register

Dr. Paul Jannetto
Mayo Clinic
Director, Clinical Mass Spectrometry Lab, Clinical and Forensic Toxicology Lab, and Metals Lab

Title: The Patient & Lab Perspective: Capillary vs. Venous Monitoring of Immunosuppressants

Summary of Presentation:
This session will provide a brief summary of a clinical pilot study where 100 patients were enrolled to compare the analytical results and patient satisfaction from a traditional venous whole blood draw versus a capillary collected whole blood sample using the Mitra microsampling collection device. In addition, the operational and analytical validation of the new automated Mitra workflow will be discussed.

SCIEX
Room 3

Waters
Room 4

Indigo BioAutomation
Room 5

8:45
9:00
INTERMISSION
@ Renaissance Foyer
GENERAL SCIENTIFIC Session 1
Track 1
Room 1 (Mojave Learning Center)
Cannabinoids - Keynote
Chair: David Schwope
Track 2
Room 2 (Catalina)
Informatics Keynote
Chair: Patrick Mathias
Track 3
Room 3 (Madera)
Mobilize, Derivatize and Free: Novel Approaches to Vitamin D
Chair: Joe El-Khoury
Track 4
Room 4 (Pasadena)
Therapeutic Proteins
Chair: Andy Hoofnagle
Track 5
Room 5 (Sierra)
Targeted Metabolomics Analysis
Chair: Erin Baker
Track 6
Room 6 (SmokeTree)
Tissue Imaging Keynote
Chair: Ron Heeren
Track 7
Pueblo
Practical Training : Intermediate
Chair: TBA
Track 8
Chino
Practical Training : Beginner
Chair: TBA
Track 9
Andreas
Microbiology Identification
Chair: Kent Voorhees
9:00
9:20
Mass Spectrometry Meets Medical and Legal Cannabis
Marilyn Huestis
University of Maryland School of Medicine
On the Building of the Skyline Targeted Mass Spec Software
Brendan MacLean
University of Washington
Using Ion Mobility to Reduce Chromatography Time for Liquid Chromatography-Ion Mobility-Mass Spectrometry Quantitation of 25-Hydroxyvitamin D in Human Serum
Nicholas Oranzi
University of Florida
Tumor Tissue Proteomics in the CAP/CLIA Laboratory: A 5-year Update
Maryann Vogelsang
NantOmics
Measurement of Underivatized Amino Acids in Dried Blood Spots by Isocratic LC-MS/MS to Diagnose and Monitor Multiple Metabolic Disorders
Cheryl Garganta
University of Florida
Application of N-Glycan MALDI MS Imaging to Identify Biomarker Signatures of Advanced Cancers in FFPE Tissues
Richard Drake
Medical University of South Carolina
...
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Session
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Next
Session
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Metal Oxide Laser Ionization MS Bacterial Fatty Acid Composition for Rapid ID and Antibiotic Resistance Determination
Chris Cox
Colorado School of Mines
9:20
9:40
...
Keynote
...
...
Keynote
...
LC-MS/MS Method for Measurement of Free 25-Hydroxy Vitamin D
Mark Kushnir
ARUP Institute for Clinical and Experimental Patho
Stop the Inflixi-Madness: Comparison of Immunometric and Mass Spectrometric Therapeutic Drug Monitoring Assay
Grace van der Gugten
St Paul's Hospital
Persistently Increased Alloisoleucine in a Patient without Maple Syrup Urine Disease
Joesph Wiencek
University of Virginia School of Medicine
...
Keynote
...
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Starts
Next
Session
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Starts
Next
Session
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Laser Assisted Rapid Evaporative Ionisation Mass Spectrometry (LA-REIMS): An Automated High-Throughput Platform for Clinical Microbiology and Beyond
Simon Cameron
Imperial College London
9:40
10:00
...
Keynote
...
...
Keynote
...
Optimized Derivatization Techniques for Quantitation of Vitamin D in Serum by LC-MS/MS
Carl Jenkinson
University of Birmingham
Comparison of Protein Extraction, Detection, and Quantitation Methods for Therapeutic Monoclonal Antibodies; LC-MS/MS Tryptic Peptide vs Intact LC-MS
Paula Ladwig
Mayo Clinic
Multiple Reaction Monitoring (MRM) Profiling: Metabolomics Discovery Methodology Demonstrated with a Human Plasma Coronary Artery Disease Study
Karen Yannell
Purdue University
...
Keynote
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Investigating Pseudomonas aeruginosa Using Rapid Evaporative Ionization Mass Spectrometry: Metabolic Characterization, Strain Typing and Clinical Applications
Emmanuelle Bardin
Imperial College London
10:00
11:00
EXHIBITS & POSTER SESSION
@ Exhibit Hall

