50. Clinical Application of Stable and Radioactive Isotope Ratio Mass Spectrometry

Poster: Mon 6:30-7:30PM

Darren J. Hillegonds Lawrence Livermore National Laboratory

Darren J. Hillegonds, Lawrence Livermore National Laboratory Ross W. Williams, Lawrence Livermore National Laboratory David Herold, UC San Diego & VA San Diego Healthcare System Robert L. Fitzgerald, UC San Diego & VA San Diego Healthcare System

Modern analytical methods for isotope tracing now offer adequate precision and throughput to develop diagnostic and clinical management schemes for diseases that affect mineral and trace nutrient metabolism. Our research in this area has focused on utilization of 41Ca and accelerator mass spectrometry (AMS) in the context of calcium metabolism, which has been shown to be the most sensitive available measure of perturbations in bone turnover. We are currently expanding this research area into complimentary and competing analytical methods, including multicollector inductively coupled mass spectrometry for stable isotope measurements. This work performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

Email: hillegonds1@llnl.gov

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