The Dried "X" Spot: A Keystone Supporting Mass Spectrometry Based Clinical Assays in Metabolic and Newborn Screening
Tue 4:00 PM - Track 3: Newborn Screening
Donald Chace
Pediatrix Analytical
View Long Abstract
The Dried Blood Spot (DBS) has been the cornerstone of newborn screening for nearly 50 years. There are numerous advantages for a collection matrix of this design which include a matrix for collecting small volumes of blood, ease of sample delivery, unique methods for sample preparation, and minimal space requirements for storage. Mass spectrometry is a suitable technique because of its analytical sensitivity and selectivity for low concentration endogenous substances. The model of DBS and the application of newborn screening can be extended to new assays and new sample types such as plasma, urine and hence the more generic term DXS.