High Throughput and Standardized LC-MS/MS Steroid-Quantification for Clinical Metabolomics
Wed 3:30 PM - Track 2: Discovery Metabolomics
Therese Koal
Biocrates Life Sciences, AG
View Long Abstract
Clinical metabolomics needs standardization of analytical assays to improve future inter-laboratory comparability. Steroid hormones are one of the most interesting endogenous metabolite class in clinical metabolomics today. We will present a newly developed high throughput and standardized steroid assay intending the quantitative determination of 16 steroids in human serum samples for clinical application. The analysis is based on a high performance liquid chromatography tandem mass spectrometry (LC-MS/MS) assay. Standardized determination of concentrations of these metabolites in serum may aid in improvements in the clinical environment, e.g. in vitro fertilization, diagnosis and treatment of steroid-related diseases.