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MSACL 2018 EU: Congress ProgramSalzburg, Austria • September 9 - 13, 2018
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Sunday |
1900 | Badge Pickup @ Entrance Foyer |
1400 | Lunch on Own @ Your Choice Some nearby (within one block) recommendations include: 1. The Heart of Joy (Vegetarian and Vegan) 2. my Indigo Kongresshaus (Asian Fusion) 3. Cafe Fingerlos (Cafe with the best breakfast in town) 4. IMLAUER Sky (Rooftop patio with a view) 5. Cafe Wernbacher (Austrian, great interior for a rainy day with much of the original 1950s decor, open 9am-midnight daily with Sunday Brunch buffet until 2pm)
A little further afield: |
1800 | Short Course |
 COURSE STARTData Science 101 Breaking up with Excel: An Introduction to the R Statistical Programming Language Daniel Holmes, MD & William Slade, PhD Level: Beginner - Intermediate @ Mozart 5 | COURSE START Data Science 201 Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling Patrick Mathias, MD, PhD & Randall Julian, PhD Level: Intermediate @ Mozart 4 | COURSE START LC-MSMS 101 Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory Judy Stone, PhD & Grace van der Gugten Level: Beginner @ Mozart 2 | COURSE START LC-MSMS 202 Practical LC-MS Maintenance and Troubleshooting J. Will Thompson, PhD & Erik J. Soderblom, PhD Level: Intermediate @ Paracelsus Hall | COURSE START LC-MSMS 301 Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics Russell Grant, PhD & Brian Rappold Level: Advanced @ Papageno Hall | |
| COURSE START Metabolomics 202 Metabolomics: Approaches, Applications and Challenges Julijana Ivanisevic, PhD & Elizabeth Want, PhD Level: Beginner to Intermediate @ Doppler Hall | COURSE START Proteomics 201 Clinical Proteomics Cory Bystrom, PhD & Chris Shuford, PhD Level: Intermediate - Advanced @ Trakl Hall |
for 10 min | Coffee Break @ Entrance Foyer |
1830 | Petite Reception @ Entrance Foyer A quick touch of wine and cheese before exploring the city for dinner. |
| Dinner on Own @ Your Choice Dinner Suggestions: 1. Gablerbrau (Historic ambiance with traditional food) 2. Augustiner Braustubl (Historic Abby turned beer garden with food stalls) 3. Antichi Sapori (Tasty Italian food and pizza in casual family run style, open 11:30-2:00pm and 5:30-9:00pm, closed Wed and Thurs) 4. Cafe Wernbacher (Austrian, great interior for a rainy day with much of the original 1950s decor, open 9am-midnight daily)
After dinner: |
2100 | SciCom Discussion Group @ 1st Floor Cafe Private Meeting for Scientific Committee members; includes dinner |
Monday |
900 | Welcome Coffee @ Entrance Foyer Enjoy coffee, a pastry and a chat with colleagues before the day starts. |
1300 | Short Course |
| Continued from Sunday Data Science 101 Breaking up with Excel: An Introduction to the R Statistical Programming Language Daniel Holmes, MD & William Slade, PhD Level: Beginner - Intermediate @ Mozart 5 | Continued from Sunday Data Science 201 Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling Patrick Mathias, MD, PhD & Randall Julian, PhD Level: Intermediate @ Mozart 4 | Continued from Sunday LC-MSMS 101 Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory Judy Stone, PhD & Grace van der Gugten Level: Beginner @ Mozart 2 | Continued from Sunday LC-MSMS 202 Practical LC-MS Maintenance and Troubleshooting J. Will Thompson, PhD & Erik J. Soderblom, PhD Level: Intermediate @ Paracelsus Hall | Continued from Sunday LC-MSMS 301 Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics Russell Grant, PhD & Brian Rappold Level: Advanced @ Papageno Hall | |
