Evaluating the Intestinal Health of Infants by Analysis of Excreted Oligosaccharides
Wed 3:00 PM - Track 2: Discovery Metabolomics
Maria Lorna A. De Leoz
University of California, Davis
View Long Abstract
Premature infants are at risk for necrotizing enterocolitis, a severe intestinal disease that may lead to death or long-term complications. A possible cause of this is abnormal gut flora. Prebiotics such as human milk oligosaccharides may help restore the infant’s gut flora by promoting growth of beneficial bacteria. This clinical trial aims to evaluate the health of intestine and urinary tract by studying oligosaccharides in feces and urine, respectively. Identification of HMOs remains a formidable challenge since heterogeneity in composition, linkages, and branching result in varied structures. This method uses nanoLC-Chip/TOF and MALDI FT-ICR MS to identify and quantify oligosaccharides.