| We present a novel mass spectrometry method that uses a nano-electromechanical system (NEMS) as the mass detection element for a matrix assisted laser desorption ionization-mass spectrometry (MALDI-MS) system. A NEMS device is an on-chip nano-fabricated mechanical resonator whose frequency can be tracked electronically. Individual molecules adsorbing onto the NEMS surface alter the resonator mass, producing a frequency shift that is measured piezoresistively. Our system has several important advantages over current MALDI-MS systems including enhanced mass dynamic range, increased sensitivity, and suitability for sub-cellular imaging mass spectrometry. |
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