20. Relationship Between the Concentration of Hydrocodone and its Conversion to Hydromorphone in Chronic Pain Patients using LC-MS/MS Urinary Excretion Data
Tue 4:54 PM - PosterSplash Track 2
Neveen Barakat
University of California, San Diego
View Long Abstract
LC-MS/MS is a useful tool to detect the concentration of hydrocodone and hydromorphone in urine specimens. Hydrocodone is metabolized by cytochrome P450 2D6 to form the active metabolite, hydromorphone. Understanding the conversion of hydrocodone to hydromorphone within pain patients may help establish a predictive model for physicians to better assess pain control. The purpose of this study is to determine the relationship between the concentration of hydrocodone and its conversion to hydromorphone using urinary excretion data from chronic pain patients.