The CDC’s Newborn Screening Quality Assurance Program operates quality assurance programs for newborn screening laboratories, ensuring the quality and accuracy of screening tests worldwide. In addition to monitoring filter paper blood collection device performance characteristics, dried-blood spot materials are prepared and distributed to over 450 laboratories worldwide. Tandem mass spectrometry is used widely for rapid screening for several inborn errors of metabolism. Monitoring filter paper performance characteristics and QC and PT services for MS/MS measurements in newborn screening demonstrate the need for surveillance to ensure harmonization and continuous improvements and sustain the high-performance of newborn screening laboratories worldwide.
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