| Innovative Mass Spectrometry Technology for the Identification of Cancer Immunotherapeutics |
| Mon 8:10 AM - Plenary Session |
Donald F. Hunt
University of Virginia |
| View Long Abstract |
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| Adoptive T-cell therapy (ACT) is the most effective treatment for metastatic melanoma. Tumor-infiltrating lymphocytes (TIL) are isolated from resected tumor, expanded ex vivo and then given back to the patient. Objective and complete responses for this therapy in a recent clinical trial of 25 late stage patients with metastatic melanoma were 72% and 16%, respectively. Reported here are the results of research to identify class I phosphopeptide antigens that are presented as a result of dysregulated signal transduction pathways in cancer cells. These antigens should make it possible to employ adoptive T-cell therapy for many additional human cancers. |
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| Email: dfh@virginia.edu |
