| The Metabolomic Landscape of Chemotherapy Resistance |
| Mon 11:00 AM - Track 2: Therapeutic Metabolomics |
Anders Nordstrom
Karolinska Institute, Sweden |
| View Long Abstract |
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| Acquired or inherent cellular resistance to cytotoxic drugs is a major problem in the treatment of cancer patients. We are using a leukemic cancer cell line system and mass spectrometry based metabolomics to probe (1) how the metabolome evolves as a cancer cell line progress from being sensitive to being resistant towards cytotoxic agents and (2) identify differences in the metabolome between an isolated sub-clone of inherently resistant leukemic cancer cells and the metabolome of the entire cancer cell culture. Alterations in parts of pyrimidine-, propanoate- and CoA-metabolism was associated with emergence of resistance to a particular cytotoxic agent. |
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| Email: anders.nordstrom@ki.se |
