31. Metabolic Ratios of Excreted Pain Medications Obtained by LC-MS/MS Analysis can be used to Determine Aberrant Drug Metabolism
Poster: Mon 2:00-3:00PM
Amadeo Pesce
Millennium Laboratories
View Long Abstract
Quantitative urine drug screens obtained by LC-MS/MS are limited in their interpretation because the relationship between drug dosage and excretion can be highly variable due to pharmacogenomic and other patient differences. However, LC-MS/MS analyses for an individual patient can also measure one or more metabolites along with the parent drug, such as morphine/hydromorphone. We have established a patient database of the metabolic ratio (metabolite divided by parent drug molar concentrations) of several drug pairs, and defined the usual inter- and intrapatient expected range values. These can be used to monitor variances in an individual’s metabolism of a specific drug over time.