| Continued from Sunday Metabolomics 202 Metabolomics: Approaches, Applications and Challenges Julijana Ivanisevic, PhD & Elizabeth Want, PhD Level: Beginner to Intermediate @ Doppler Hall | Continued from Sunday Proteomics 201 Clinical Proteomics Cory Bystrom, PhD & Chris Shuford, PhD Level: Intermediate - Advanced @ Trakl Hall |
1400 | Lunch @ Entrance Foyer Lunch provided for short course attendees. |
1800 | Short Course |
| COURSE START Lab Medicine 101 Basics of Laboratory Medicine Prof. Dr. med. Michael Vogeser Level: Beginner @ Mozart 3 | COURSE START Proteomic Microbiology 201 Bottom-Up and Top-Down Proteomic Approaches for Bacterial Identification and Characterization, a Focus on MALDI-TOF and Advanced Technologies Jean Armengaud, PhD, Stefan Zimmermann, MD Level: Beginner - Intermediate @ Trapp Zimmer | Continued from Monday AM Data Science 101 Breaking up with Excel: An Introduction to the R Statistical Programming Language Daniel Holmes, MD & William Slade, PhD Level: Beginner - Intermediate @ Mozart 5 | Continued from Monday AM Data Science 201 Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling Patrick Mathias, MD, PhD & Randall Julian, PhD Level: Intermediate @ Mozart 4 | Continued from Monday AM LC-MSMS 101 Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory Judy Stone, PhD & Grace van der Gugten Level: Beginner @ Mozart 2 | |
| Continued from Monday AM LC-MSMS 202 Practical LC-MS Maintenance and Troubleshooting J. Will Thompson, PhD & Erik J. Soderblom, PhD Level: Intermediate @ Paracelsus Hall | Continued from Monday AM LC-MSMS 301 Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics Russell Grant, PhD & Brian Rappold Level: Advanced @ Papageno Hall | Continued from Monday AM Metabolomics 202 Metabolomics: Approaches, Applications and Challenges Julijana Ivanisevic, PhD & Elizabeth Want, PhD Level: Beginner to Intermediate @ Doppler Hall | Continued from Monday AM Proteomics 201 Clinical Proteomics Cory Bystrom, PhD & Chris Shuford, PhD Level: Intermediate - Advanced @ Trakl Hall |
1830 | Petite Reception @ Entrance Foyer A quick touch of wine and cheese before exploring the city for dinner. |
| Dinner on Own @ Your Choice Dinner suggestions: 1. Zum fidelen Affen (best patio dinner on a nice evening, closed Sunday) 2. Die Wiesse (Brewery Pub with beer garden open till 2am Mon-Sat) 3. Gablerbrau (Historic ambiance with traditional food) 4. Augustiner Braustubl (Historic Abby turned beer garden with food stalls) 5. Antichi Sapori (Tasty Italian food and pizza in casual family run style, open 5:30-9:00pm, closed Wed and Thurs) 6. Cafe Wernbacher (Austrian, great interior for a rainy day with much of the original 1950s decor, open 9am-midnight daily)
After dinner: |
Tuesday |
1600 | Place Posters @ 1st Floor Exhibit Hall ALL posters should be placed by 16:00. |
900 | Welcome Coffee @ Entrance Foyer Enjoy coffee, a pastry and a chat with colleagues before the day starts. |
1230 | Short Course |