Positions A & D on Odd Poster #'s to be attended.
Soft drinks & fruit served. Coffee and Tea available at participating vendor booths.
10:00
11:00
MEET-THE-EXPERTS: POSTER TOURS
@ Exhibit Hall
GENERAL SCIENTIFIC Session 2
Track 1
Room 1 (Mojave Learning Center)
Cannabinoids - Alternative Matrices
Chair: Jackie Hubbard
Track 2
Room 2 (Catalina)
Joint Informatics and Microbiology Keynote
Chair: TBA
Track 3
Room 3 (Madera)
Endocrine Keynote
Chair: Dan Holmes
Track 4
Room 4 (Pasadena)
Proteomics and Precision Medicine
Chair: Tim Collier
Track 5
Room 5 (Sierra)
Direct Analysis in Metabolomics
Chair: TBA
Track 6
Room 6 (SmokeTree)
New Applications
Chair: Stephanie Cologna
Track 7
Pueblo
Practical Training Intermediate: How to Achieve Lower Quantitation Limits
Chair: Russ Grant
Track 8
Chino
Practical Training Basic: Introduction to Quantitative LC-MSMS
Chair: Alec Saitman
Track 9
Andreas
Joint Informatics and Microbiology Keynote
Chair: TBA
11:00
11:20
Simple and Rapid LC-MS/MS Methods for Quantitation of Five Cannabinoids in Breath and Blood Samples – Correlation in the Two Sample Forms
Y. Ruben Luo
University of California, San Francisco
Can We Advance Health Monitoring the Way Google Has Advanced Text Mining for the General Population?
Pieter Dorrestein
UCSD
24,25(OH)2 Vitamin D and Vitamin D Metabolite Ratio: New Players in the Exploration of Non-Parathyroid Hypercalcemia
Etienne Cavalier
University of Liege
Proteomics Identifies DNAJB9 as a Pathogenic Protein in Fibrillary Glomerulonephritis
Surendra Dasari
Mayo Clinic
Metabolic Phenotyping of ex vivo Human Lung Perfusion
Vincen Wu
Imperial College London
Assessing the Effect of Immunization on the Global Lipidome of Mouse Spleen Using MALDI FTICR IMS
Marissa Jones
Vanderbilt University
How to Achieve Lower Quantification Limits : Part 1 : Foundations
Russ Grant
LabCorp
Clinical Mass Spectrometry Case Studies: How We Can “Read Between the Lines”
Alec Saitman
Providence Regional Laboratories
...
See
Track 2
...
11:20
11:40
Detection of in utero Exposure to Cannabis, What Are We Missing?
Triniti Scroggin
ARUP Laboratories
...
Keynote
...
...
Keynote
...
Differential Processing of High-Molecular-Weight Kininogen Throughout Normal Pregnancy
Stephenie Droll
National Institutes of Health
Innovations for Direct Tissue Analysis and Imaging with Mass Spectrometry
Richard Yost
University of Florida
Spatially Resolved Profiling of Polymyxin B Induced Acute Kidney Injury
Andreas Dannhorn
Imperial College London
How to Achieve Lower Quantification Limits : Part 2 : Formulation
Russ Grant
LabCorp
Clinical Mass Spectrometry: Benefits and Considerations
Jeff Young
Providence Health And Services
...
See
Track 2
...
11:40
12:00
Cannabinoids in Oral Fluid: Roadside Screening & Markers of Recent Use
Madeleine Swortwood
Sam Houston State University
...
Keynote
...
...
Keynote
...
MALDI-TOF MS Profiling of Biological Fluids in Precision Medicine
Mark Duncan
Biodesix Inc.
Targeted full-scan data analysis using the ChromXtractor tool suite
Adam Rosebrock
Stony Brook University
Ambient Ionization Mass Spectrometry for Molecular Characterization and Surgical Diagnosis of Endometriosis
Clara Feider
University of Texas at Austin
How to Achieve Lower Quantification Limits : Part 3 : Finesse
Russ Grant
LabCorp
A Brief Introduction to the Basics of LC-MS in the Clinical Laboratory
Nandu Chindarkar
Kaiser Permanente Regional Lab
...
See
Track 2
...
12:00
13:30
LUNCH
@ Renaissance Ballroom Foyer

Boxed lunch. • Get ready to jump into a Corporate Workshop at 12:15 after picking up lunch.
12:30
13:15

CORPORATE WORKSHOPS PM

Thermo Scientific
Room 2

Shimadzu
Room 3

Pre-Register

Implementation of a fully integrated automated sample preparation system for routine clinical LC-MS/MS analysis

Lorin Bachmann, PhD, DABCC
Associate Professor of Pathology
Co-Director of Clinical Chemistry
Virginia Commonwealth University

Lack of availability of a fully automated LC-MS/MS system has been one of the largest barriers to meaningful adoption of mass spectrometry in the routine clinical laboratory. Our laboratory evaluated the workflow attributes and analytical performance characteristics of the Clinical Laboratory Automation Module 2000 (CLAM-2000) integrated with the Prominence LCMS-8050 platform for routine analysis of total 25-OH Vitamin D (25-OHD). This configuration enabled complete integration of automated sample preparation with LCMS analysis during the validation study. The method validation included patient samples obtained from our academic medical center and was performed according to Clinical and Laboratory Standards Institute (CLSI) guidelines. The CLAM-2000 Prominence LCMS-8050 method was linear from 2ng/mL- 150 ng/mL for 25-OH D3, 3-epi 25-OH D3 and 25-OH D2. Precision was excellent with coefficients of variation < 6%. The method agreed with our validated manual LCMS method, however the CLAM-2000 Prominence LCMS-8050 system had the additional advantage of resolving the 3-epimer of 25-OH Vitamin D3. Trueness was confirmed using NIST 972a Vitamin D reference materials.

