| The Impact of Chromatography and High Resolution Mass Spectrometry for Targeted and Non-Targeted Data Analysis |
| Wed 12:00 PM - Track 1: Biomarkers in Drug Discovery |
Timothy Croley
US Food and Drug Administration |
| View Long Abstract |
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| Automated LC/MS data analysis tools can increase analyst efficiency. UHPLC with high resolution mass spectrometry enables analysis for a number of chemicals simultaneously, and can allow for molecular formula calculation. The current work is focused on collection of full-scan data on a number of instruments. These data are then processed using third party software for a target list of compounds, and then subsequently reprocessed to generate a list of “non-targets”. To model this work, a mixture of poisons/toxins and adulterants are combined with over 500 pesticides. The overall impact of the collection parameters and analytical process will be discussed. |
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| Email: timothy.croley@fda.hhs.gov |
