How to Reduce False Positive Study Results Due to Bias |
Mon 3:30 PM - Track 2: Computational, Statistical, and Epidemiological Considerations for Mass Spectrometry in the Clinical Laboratory |
David Ransohoff University of North Carolina School of Medicine |
|
David Ransohoff, University of North Carolina School of Medicine, Chapel Hill, NC 27514 |
|
|
A major cause of problems in cancer marker research is when bias occurs -- a systematic difference in the compared groups that is not due to what you are trying to measure. For example, your goal is examine markers in blood in a comparison of cancers vs controls, but cancer bloods happen to come from older men while controls from younger women. Bias may lead to erroneously 'positive' study results. Bias is a particular problem in the observational or non-experimental research design used to study diagnostic tests. Sources of bias will be reviewed, along with 'what a biochemist ought to know' about how to address the problem. |
|
|
Email: ransohof@med.unc.edu |