23. Ultra High Resolution Mass Spectrometric Determination of the Marine Toxins, Azaspiracids, in Plasma
Mon 12:06 PM - PosterSplash Track 3
Zuzana Skrabakova
View Long Abstract
Azaspiracids (AZAs) are a class of polyether marine toxins produced by marine phytoplankton and accumulate in filter-feeding shellfish, including mussels, clams and scallops. Human intoxication is typical of gastrointestinal disturbance, diarrhea, nausea and vomiting.
Previously validated method for the determination of AZAs in shellfish using an LTQ Orbitrap mass spectrometer, operating at a mass resolution setting 100,000 FWHM in full-scan mode, with simultaneous targeted CID MS/MS and data-dependent HCD MS/MS acquisitions, has been applied for the determination of AZAs in plasma and this method will be applicable to studies of novel azaspiracids and their bioconversion.