| Global, unbiased analysis of endogenous metabolites from cells, tissues, or whole organisms (metabolomics) is becoming a fundamental tool for understanding biochemistry. While the genome and proteome are involved in upstream biochemical events, metabolites correlate with the most downstream biochemistry and therefore most closely represent the phenotype. The aim in our studies is to obtain a comprehensive view of the metabolome to expand our biochemical understanding of specific diseases. Toward this end, we have developed bioinformatics as well as solution- and surface/imaging-based mass spectrometry approaches to identify new pathways and “anti-metabolite” therapies. |
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