| Continued from Monday PM Lab Medicine 101 Basics of Laboratory Medicine Prof. Dr. med. Michael Vogeser Level: Beginner @ Mozart 3 | Continued from Monday PM Proteomic Microbiology 201 Bottom-Up and Top-Down Proteomic Approaches for Bacterial Identification and Characterization, a Focus on MALDI-TOF and Advanced Technologies Jean Armengaud, PhD, Stefan Zimmermann, MD Level: Beginner - Intermediate @ Trapp Zimmer | Continued from Monday PM Data Science 101 Breaking up with Excel: An Introduction to the R Statistical Programming Language Daniel Holmes, MD & William Slade, PhD Level: Beginner - Intermediate @ Mozart 5 | Continued from Monday PM Data Science 201 Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling Patrick Mathias, MD, PhD & Randall Julian, PhD Level: Intermediate @ Mozart 4 | Continued from Monday PM LC-MSMS 101 Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory Judy Stone, PhD & Grace van der Gugten Level: Beginner @ Mozart 2 | |
| Continued from Monday PM LC-MSMS 202 Practical LC-MS Maintenance and Troubleshooting J. Will Thompson, PhD & Erik J. Soderblom, PhD Level: Intermediate @ Paracelsus Hall | Continued from Monday PM LC-MSMS 301 Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics Russell Grant, PhD & Brian Rappold Level: Advanced @ Papageno Hall | Continued from Monday PM Metabolomics 202 Metabolomics: Approaches, Applications and Challenges Julijana Ivanisevic, PhD & Elizabeth Want, PhD Level: Beginner to Intermediate @ Doppler Hall | Continued from Monday PM Proteomics 201 Clinical Proteomics Cory Bystrom, PhD & Chris Shuford, PhD Level: Intermediate - Advanced @ Trakl Hall |
| CONGRESS OPEN @ Europa Hall |
1400 | Opening Lunch @ Europa Hall |
1345 | Welcome, Introduction & Orientation @ Europa Hall |
1400 | CMS Journal Overview @ Europa Hall An overview on the current state of the journal, how to subscribe, the path to an Impact Factor, citations, scope, desired article format, webinars. |
| 1400 |
Opening Plenary Lecture
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1445 |
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Metabolomics Messages on Human Health and Disease Jurek Adamski Helmholtz Zentrum München
The human metabolome represents functional read out of processes in health and disease. The metabolome is both stable and highly dynamic. Stable components are determined by genetics, genomic imprinting or physiological homeostasis. The dynamics originates from circadian rhythm, hormonal status, nutrition, environmental exposure, ageing, medication or disease. Despite its interlaced origin metabolome specifically reflects distinct processes. Metabolomics studies request therefore a special study design. Unique metabolomics signatures have been identified pre-disease (like type 2 diabetes), in disease progression (chronic kidney disease) or in companion diagnostics (drug action monitoring). Metabolomics informed diagnostics has great potential for selectivity, specificity and multiplexing of indications to be screened for. |
1500 | Coffee Break @ Europa Foyer |
1600 | State of the Science Address |
| Presented by MSACL EU Scientific Committee Topic Leads, this address will provide an overview of the applications and technologies currently being used in Clinical Labs, and a clear view of the development pipeline. It will highlight applications expected to be available in the near-future, as well as emerging applications, and key contributors. Relevant talks, posters, and people present at the congress will be identified, enabling you to optimize your learning path and more effectively target potential network connections. Whether you are new to Clinical Mass Spectrometry, or a seasoned veteran, the State of the Science address should be on your agenda.
