| Physical trauma is responsible for approximately 37 million emergency room visits, and is the leading cause of deaths for the age group of 1-44 in the United States. In this study, we explored the anti-inflammatory effect of E2 following a trauma-hemorrhage by closely examining the proteomic changes in the affected rat hypothalamus. A total of 2950 peptides corresponding to 785 proteins were identified in a label-free shotgun proteomic experiment. Among those, 251 proteins were increased in the E2 treatment group some of which can have a close interaction with Sp1 transcription factor that is involved in IL-10-mediated anti-inflammatory response. |
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