66. Tranexamic Acid Quantitation in Cardiopulmonary Bypass Patients Using Ultra Performance LC-MS/MS
Poster: Mon 6:30-7:30PM
Ross Molinaro
Emory University
View Long Abstract
Tranexamic acid (TXA) is a synthetic derivative of the amino acid lysine that possesses potent antifibrinlolytic activity. Despite the available literature describing the safety and effectiveness of TXA administration in patients undergoing cardiopulmonary bypass (CPB), some patients suffer from side effects such as seizures of unknown causes. There is a paucity of data examining the levels of TXA levels pre- and post-surgery. Using a UPLC-MS/MS to measure TXA in human plasma and cerebral spinal fluid (CSF) from CPB patients, we demonstrate that large variability exists in plasma and CSF levels between CPB patients given TXA based on weight.