Agilent Technologies
Room 4

Pre-Register

Despite a few decades of proteomics research and the apparent discovery of multiple protein biomarkers to support the diagnosis and treatment of patients, the number of protein biomarkers that have been developed to the stage of being used routinely is disappointingly low. So, it's clear that whilst there’s huge interest in the field of research for development of new protein biomarkers and major drivers for this to happen: including the pharmaceutical industry’s need to better stratify patients for effective treatment, as yet biomarker development and delivery is proving very challenging. Why is this?

By enabling rapid assay development and evaluation, SRM/MRM on triple quadrupole mass spectrometers holds huge potential as a platform for the development of specific and sensitive 'biomarker signatures' comprising multiple proteins. However, once such prototype signatures are developed can they be clinically validated and then delivered to a clinical test environment? Addressing this current bottleneck may be dependent on the implementation of robust and reliable workflows with methods that are easy, quick and inexpensive and may be automated.

For Research Use Only. Not for use in diagnostic procedures.

Biognosys
Room 5

13:30
14:30
EXHIBITS & POSTER SESSION
@ Exhibit Hall

Positions B & C on Even Poster #'s to be attended.
Soft drinks & fruit served. Coffee and Tea available at participating vendor booths.
13:30
14:30
MEET-THE-EXPERTS: POSTER TOURS
@ Exhibit Hall
GENERAL SCIENTIFIC Session 3
Track 1
Room 1 (Mojave Learning Center)
Synthetic Cannabinoids Detection
Chair: Jack Henion
Track 2
Room 2 (Catalina)
Clinical Operations
Chair: Shannon Haymond
Track 3
Room 3 (Madera)
Clinical: Nuances in ion ratios, intensive care TDM and assessment of malabsorption.
Chair: Michael Chen
Track 4
Room 4 (Pasadena)
Applications of High Resolution Mass Spectrometry
Chair: Jenny Van Eyk
Track 5
Room 5 (Sierra)
Ion Mobility and High Resolution in Metabolomics
Chair: Adam Rosebrock
Track 6
Room 6 (SmokeTree)
Intraoperative Diagnosis
Chair: David Muddiman
Track 7
Pueblo
Practical Training Intermediate: Pharmacogenetics & MALDI-TOF
Chair: TBA
Track 8
Chino
Practical Training Basic: Purchasing Your First LC-MSMS
Chair: Deb French
Track 9
Andreas
Microbiology Keynote
Chair: Chris Cox
14:30
14:50
The Utility of LC-QTOF/MS in Proactive Synthetic Cannabinoid Testing in the Psychoactives Surveillance Consortium and Analysis Network (P SCAN)
Roy Gerona
University of California, San Francisco
A Survey of Clinical Laboratories to Determine Needs for Clinical Mass Spectrometry Data Exchange
Patrick Mathias
University of Washington
Simvastatin as a Biomarker for Intestinal Villous Health for Celiac Disease Patients
Robert Voyksner
ImmunogenX
Everything You Wanted to Know (sort of) about High Resolution Q-TOF Quantitation of Peptides But Were Afraid to Ask
Michael Lassman
Merck & Co
Lipidomic and Metabolomic Profiles Investigating the Role of Alzheimer’s Disease and Genotype
Xueyun Zheng
Pacific Northwest National Laboratory
An International “iKnife” Network to Validate Tissue-Specific Database Across Multi-Centers
Zsolt Bodai
Imperial College London
Getting Started with Pharmacogenetics Testing and Mass Spectrometry - I
Fang Wu
St. Paul's Hospital, Saskatoon Health Region
Selecting and Planning for the Right Mass Spectrometer_i
Deborah French
University of California San Francisco
Microbial Applications of Mass Spectrometry
Kent Voorhees
Colorado School of Mines
14:50
15:10
Screening for Synthetic Cannabinoids in Blood Using LC-QTRAP
Matthew McMullin
NMS Labs
Current Perspectives on Clinical Mass Spectrometry Auto-Data Review: An Innovative Solution
Alec Saitman
Providence Regional Regional Laboratories
A Sensitive Method for the Simultaneous UHPLC-MS/MS Analysis of Milrinone and Dobutamine in Blood Plasma Using NH4F as the Eluent Additive
Ruta Veigure
University of Tartu
Top-Down Quantitative Determination of Intact Proteins in Serum by Multi-Dimensional LC/QTOF Mass Spectrometry
Jack Henion
Q2 Solutions
Interest of High Resolution Mass Spectrometry in Metabolomics Studies for a Better Characterization of Primary Immunodeficiency in Humans
Anne Claire Boschat
Institut Imagine
PLACEHOLDER FOR [Advanced Development of ...]
Noah Giese
University of Texas at Austin
Getting Started with Pharmacogenetics Testing and Mass Spectrometry - II
Fang Wu
St. Paul's Hospital, Saskatoon Health Region
Making the Most of Vendor Visits and Discussions with Colleagues during Instrument Vendor Selection_II
Deborah French
University of California San Francisco
...
Keynote
...
15:10
15:30
A Sustainable LC-MS/MS Testing Platform for K2 Synthetic Cannabinoids
Jeffery Moran
University of Arkansas for Medical Sciences
TBAMatrix and Instrument Effects on Analyte Fragmentation and Ion Ratios
Geoffrey Rule
ARUP Laboratories
Quantitation of the Therapeutic Monoclonal Antibody Eculizumab Using High Resolution Accurate Mass Spectrometry
Ann Rivard
Mayo Clinic Clincal Mass Spec Dev Lab- DLMP
Isotopic Ratio Outlier Analysis (IROA) in Combination with Ion Mobility/Mass Spectrometry for Higher Quality Metabolomic Profiling
Robin Kemperman
University of Florida
Towards in situ Tissue Classification to Improve Prostate Cancer Diagnosis Using Mass Spectrometry Imaging
Elizabeth Randall
Brigham and Women's Hospital, Harvard Medical Scho
Getting Started with Pharmacogenetics Testing and Mass Spectrometry - III
Fang Wu
St. Paul's Hospital, Saskatoon Health Region
Financial Considerations for Purchasing a Mass Spectrometer_III
Joe El-Khoury
Yale University
...
Keynote
...
15:30
17:00
EXHIBITS & APPETIZERS
@ Exhibit Hall
15:45
16:45
MEET-THE-EXPERTS: OFFICE HOURS
@ Exhibit Hall

