Technology & Data Science for Enhanced Patient Care



Job Posting

Chemistry Lab Scientist

Company:Vancouver General Hospital
Location:Vancouver, BC
Position:Chemistry Lab Scientist


Laboratory Scientist / LC-MS/MS Assay Development Specialist

Department of Pathology and Laboratory Medicine, Vancouver General Hospital

The Division of Clinical Chemistry at Vancouver General Hospital is seeking a highly motivated individual to join the team as a Laboratory Scientist in the Special Chemistry Laboratory. Our division serves a large patient population through the delivery of a host of routine and specialized clinical chemistry testing services and is also involved in education and research through affiliation with the University of British Columbia’s Faculty of Medicine.

Position Description:
Reporting to the Clinical Chemistry Division Head, the Laboratory Scientist will be responsible for the development and maintenance of small molecule assays for patient testing, on the Agilent Liquid Chromatography Tandem Mass Spectrometry Systems (LC-MS/MS) in the clinical laboratory. As an LC-MS/MS assay development specialist, the Laboratory Scientist will primarily provide knowledge of use, trouble-shooting, and maintenance of High Performance Liquid Chromatography instruments, triple-quadrupole mass spectrometers, and robotic liquid handling systems. The Laboratory Scientist will also provide expert advice and scientific support in other analytical techniques employed in the Special Chemistry clinical laboratory such as fluorescence spectrophotometry, etc.

Main Responsibilities:
1. Assay development and validation
• Provides expert advice and consultation and is directly involved in all LC-MS/MS assay development projects.
• Sources and chooses appropriate reagents for assay development, prepares reagents, sets up parameters for LC and mass spectrometry.
• Designs, directs, performs, analyses and interprets a wide range of experiments independently.
• Performs experimental method validation.
• Creates LC-MS/MS related Standard Operating Procedures (SOPs).
• Supports, trains, and provides technical advice and direction to LC-MS/MS users, including Medical Laboratory Technologists (MLTs), Medical Residents, Clinical Chemists and all other new and existing personnel using the equipment in newly validated methods.
• Stays apprised of new technologies in LC-MS/MS sample preparation and analysis; for example: new chromatographic techniques, new automation tools, new MS approaches.
2. Existing LC-MS/MS methods
• Provides expert advice and consultation and is directly involved in all modifications to existing assays, including data interpretation, troubleshooting and optimization of sample preparation and experimental design, and quality management for procedures and assays.
• Suggests and develops improvements to existing LC-MS/MS methods, particularly around improving sensitivity and introducing automation to increase sample throughput. Experimentally validates these streamlining projects.
• Provides expertise in solving problems that occur during routine operation of the LC-MS/MS – including tasks such as disassembly, cleaning and replacement of valves, tubing, and sample-loops.
• Schedules service calls and preventative maintenance by Agilent field service engineer(s) to minimize LC-MS/MS downtime.
• Liaises with the Biochemists to help produce reports that are convenient for clinical interpretation and provides the data in a manner that can be processed by existing in-house middleware solutions.
3. Hamilton StarLET Robotic Liquid Handler
• Programs and troubleshoots the Hamilton StarLET Robotic Liquid Handler and trains MLTs and other users on the operation of new Hamilton methods. Liaises with Hamilton software and hardware engineers to solve issues and/or arrange service calls.
• Supervises and trains users in the correct use of the Hamilton StarLET and LC-MS/MS equipment. Recommends and oversees modifications to equipment as needed.
• A level of education, training, and experience equivalent to a Masters degree or higher, in a relevant discipline.
• Minimum 5 years of experience with LC-MS/MS, preferably with Agilent instruments and software. The number of years of experience may include graduate studies, if substantial experience with LC-MS/MS has been gained as part of the academic program.
• Ability to work independently and communicate effectively with all groups of professional and technical staff, faculty and trainees through both oral and written communication.
• Strong ability to manage and monitor operations to effectively resolve problems, challenges or issues.
• Ability to exercise tact, diplomacy and discretion and demonstrate a strong sense of responsibility.
Preference will be given to candidates who have prior work experience in a hospital clinical laboratory, experience with Agilent 6460 and Ultivo systems and/or experience with Gas Chromatography Mass Spectrometry (GC-MS).
Vancouver General Hospital hires on the basis of merit and is committed to employment equity. We encourage all qualified persons to apply; however, Canadians and permanent residents of Canada will be given priority.

Interested candidates are invited to submit a letter of interest, their curriculum vitae, and three letters of reference to:
Dr. David Schaeffer
Head and Medical Director, Department of Pathology and Laboratory Medicine, Vancouver General Hospital
910 West 10th Avenue, Vancouver, BC V5Z 1M9
[email protected]

For additional information, please contact:
Dr. Catherine Cheng
Interim Head, Division of Clinical Chemistry, Vancouver General Hospital (604) 875-4111 ext. 61359 [email protected]
Application deadline: Until position filled.