High Resolution GC/MS Measurement of Triclosan and Pentachlorophenol from Historic Cohorts of California Women (1960s, 1980s, 2000s)

Wed 11:30 AM - Track 3: Environmental Biomonitoring

June-Soo Park California EPA

June-Soo Park, Weihong Guo, Yunzhu Wang and Myrto Petreas. California Department of Toxic Substances Control, California Environmental Protection Agency, Berkeley, California 94710

Triclosan (TCS) and pentachlorophenol (PCP), extensively used as an antibacterial/anti-microbial agent since 1960s and as a fungicide for wood treatment since the 1930s, respectively, are of public health concern due to their endocrine disrupting properties. We selected serum samples from three time periods (1960s, 1980s and 2000s) from our Historic California Women Cohort studies that provide an excellent vehicle to study trends of legacy chemicals, as well as to identify new chemicals of concern. All study participants completed written consent forms. We optimized our analytical methods for the measurement of TCS and PCP in serum by using liquid/liquid extraction and phase separation techniques coupled with GC/HRMS. By using this optimized method, we found that levels of PCP (mean 19.4¡¾10.4 ng/mL wet wt.) in serum from the 1960s were among the highest recorded in human blood, while the highest levels of triclosan (2.6¡¾3.0 ng/mL wet wt.) were measured in contemporary serum samples, reflecting its patterns of use in different time periods in California. Therefore, given the persistence of these contaminants, and the widespread and increasing use (for TCS) in everyday consumer products, monitoring TCS and PCP is warranted to support measures to reduce exposures to humans and the environment and to protect public health, in agreement with Green Chemistry principles. Disclaimer: The ideas and opinions expressed herein are those of the authors and do not necessarily reflect the official position of the California Department of Toxic Substances Control.

Email: jpark@dtsc.ca.gov

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