Meet with various experts and benefit from up to 15 minutes of private mentorship with each. Be sure to sign up at the Meet-the-Experts Rally Point in the Exhibit Hall.
PLENARY 2
@ California Ballroom
Chair: Andy Hoofnagle & Russell Grant
17:00
18:00
The Triple Quadrupole: Innovation, Serendipity and Persistence
Richard Yost

Distinguished Contribution Award Plenary Lecture

In this presentation I will provide a personal perspective on the conceptualization, development and demonstration of the analytical capabilities of the triple quadrupole mass spectrometer. And in that perspective, I will try to illustrate the roles of innovation, serendipity and persistence that are fundamental to scientific research. The triple quadrupole mass spectrometer has become the most common mass spectrometer in the world today, with sales of over $1 billion per year. It is today the gold standard for quantitative analysis in metabolomics, clinical analysis, drug discovery and development, environmental analysis, and a wide variety of other application areas. That invention and related research have helped propel mass spectrometry into the most commonly used analytical method in the world.
18:00
20:00
DINNER ON OWN
@ Your Decision

Haven't decided on a dinner location yet? Head to the Hospitality Lounge at Rocks Patio to meet up with old friends or make new ones over drinks and light appetizers before heading to dinner in Palm Springs.
18:00
22:00
HOSPITALITY
@ Santa Rosa and/or Rocks Terrace (if weather is agreeable)
18:15
22:00
VENDOR SUITES / OFF-SITE MEETINGS
@ various

Thursday

6:00
7:00
YOGA
@ San Jacinto

Energize yourself for the day! Yoga is a complimentary offering for all MSACL registrants.
A limited number of yoga mats will be provided.
6:30
8:15
WORKSHOP BREAKFAST
@ Renaissance Ballroom Foyer

Enjoy a light continental breakfast before exploring a corporate workshop.
7:00
7:45

CORPORATE WORKSHOPS AM β

MilliporeSigma
Room 2

7:45
8:00
INTERMISSION
@ Renaissance Foyer
8:00
8:45
PRIVATE: Scientific Committee Discussion Group
@ Santa Rosa
8:00
8:45

