High-Throughput Automated System for SISCAPA Sample Preparation for Clinical Proteomics
Wed 2:30 PM - Track 1: Sample Preparation and Automation
Matthew Rosenow
Translational Genomics Research Institute
View Long Abstract
Consistent protein identifications are the cornerstone for biomarker discovery, verification, and validation studies. Even slight variations in laboratory technique while carrying out steps of a protocol for sample preparation can lead to inconsistent protein identifications from sample to sample. To overcome this inconsistency, we have designed and developed a high-throughput automated system capable of preparing clinical samples for mass spectrometry analysis. This automated platform was designed specifically to process plasma samples using a SISCAPA workflow. The ultimate sample preparation throughput of almost 1,000 samples per day represents, to the best of our knowledge, an unparalleled capability unique to our Center.