50. Clinical Application of Stable and Radioactive Isotope Ratio Mass Spectrometry
Poster: Mon 6:30-7:30PM
Darren J. Hillegonds
Lawrence Livermore National Laboratory
Darren J. Hillegonds, Lawrence Livermore National Laboratory
Ross W. Williams, Lawrence Livermore National Laboratory
David Herold, UC San Diego & VA San Diego Healthcare System
Robert L. Fitzgerald, UC San Diego & VA San Diego Healthcare System
Modern analytical methods for isotope tracing now offer adequate precision and throughput to develop diagnostic and clinical management schemes for diseases that affect mineral and trace nutrient metabolism. Our research in this area has focused on utilization of 41Ca and accelerator mass spectrometry (AMS) in the context of calcium metabolism, which has been shown to be the most sensitive available measure of perturbations in bone turnover. We are currently expanding this research area into complimentary and competing analytical methods, including multicollector inductively coupled mass spectrometry for stable isotope measurements.

This work performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.