CORPORATE WORKSHOPS AM γ

Biotage
Room 1

Thermo Scientific
Room 2

SCIEX
Room 3

DPX Technologies
Room 4

Waters
Room 5

8:45
9:00
INTERMISSION
@ Renaissance Foyer
GENERAL SCIENTIFIC Session 4
Track 1
Room 1 (Mojave Learning Center)
Driving and MJ: Analytical Approaches and the Washington State Experience
Chair: TBA
Track 2
Room 2 (Catalina)
TBA
Chair: TBA
Track 3
Room 3 (Madera)
LC Free: Is it for me?
Chair: TBA
Track 4
Room 4 (Pasadena)
Proteomics - Keynote
Chair: Michael Lassman
Track 5
Room 5 (Sierra)
Biomarkers in Metabolomics
Chair: TBA
Track 6
Room 6 (SmokeTree)
Biomarker Discovery and Validation
Chair: Clara L. Feider
Track 7
Pueblo
Practical Training Intermediate: LC-MSMS Interference Testing
Chair: Zlatuse Clark
Track 8
Chino
Practical Training Basic: LC Theory for Troubleshooting
Chair: TBA
Track 9
Andreas
Analysis of Microbial Antibiotic Resistance
Chair: John Lapek
9:00
9:20
Method Development and Validation of LC-MS/MS Assay for Quantification of Cannabinoids in Whole Blood
Breland Smith
InSource Diagnostics
Statistical Identification and Quantitative Deconvolution of Hemoglobin Beta Chain Isotypes Unresolved by LC-MS by Isotopic Vector Angle Analysis
Luke Schneider
Target Discovery, Inc./ Veritomyx, Inc.
Can LC-MS be Replaced by Direct Coupling of SPME to MS in Clinical Applications?
German Gomez-Rios
University of Waterloo
Protein Biomarker Immunoaffinity Mass Spectrometry: Enabling Translational Pharmacology of Biologics in Pharma
Hendrik Neubert
Pfizer Inc
In vitro Volatile Compound Bacterial Profiling Using GC-MS and their Potential Role for the Diagnosis of Oesophago-Gastric Cancer
Mina Adam
Imperial College London UK
Lipid Mapping in Niemann-Pick Disease, Type C1
Stephanie Cologna
University of Illinois at Chicago
Taking Aim at Interference (Without Shooting Yourself in the Foot) : Part 1
Zlatuse Clark
ARUP Laboratories
LC Basics Part I: Demystifying Liquid Chromatography Separations and Hardware
Autumn Breaud
Johns Hopkins University
A Rapid, Functional, Mass Spectrometry-based Assay for Detecting Carbapenemase Activity and Differentiating Carbapenemase Class
Joshua Hayden
Weill Cornell Medical College
9:20
9:40
Detection and Levels of Cannabinoids in Whole Blood and Oral Fluid After Recent Marijuana Inhalation
Jacqueline Hubbard
University of California, San Diego
Using Data Independent Acquisition to Develop a Targeted Assay for the Generation of Molecular Signatures of Neurodegenerative Disease in Biological Fluids
Sandra Spencer
University of Washington
Evolution of Sponge Spray for Direct Sampling and Analysis by MS
Max Hecht
University of Tartu
...
Keynote
...
Metabolomic Profiling of a Large Cohort of Glioblastoma Stem Cell Lines Identifies Metabolites Associated with Clinical Outcome
Amy Caudy
University of Toronto
Combining MALDI MS Imaging with 2D Gel-based Proteomics to Reveal Potential Penile Carcinoma Biomarkers
Elisangela Silva
A.C.Camargo Cancer center
Taking Aim at Interference (Without Shooting Yourself in the Foot) : Part 2
Zlatuse Clark
ARUP Laboratories
LC Basics Part II: Troubleshooting and Staying Productive, or Up a Creek? Pick a Paddle
Autumn Breaud
Johns Hopkins University
Resistome Profiling in Gram Negative Bacteria to Identify Selection-Averse Antimicrobial Drug Targets
Anaamika Campeau
University of California, San Diego
9:40
10:00
The Prevalence of Marijuana in Suspected Impaired Driving Cases in Washington State
Brianna Peterson
Washington State Patrol
A Systematic Approach to Data-Independent Acquisition-MS for Plasma-based Proteomics Analyses
Shenyan Zhang
Cedars Sinai Medical Center
Multiple Point-of-Care Applications of Ambient Mass Spectrometry for the Emergency Department
Jentaie Shiea
National Sun Yat-Sen University
...
Keynote
...
Metabolomic Biomarkers for Human Plasma Quality
Casey Chamberlain
University of Florida
Mitochondrial Changes of Articular Cartilage by Oxygen
Brenda Bakker
University of Twente
Taking Aim at Interference (Without Shooting Yourself in the Foot) : Part 3
Zlatuse Clark
ARUP Laboratories
LC Basics Part III: Case Studies in Separations Sleuthing
Autumn Breaud
Johns Hopkins University
Lipid Signatures as Diagnostic Predictors of β-Lactam “Seesaw Effect” in Glycopeptide, Lipopeptide, and Lipoglycopeptide Resistance
Kelly Hines
University of Washington
9:00
10:00
EXHIBITOR FEEDBACK MEETING
@ Mesquite H
10:00
11:00
EXHIBITS & POSTER SESSION
@ Exhibit Hall

