Glycan Markers for Disease Diagnosis
Wed 11:30 AM - Track 1: Biomarkers in Drug Discovery
Carlito Lebrilla
University of California, Davis
View Long Abstract
A new paradigm for cancer biomarker discovery is proposed. The detection and analysis of the glycans that decorate the underlying polypeptide in glycoproteins may provide more specific detection of cancer rather than examining the proteins themselves. We develop new tools for the analysis of oligosaccharides as biomarkers for diseases. Glycans are extracted from serum to determine whether the glycosylation has changed in cancer patients compared to control. This new glycans assay is used to discover biomarkers for the diagnosis of cancer including gastric, breast, prostate, and ovarian, as well as eye diseases such as ocular rosacea.
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