29. 3-Epi-25-OH-Vitamin D3 in Infants
Tue 12:24 PM - PosterSplash Track 3
Daniel Fabian
Viollier AG Spezialanalysen
View Long Abstract
The C3-epimer of 25-OH-vitamin D3 (25OHD3) has been detected in significant concentrations in serum samples of infants under the age of one year. Its downstream metabolite 3-epi-1,25-(OH)2-vitamin D3 (C-3 epimer) has been shown to have reduced calcemic effects in bone metabolism when compared to the physiologically active form 1,25-(OH)2-vitamin D3. Thus, monitoring the 25OHD status of this age group should also consider the level of the epimeric form. Here we describe a new method suitable for daily routine analysis by LC-MS/MS that can distinguish between the forms 25OHD2, 25OHD3 and its C-3 epimers.