60. Calcium Metabolism in Castration-Resistant Prostate Cancer Patients: Development of a Quantitative Urinary Assay for Extent of Bone Metastasis

Poster: Tue 6:30-7:30PM

Darren Hillegonds Lawrence Livermore Nat'l Lab

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Initial results from a calcium kinetic study demonstrate that urinary tracer abundance following 41Ca dosing is inversely correlated with bone metastasis extent in castration-resistant prostate cancer patients. Research subjects consumed a single 41Ca tracer dose and provided urine at regular intervals. Lower urinary 41Ca/Ca was significantly associated with increasing skeletal tumor burdens from 7 to 90 days after isotope administration. These results suggest that development of an isotopic urine test for bone metastasis extent is feasible, providing a non-invasive and quantitative compliment to nuclear imaging and organic measures of bone remodeling.

Email: hillegonds1@llnl.gov

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