22. Generating a Library of Human Microbiome-derived Microorganisms to Discover Novel Natural Products
Mon 4:30 PM - PosterSplash Track 3
Matthew Hamby
View Long Abstract
For every human cell there are ten microbial cells. Because of their abundance, microbes control diseases ranging from cancer, diabetes and infections. We are generating a library of microbiome derived organisms and are defining their secondary metabolic capacity to understand the metabolic exchange of these organisms, and their involvement of controlling the growth of pathogens, including Staph. aureus that according to the CDC kills more people in the US than HIV/AIDS. In this work we show how specific molecules of microbiome derived organisms, identified through MALDI based imaging mass spectrometry, suppress the proliferation of this health threat.