Brian Keevil (Endocrinology) |
1630 | Coffee Break @ Europa Foyer |
1700 | Poster Lightning Talks @ Europa Hall 15-20 poster presenters will be selected to present their pitch from the plenary podium within 90 seconds and with 1 slide (PDF format). |
1730 | Exhibitor Lightning Talks @ Europa Hall 15-20 exhibitors will be selected to present their pitch from the plenary podium within 90 seconds and with 1 slide (PDF format). |
| EXHIBITS OPEN @ 1st Floor Exhibit Hall |
2000 | Exhibitor Reception @ 1st Floor Exhibit Hall Buffet dinner served. |
1900 | MEET-THE-EXPERTS : Booth Tours @ 1st Floor Exhibit Hall Join an expert as they tour the booths and learn more about technologies available, what experts are looking for during the exchange, and how they interact with the booth vendors. Increase your network and your knowledge of products and services available. |
2000 | Troubleshooting Poster Rounds : Part I @ 1st Floor Exhibit Hall
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| 19:00 at poster #25a What Happened to My Topiramate? Magdalena Rajska SPADIA Lab, a.s. | 19:15 at poster #25b Optimizing Chromatographic Conditions for HILIC Analysis of Catecholamines Gareth Hammond Waters Corporation | 19:30 at poster #25c An Alternative Solution to High Blank Problems Anne Schmedes Department of Clinical Biochemistry |
2200 | Discussion Group |
| Strengths, Weaknesses, Opportunities and Threats (SWOT) : The Road to Comprehensive MS Implementation in the Clinic @ Mozart 4-5 (Track 2) Chair(s): Daniel Holmes Panelists: The process of bringing mass spectrometry from esoteric research niche to high throughput clinical analyzer is more complex and nuanced than it initially appeared. Superior analytical technology is not all that is necessary to successfully cross the chasm from early adopters to early majority. A recent editorial by Zhang and Vogeser, in Clinical Mass Spectrometry, provides an overview of the current landscape by highlighting the strengths, weaknesses, opportunities and threats that support and temper the path towards wide-spread implementation. |
| Enjoy the City @ Your Choice or get a good night's sleep |
Wednesday |
900 | Welcome Coffee @ Entrance Foyer Enjoy coffee, a pastry and a chat with colleagues before the day starts. |
845 | Corporate Workshop(s) |
900 | Intermission @ Entrance Foyer |
Scientific Session 1 |
1100 | Poster Session 1 @ 1st Floor Exhibit Hall Selected posters to be attended for 1 hour. Refer to program for posters attended during this period. |
1100 | MEET-THE-EXPERTS : Poster Tours @ 1st Floor Exhibit Hall |
Scientific Session 2 |
| Mozart 1-3 Metabolomics Methodology | Mozart 4-5 All About Breath Analysis | Papageno Endocrine Keynote | Paracelsus Glycomics 1 | Trakl MS/MS for Proteotyping Pathogens | Doppler Practical Training : Calibrators and Internal Standards for Protein MS | ||
1120 |
New Insights in CE-MS-based Metabolomics Nicolas Drouin University of Geneva |
Mass Spectrometry Applied to Large-Scale Multi-Centre Clinical Project in Breath Research Ilaria Belluomo Imperial College London  |
Mass Spectrometry Harmonisation: Paediatric Steroid TalesRonda Greaves Murdoch Children's Research Institute |
Global Glycoproteomic Analysis of O-glycosylation in Human HerpesvirusesIeva Bagdonaite University of Copenhagen |
Phylopeptidomics: A Step Closer to Adopting the Microbiome Data into Clinical Practice Lucia Grenga CEA |
Calibrators and Internal Standards in Protein Mass Spectrometry Assays: Differences, Commonalities, and Best-Practice Christopher Shuford Laboratory Corporation of America
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1140 |
Combined Targeted and Untargeted Strategy for Quantification of Amino Acids and Acylcarnitines in Clinically Relevant Biofluids and Tissue Lysates Vera van der Velpen Metabolomics Unit, University of Lausanne |
Cross Platform Validation of Mass Spectrometry for the Diagnosis of Colorectal Cancer Using a Breath Test Georgia Woodfield Imperial College London | ... Keynote ... |
In Depth O-Glycosylation Structural Analysis of Colorectal Cancer Cell Lines Katarina Madunic Leiden University Medical Center |
