Prerequisite: Hands-on experience with GC-MS and/or LC-MS systems.
Contrary to the belief of many, even ultra-high performance mass spectrometers cannot solve every clinical analysis problem; sometimes separation is the simple, effective and inexpensive, answer. Chromatographic separation is not rocket science; it is a science with a limited number of variables than can be optimized to improve separation prior to detection.
This 1-day course is designed for scientists with an interest in improving chromatographic analyses prior to detection by mass spectrometry. Discussions and exercises will focus on understanding the fundamental relationships in chromatographic peak resolution in order to explore options for improving separations. Practical considerations for varying experimental parameters will be discussed. Following the general discussion, specific considerations for both gas chromatography and liquid chromatography will be presented.
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