Positions B & C on Odd Poster Board #'s to be attended.
Soft drinks & fruit served. Coffee and Tea available at participating vendor booths.
10:00
11:00
MEET-THE-EXPERTS: POSTER TOURS
@ Exhibit Hall : Meet-the-Experts Rally Point
GENERAL SCIENTIFIC Session 5
Track 1
Room 1 (Mojave Learning Center)
Certifying Marijuana for Consumption
Chair: TBA
Track 2
Room 2 (Catalina)
Machine learning and Data mining
Chair: Steve Master
Track 3
Room 3 (Madera)
Neonatal Toxicology: from bench to bedside
Chair: Mark Marzinke
Track 4
Room 4 (Pasadena)
Proteome methods and insights
Chair: Mari DeMarco
Track 5
Room 5 (Sierra)
Joint Metabolomics and Microbiology - Keynote
Chair: Tim Garrett
Track 6
Room 6 (SmokeTree)
New Developments and Technologies
Chair: TBA
Track 7
Pueblo
Practical Training Intermediate: Quality Assurance - The Path to Peace of Mind
Chair: Kara Lynch
Track 8
Chino
Practical Training Basic: MSMS Survival Training
Chair: Phil Sobolesky
Track 9
Andreas
Joint Metabolomics and Microbiology Keynote
Chair: Tim Garrett
11:00
11:20
Analysis of Cannabis-Related Samples for Composition via LC-MS Employing a Compact Mass Spectrometer
Jack Henion
Advion, Inc
Data Mining Routine Results for Reference Intervals: Common Errors and Modern Techniques
Daniel Holmes
St. Paul's Hospital, Univ. of British Columbia
Analysis of 44 Drugs and their Metabolites in Umbilical Cord by LC-MS/MS
Vandana Megaraj
Cincinnati Childrens Hospital
Potential Clinical Implications for Measuring Thyroglobulin in Human Serum on a Micro-Flow LC-MS/MS System
Christopher Shuford
Laboratory Corporation of America
Early Detection of Cystic Fibrosis Acute Pulmonary Exacerbations by Exhaled Breath Condensate Metabolomics
Facundo Fernández
Georgia Institute of Technology
Metabolic Phenotyping of Fresh Frozen and Formalin-Fixed, Paraffin-Embedded Colorectal Tissue Samples Using DESI-MSI
Anna Mroz
Imperial College London
A Regulatory Review of QA Monitoring for LC-MS/MS: the Real Work Begins After Validation : Part 1
Kara Lynch
University of California San Francisco
Understanding the Importance of System Suitability Testing for Monitoring Instrument Health
Philip Sobolesky
University of California San Diego
...
See
Track 5
...
11:20
11:40
Mass Spectrometric Analysis of Medicinal Cannabis and Synthetic Cannabinoids at a State Public Health Laboratory
Kenneth Aldous
Wadsworth Center , NY State Department of Health
Data Mining at Scale – Turning the Data Gaze into the Data Result
Adam Zabell
Indigo BioAutomation
Performance of Umbilical Cord Tissue and Meconium Toxicology Testing in a Population of Subjects Diagnosed with Neonatal Abstinence Syndrome
Jennifer Colby
Vanderbilt University
Multiplexed Quantification of Proteins in Dried Blood Spots
Clark Henderson
University of Washington
...
Keynote
...
Hyperspectral Chemical Imaging to Probe Amyloid Pathology in Alzheimer’s Disease
Jörg Hanrieder
University of Gothenburg
Design a Customized and Effective Quality Assurance Program for Your Laboratory : Part 2
Kara Lynch
University of California San Francisco
Zen and the Art of LC-MS/MS Maintenance: Assuring Optimal Instrument Performance
Joshua Akin
UC San Diego Health
...
See
Track 5
...
11:40
12:00
A New Approach for Phytocannabinoids Comprehensive Metabolic Profiling: A Step Towards Understanding the Clinical Effects of Cannabis
Paula Berman
Technion - Israel Institute of Technology
High-Throughput Mass Spectrometry Coupled to Machine Learning Algorithms to Enable Accelerated Biomarker Discovery
Jacques Corbeil
Laval University
Method Performance and Clinical Workflow Outcomes Associated with Meconium and Umbilical Cord Toxicology Testing
Steven Cotten
Ohio State University Wexner Medical Center
Albumin Oxidizability: A Rigorous Yardstick of Plasma/Serum Exposure to Thawed Conditions
Chad Borges
Arizona State University
...
Keynote
...
Optimised Desorption Electrospray Ionisationmass Spectrometry Imaging (DESI-MSI) Method for the Analysis of Proteins/Peptides Directly from Tissue Sections
Emmanuelle Claude
Waters Corporation
Potential New Approaches for Quality Assurance Monitoring : Part 3
Lorin Bachmann
Virginia Commonwealth University
Choosing the Right Internal Standard for Good LC-MS/MS Method Development
Imir Metushi
Endocrine Sciences (LabCorp)
...
See
Track 5
...
12:00
13:30
LUNCH & EXHIBITS
@ Exhibit Hall

Box Lunch to be provided in the Exhibit Hall.
12:30
13:30
EXHIBITS & POSTER SESSION
@ Exhibit Hall

Positions A & D on Even Poster Board #'s to be attended.
Soft drinks & fruit served. Coffee and Tea available at participating vendor booths.
12:30
13:30
MEET-THE-EXPERTS: POSTER TOURS
@ Exhibit Hall : Meet-the-Experts Rally Point
13:30
14:00

CORPORATE WORKSHOPS PM

Thermo Scientific
Room 2

Shimadzu
Room 3

Pre-Register

"Simultaneous analysis of multiple steroid hormones by LC-MS/MS".

David Erikson, Ph.D., Director of the Endocrine Technologies Support Core at OHSU.

Measurement of steroid hormones has been traditionally performed by radioimmunoassay (RIA) or automatic immunoassay (AI). Recently, liquid chromatography-tandem mass spectrometry (LC-MS/MS) has emerged as the "gold standard" for steroid analysis in the clinical laboratory, as this method offers dramatic improvements in sensitivity, specificity, and automation of serum steroid measurements over immunoassay.

Our laboratory has focused on simultaneous, sensitive measurement of multiple steroid hormones in nonhuman primate and human samples for basic and clinical research using a Shimadzu Nexera-LCMS-8050 platform. Using this technology we are often able to quantify as low as 10 pg/ml using as little as 200 ul of serum from a single sample. The purpose of this presentation is to describe methodology for quantitation of endogenous steroid hormones in serum samples, as well as methods for quantitation of synthetic hormones used for contraception and therapeutic reasons.

We will discuss application of an analytical method for quantitating synthetic hormone levels in women for the purpose of monitoring systemic exposure to determine drug interactions, nonadherence, misreporting, and proper dosing.