Characterization of the Virulome of Staphylococcus Aureus by a Highly Multiplex Approach with Scout-MRM Mouton Nicolas University de Lyon Claude Bernard | ... Extended Session ... | |
1200 |
Development of a Pipeline for Automated Reconstruction and Annotation of Data Independent Acquisition LC-MS Datasets Gonçalo Graça Imperial College London |
A Pilot Study Profiling Volatile Organic Compounds (VOCs) in the Breath of Patients with CRC Using Proton Transfer Mass Spectrometry Harrypal Panesar Imperial College London | ... Keynote ... |
HT UPLC Profiling of Total Plasma N-Glycans in Type II Diabetes Mellitus from Patients and Healthy Individuals in a Ghanaian Population Elham Memarian Leiden University medical centre |
Deciphering MALDI-TOF Identification of Bacteria Using a Proteogenomic Approach Frédéric Jauffrit Université de Lyon | ... Extended Session ... |
1330 | Lunch @ 1st Floor Exhibit Hall Lunch to be provided in the Exhibit Hall. Get ready to join a Corporate Workshop after lunch. |
1330 | Troubleshooting Poster Rounds : Part II @ 1st Floor Exhibit Hall
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| 12:30 at poster #26a Metformin Interference in LC-MS/MS Analysis of Plasma Methoxycatecholamines Marianne Bergmann Lillebaelt Hospital, Vejle | 12:45 at poster #26b Charge Wars of Ion Suppression - Awakening the Force for the Analysis of Estrogens in Clinical Research Robert Wardle Waters Corporation | 13:00 at poster #26c Cortisol Everywhere! Neus Fabregat-Cabello University of Liège, CHU de Liège | 13:15 at poster #26d Deuterium or 13C-labeled internal standards for quantification of methylmalonic acid in serum? Morten Trelle Department of Clinical Biochemistry, OUH Svendborg |
1415 | Corporate Workshop(s) |
| Shimadzu @ Mozart 1-3 (Track 1) Better Ways of Working in Routine Clinical Pathology Laboratories | Thermo Scientific @ Mozart 4-5 (Track 2) Fully Automated LC-MS – Theory becomes Reality | Agilent Technologies @ Paracelsus (Track 4) Developing and Delivering Advanced Protein Biomarker Tests for an Era of Precision Medicine | Waters @ Trakl (Track 5) Determination of Steroid Hormones in biological matrices by Tandem Mass Spectrometry |
1430 | Intermission @ Entrance Foyer |
Scientific Session 3 |
| Mozart 1-3 Metabolic Markers | Mozart 4-5 Small Molecule Keynote | Papageno Cardiovascular and Thrombotic Disease | Paracelsus Tissue Imaging Keynote | Trakl Glycomics 2 | Doppler Practical Training : EU Regulations | ||
1450 |
Discovery of Novel Galabiosylceramide-Related Biomarkers of Fabry Disease by Semi-Targeted Metabolomics: the Complex Issue of Structural Isomer InterferencesMichel Boutin Université de Sherbrooke |
Tackling Analytical Challenges in Sports Drug Testing by Mass Spectrometric Approaches Mario Thevis German Sport University, Cologne, Germany European Monitoring Center for Emerging Doping Agents (EuMoCEDA), Cologne/Bonn, Germany |
Building Standards for Proteomics: A Targeted Mass Spectrometry Approach for Quantification of Cardiovascular Disease Biomarker in Human Blood Albert Sickmann ISAS |
Combining Mass Spectrometry Imaging & Microproteomics to Investigate Intratumor Heterogeneity Liam McDonnell Fondazione Pisana per la Scienza ONLUS, Pisa, Italy |
In-Depth Characterisation of Heavily Glycosylated Proteins and Their Potential as Colorectal Cancer Biomarkers Valeriia Kuzyk Vrije Universiteit Amsterdam |
EU LC-MS Verification Brian Keevil Manchester University | |
1510 |
Identifying the Metabolic “Achilles Heel” of Adult and Childhood Brain Cancers Using LC-MS-based Metabolite Profiling Dong-Hyun Kim University of Nottingham | ... Keynote ... |
Validation of ApolipoProtein A-I Associated Lipoprotein Panel for the Prediction of Cholesterol Efflux Capacity Cory Bystrom Cleveland HeartLab | ... Keynote ... |
Development of MS-based Prostate-Specific Antigen Test with In-Depth Glycosylation Analysis Guinevere S.M. Lageveen-Kammeijer Center for Proteomics and Metabolomics, LUMC
| ... Extended Session ... | |
1530 |
