|Metabolomics of Bacterial Infection
|Mon 11:30 AM - Track 2: Therapeutic Metabolomics
The Scripps Research Institute
|View Long Abstract
|E. faecium is a leading source of nosocomial infection that is of growing clinical concern due to the number of isolates resistant to vancomycin, the so-called antibiotic of last resort. Here we describe a mass spectrometry-based analysis of the vancomycin binding site and its metabolism in clinical E. faecium isolates. The results show that an alarming number of E. faecium patient isolates determined to be susceptible by traditional clinical assays express a partially resistant phenotype. We explore the metabolic mechanisms mediating the development of high-level resistance in these organisms and discuss possible therapeutic targets to prevent its progression.