14:00
14:15
INTERMISSION
@ Renaissance Foyer
GENERAL SCIENTIFIC Session 6
Track 1
Room 1 (Mojave Learning Center)
Cannabinoids - End Note
Chair: Marilyn Huestis
Track 2
Room 2 (Catalina)
Joint Informatics and Tissue Imaging
Chair: Jeff Spraggins
Track 3
Room 3 (Madera)
Global Reach: MS Public Health Applications
Chair: Xander van Wijk
Track 4
Room 4 (Pasadena)
Cardiovascular Proteomics
Chair: TBA
Track 5
Room 5 (Sierra)
Discovery Metabolomics
Chair: TBA
Track 6
Room 6 (SmokeTree)
Joint Informatics and Tissue Imaging
Chair: Jeff Spraggins
Track 7
Pueblo
Practical Training Intermediate: A Method Development Case History
Chair: Stephanie Marin
Track 8
Chino
Practical Training Basic: Staff Training for Mass Spectrometry
Chair: Shannon Haymond
Track 9
Andreas
Microbiology Metabolomics
Chair: Kelly Hines
14:15
14:35
Cannabis sativa L.: Cultivation, Chemistry, Analysis and Prospect Therapeutic Cannabis-based Pharmaceutical Products
Mahmoud ElSohly
University of Mississippi
...
See
Track
6
...
Detection of Synthetic Opioids Using High Resolution Mass Spectrometry
Kara Lynch
University of California San Francisco
Rapid, Accurate, and Cost-Effective Quantification of C-Reactive Protein in Plasma by High-Performance LC-MS/MS
Junyan Shi
University of British Columbia
Target Metabolomics Analysis Reveals Alteration in Pathways in 5p minus Patients by UPLC-MS/MS
Nilson Assuncao
UNIFESP
Linking Exploratory Tissue Analysis to Established Clinical Targets: Automated Discovery of Bio-Molecular Relationships Between Stained Microscopy and IMS
Raf Van de Plas
Delft University of Technology
Method Development Case History Part 1: Development and Validation
Stephanie Marin
Biotage
Developing a Curriculum for MS Training_i
Faye Vicente
Ann & Robert H Lurie Children's Hospital Chicago
Untargeted Metabolomics of 2400 Fecal Samples from American Gut Participants and ICU Subjects Reveals Information about Our Health, Behavior, and Microbiota
Alan Jarmusch
University of California, San Diego
14:35
14:55
...
Keynote
...
...
See
Track
6
...
High-Throughput Sample Preparation and LC-MS/MS Determination of Menthol, Nicotine and its Metabolites, Minor Tobacco Alkaloids, and Cessation Drugs in Urine
Sujeewa Piyankarage
Centers for Disease Control and Prevention (CDC)
Development and Characterization of a High-Throughput Method for the Enrichment of ApoA-I Associated High-Density Lipoproteins
Timothy Collier
Cleveland Heartlab, Inc.
Evaluation of the Lipid Profile in the Saliva of Children Affected by Zika Virus Infection
Diogo de Oliveira
University of Campinas
Identifying Predictive Markers of Breast Cancer Receptor Status and Molecular Subtypes Using DESI-MS Imaging
Kyana Garza
University of Texas at Austin
Method Development Case History Part 2: Can’t You Do this Faster and Better? Understanding and Addressing Needs of Clinicians, Technical Staff and Operations
Gwen McMillin
ARUP Laboratories
Developing a Curriculum for Training_II
Shannon Haymond
Northwestern University
Daily Dynamics of the Microbiome and Metabolome in Chronically Infected Lungs
Robert Quinn
University of California at San Diego
14:55
15:15
...
Keynote
...
...
See
Track
6
...
High-Throughput UPLC-MS/MS Analysis of 28 Urinary Metabolites of Toxic and Carcinogenic Volatile Organic Compounds
Victor De Jesus
Centers for Disease Control and Prevention
Development of a Multiplexed Mass Spectrometry-based Method for Absolute Quantitation of Serum Apolipoprotein (A), Independent of its Size Polymorphism
Lucia Renee Ruhaak
Leiden University Medical Center
High-Throughput Screening of Enzymatic Reactions Using IR-MALDESI
Mans Ekelof
North Carolina State University
IR MALDESI: from Technological Innovations to Cancer, HIV Treatment and Exposomics
David Muddiman
North Carolina State University
Method Development Case History Part 3: Re-Development and Re-Validation
Simuli Wabuyele
ARUP Institute for Clinical and Experimental Patho
Developing a Curriculum for Training_III
Shannon Haymond
Northwestern University
Integration of Non-Targeted Metabolic and Metagenomic Profiling of Feces After Chemical- and Salmonella-Induced Inflammation of Murine Intestines
Jikang Wu
The Ohio State University
15:15
15:30
INTERMISSION
@ Renaissance Foyer
GENERAL SCIENTIFIC Session 7
Track 1
Room 1 (Mojave Learning Center)
Beyond Cannabis: Detection of Natural Products & Alternative Medicines
Chair: TBA
Track 2
Room 2 (Catalina)
Keynote - Statistics in Science
Chair: Randy Julian
Track 3
Room 3 (Madera)
Benzodiazepines: basic applications and beyond
Chair: Kara Lynch
Track 4
Room 4 (Pasadena)
Biomarkers
Chair: Cory Bystrom
Track 5
Room 5 (Sierra)
TBA
Chair: TBA
Track 6
Room 6 (SmokeTree)
Tissue Imaging Keynote
Chair: Kristina Schwamborn
Track 7
Pueblo
TBA
Chair: TBA
Track 8
Chino