Urinary Biomarkers of Dietary Intake - Quantification of Sugars for Epidemiology Studies Using LC-MS/MS Nicola Gray University of Reading | ... Keynote ... |
Defining the Measurands for Antithrombin and its Proteoforms Using Mass Spectrometry Based Techniques Renee Ruhaak Leiden University Medical Center | ... Keynote ... |
Characterisation of Prostate-Specific Antigen Isolated from Patients’ Urine Alan Moran Leiden University Medical Centre
| ... Extended Session ... |
1630 | Poster Session 2 @ 1st Floor Exhibit Hall |
1630 | MEET-THE-EXPERTS : Poster Tours @ 1st Floor Exhibit Hall |
| 1630 |
Distinguished Contribution Award Lecture
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1730 |
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Mass Spectrometry and the Elucidation of Steroid Metabolome Cedric Shackleton UCSF Benioff Children’s Hospital Oakland Research Institute, Oakland, California, and Institute of Metabolism and Systems Research (IMSR), College of Medical and Dental Sciences, University of Birmingham, UK
Sterols and steroids were among the first biomolecule groups to be studied by mass-spectrometry. The early success of GC separation in 1960 by Sweeley and Horning and the combination of GC and MS by Ragner Ryhage in Stockholm with invention of a technique for separating the bulk of carrier gas from analytes prior to ionization were fundamental. This led in the mid-60s to the first commercial dedicated GC/MS instrument, the LKB 9000. Professor Jan Sjövall (a colleague of Dr Ryhage) in particular spearheaded studies of sterols and steroids leading to multiple publications of mass spectra, and steroid quantification of serum, urinary and biliary steroids. Developments in derivatization, capillary columns and computerization were all important constituents of these developments. This presenter (a student of Sjövall) was early involved in the clinical diagnostic use of GC/MS in the 1970s and has been involved in studying urinary steroids and defining new disorders through metabolic profiles ever since. Particle beam MS (eg. FAB) was introduced in the 80s and allowed for the first time analysis of underivatised steroids and steroid conjugates. Steroid LC/MS (Thermospray) arrived in 1987 but it was a decade later before ESI and LC/MS/MS made the use of MS in the routine steroid analytical lab a practicality. Now the technique has essentially replaced RIA in routine endocrinological applications. GC/MS is labour-intensive and was never really suited to individual serum hormone analysis but has always been powerful for profiling urinary steroid metabolites, which now forms a branch of the recently-termed metabolome discipline. Recently there has been a re-birth in urinary steroid analysis in diagnosis and several groups are working on transferring GC/MS methodologies to LC/MS/MS to avoid need of derivatization and shorten chromatography times. This is a challenge because many of the “metabolite-type” steroids have weak ESI ionization and poor CID sensitivity. Two steroid groups are particularly suited to LC/MS/MS and those are the steroid sulfates and glucuronides since they have an existing ionic center. Analysis of intact conjugates avoids the labour-intensive enzyme hydrolysis, and we a pursuing their analysis. A drawback here is the paucity of authentic reference materials. A huge challenge in steroid metabolomics is the presentation of diagnostic data in a form friendly to researchers and clinicians. Many recent publications have addressed this issue, including use of heat-maps and machine learning for metabolome diagnostic interpretation. |
1930 | Exhibitor Reception @ 1st Floor Exhibit Hall Buffet dinner, appetizers and drinks to be provided. Enjoy mingling with colleagues and Exhibitors. Take time to browse the posters. |
1930 | MEET-THE-EXPERTS : Office Hours Forum @ 1st Floor Cafe Have a question from the congress that you have been itching to ask? Or a problem from work that you want to get feedback on? Or feedback on the congress? Sign up at the registration desk for 15-min blocks to share time and ideas with domain experts in a relaxed setting. |
2030 | Discussion Group |
