Prenatal environmental exposures to hazardous mixture components are associated with adverse outcomes, whose molecular mechanisms are largely unknown. The identification of biomarkers specific for adverse birth outcomes related to harmful exposures could provide opportunities for early intervention. However, birth outcomes are the result of a multitude of factors, and it is unlikely that a simple comparison of exposed and unexposed groups is sufficient.
Here we present an inter-laboratory strategy to identify high-confidence biomarkers for exposure-associated adverse health outcomes as well as an extended umbilical cord blood proteome map, which will serve as the foundation for ongoing biomarker discovery. |
|
