Mapping Protein Microheterogeneity: Applications in the Development of Biomarker for Type 2 Diabetes |
Tue 10:30 AM - Session: Proteins |
Randy Nelson |
Key to biomarker development is the need to move from initial discovery to verification of biomarkers, assays and evaluation methods through progressive challenges for disease detection using specific assays toward increasingly larger cohorts. To this end, targeted mass spectrometric immunoassays (MSIA) were used in the top-down characterization of plasma proteins from individuals in three cohorts |