20. Assessment of Proteomic Changes in the Rat Brain following 17 beta-estradiol Treatment of Hemorrhagic Shock
Mon 4:54 PM - PosterSplash Track 2
Kyoko Kojima
University of Alabama at Birmingham
View Long Abstract
Physical trauma is responsible for approximately 37 million emergency room visits, and is the leading cause of deaths for the age group of 1-44 in the United States. In this study, we explored the anti-inflammatory effect of E2 following a trauma-hemorrhage by closely examining the proteomic changes in the affected rat hypothalamus. A total of 2950 peptides corresponding to 785 proteins were identified in a label-free shotgun proteomic experiment. Among those, 251 proteins were increased in the E2 treatment group some of which can have a close interaction with Sp1 transcription factor that is involved in IL-10-mediated anti-inflammatory response.