Chair: TBA
Track 9
Andreas
Proteomic Approaches to Bacterial Analysis
Chair: Anaamika Campeau
15:30
15:50
Pharmacokinetic Interactions Between Drugs and Hop Botanical Dietary Supplements Used by Menopausal Women
Richard van Breemen
Linus Pauling Institute
The Importance of Reproducible Research in High-Throughput Biology: Case Studies in Forensic Bioinformatics
Keith Baggerly
UT MD Anderson Cancer Center
A High-Resolution Mass Spectrometry Method for Designer Benzodiazepines
Xander van Wijk
The University of Chicago
Mass Spectrometry Analysis of Immune Checkpoint Proteins in Lung Cancer
Theresa Boyle
Moffitt Cancer Center
Track ClosedAdvanced Development of the MasSpec Pen for Cancer Diagnosis and Surgical Margin Evaluation
Livia S. Eberlin
University of Texas at Austin
Track ClosedTrack ClosedExploring the Hidden World of MRSA Pathogenesis
Jacob Wozniak
UCSD
15:50
16:10
The grapefruit effect: Identifying potential drug-food interactions in patients through mass-spectrometric urinary furanocoumarin detection
David Schwope
Aegis Sciences Corporation
TBAConfirming 23-Benzodiazepines in Urine for Pain Management Using LC-MS/MS – a Challenging Assay Development
Richard Lahr
Development Technologist, Mayo Clinic
Diagnosis of Male Infertility with Proteomic and Proteogenomic Biomarkers Measured in Seminal Plasma
Andrei Drabovich
University of Toronto
Track Closed...
Keynote
...
Track ClosedTrack ClosedDefining Systemic Bacterial Infection Through a Murine Organ Atlas of Response to Group A and B Strep Infections
John Lapek
UCSD
16:10
16:30
Method for Estimating Oxidative Stress by Quantifying Urinary 8-Isoprostane Using UPLC-MS/MS
Cory Holder
Oak Ridge Institute of Science and Education/ Centers for Disease Control and Prevention
TBAQuantitation of Seven Benzodiazepines and Metabolites in Urine by LC-MSMS
Yuzi (Emma) Zheng
Cleveland Clinic
Anemia, Altitude, and Autologous Blood Transfusions – Applications of a Novel Method to Measure Membrane Proteins in Dried Blood Spots
Holly Cox
Sports Medicine Research and Testing Laboratory
Track Closed...
Keynote
...
Track ClosedTrack ClosedTop-Down Proteomic Identification of Clinical Subtypes of Shiga Toxin from Shiga Toxin-Producing Escherichia coli Using MALDI-TOF-TOF Tandem Mass Spectrometry
Clifton Fagerquist
Agricultural Research Service, USDA
16:30
18:00
CLOSING EXHIBITS RECEPTION
@ Exhibit Hall

Wine, beer & cheese.
16:30
17:30
POSTER FINALISTS to ATTEND POSTERS
@ Exhibit Hall

Poster Finalists to attend posters for final evaluation by Poster judges.
16:45
17:45
TROUBLESHOOTING POSTER ROUNDS
@ Exhibit Hall - Poster Board 41

Co-Chairs: Judy Stone & Grace van der Gugten
Join a troubleshooting poster discussion to learn something new or add your two cents.
16:45
Evaluation of surrogate matrices for serum 25-hydroxyvitamin D calibrators by LC-MS/MS method
Bei-bei ZHAO
KingMed Diagnostics
17:05
Low extraction rate of 6-methylmercaptopurine in RBC
Soo Young Moon
Seoul National University Hospital
17:45
18:00
REMOVE POSTERS FROM EXHIBIT HALL
@ Exhibit Hall

You can store your poster between Smoketree F and Rm6 until 20:00.
18:00
EXHIBITS CLOSED
@ Exhibit Hall
17:45
18:15
PLENARY RECEPTION
@ California Ballroom Foyer

Wine, beer and other beverages.
18:15
18:30
POSTER AWARDS
@ California Ballroom
Chair: TBA
Join us in congratulating the winners of the poster contest.
PLENARY 3
@ California Ballroom
Chair: TBA
18:30
19:15
A New Approach to Genome Editing
Alexis Komor
University of California, San Diego
The CRISPR-Cas9 RNA-guided DNA endonuclease has contributed to an explosion of advances in the life sciences that have grown from the ability to edit genomes within living cells. Here I describe the development of base editing, a new approach to genome editing that enables the direct, irreversible conversion of one target DNA base into another in a programmable manner, without requiring double-stranded DNA backbone cleavage or a donor template. Base editing is one of many recent developments in the genome editing field that advances both the scope and effectiveness of genome editing.
19:15
21:00
CLOSING DINNER: MEXICAN FIESTA
@ California Ballroom, Renaissance Foyer & Patio

Enjoy a taste of southern California / Northern Mexico!
20:00
22:00
HOSPITALITY
@ Rocks Terrace (COLD/RAIN: Santa Rosa)

Relax, network and digest during the final moments of the conference.
20:30
22:00
PALM SPRINGS VILLAGEFEST
@ Downtown Palm Springs

More Info
22:00
CONFERENCE CLOSED
@ Renaissance