| Development of LC-MS Certification Programs @ Mozart 4-5 (Track 2) Chair(s): Judy Stone Panelists: One major barrier to implementation of mass spectrometry (MS) in diagnostic laboratories is the lack of staff trained for use of the technique in a production setting. A variety of training options exist, but for most laboratories the assumption is that staff will have to be trained onsite. We queried the MSACL community about clinical MS training options and present a summary of the responses here. This discussion session will explore the question of certification (why, who, how) as an aid (or perhaps a barrier) to increasing the availability and recognition of competency for users of clinical mass spectrometry. | Design of Experiments – get it right from the beginning @ Papageno Hall (Track 3) Chair(s): Margrét and Unnur Thorsteinsdóttir We will demonstrate how method development can become much more efficient by utilizing design of experiments (DoE). DoE offers a practical approach for performing experiments in accordance to predefined plan, modelling by empirical functions, and graphical visualization. Example from optimization of a UPLC-MS/MS method for clinical application will be used to show the cost-effective benefit of DoE, where it allows the effect of variables to be assessed with only a fraction of the experiments that would be required by changing one-separate-factor-at-time (COST) approach and spots critical setting early on. |
| Enjoy the City @ Your Choice |
Thursday |
900 | Welcome Coffee @ Entrance Foyer Enjoy coffee, a pastry and a chat with colleagues before the day starts. |
845 | Corporate Workshop(s) |
| Zivak Technologies @ Paracelsus (Track 4) From Primary Sample Tubes to Results: World’s First Fully Automated Sample Preparation and Injection UHPLC System |
900 | SciCom Discussion Group @ 1st Floor Cafe |
900 | Intermission @ Entrance Foyer |
1000 | Exhibitor Feedback @ 1st Floor Cafe An opportunity for exhibiting vendors to provide feedback on what worked and what could use improvement. |
Scientific Session 4 |
| Mozart 1-3 Metabolomics – Clinical Studies I | Mozart 4-5 Quality Issues | Papageno Clinical Chemistry I | Paracelsus MSI for Clinical Applications | Trakl Microbiology Keynote | Doppler Practical Training : Finding Your Analyte | |||
920 |
Metabolomic Analysis of Changes in the Serum of Diabetic Patients Caused by Ulcers Arsenty Melnikov Internatrional Tomography Center SB RAS |
Quality Assurance and Quality Control in LC-MS-based Targeted Lipidomics of Human Blood Plasma Bo Burla National University of Singapore |
A Newly Developed LC-MS/MS Method for the Quantitation of Glucagon in Plasma Shows the Lack of Specificity of Former RIA Methods Jordi Farre-Segura University of Liège, CHU de Liège |
Next Generation Sequencing After MALDI MSI – A Feasibility Study Kristina Schwamborn Institute of Pathology, TU Munich |
Tandem MS-Proteotyping: Proteomics- and Genomics-based Characterization and Typing of Infectious Bacteria Edward Moore University of Gothenburg |
Where Did My Analyte Go? – coping with poor solubility and non-specific binding Catarina Horro Pita LGC, Drug Development Solutions
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940 |
A Metabolite Level View of the Gut-Brain Axis in Dementia and Aging: Quantification of the Kynurenine/Tryptophan Pathway Using Mass Spectrometry Luke Whiley Imperial College London |
Stable Isotope-Dilution-LC-MS/MS-based Reference Methods – Suggestion for Description of Methods and Structure of Analytical Series Michael Vogeser University Hospital, LMU Munich |
Progress in Clinical Applications for the MALDI-Imaging Analysis of Thyroid Biopsies: Evaluation of Proteomic Stability in Preservative Solutions Isabella Piga University of Milano-Bicocca |
MALDI-MSI in the Search for Proteomic Indicators of Response to Therapy in Membranous Nephropathy Andrew Smith University of Milano-Bicocca | ... Keynote ... | ... Extended Session ... | ||
1000 |
Estimation of the Post Mortem Interval via Metabolomic Approach Lyudmila Yanshole International Tomography Center SB RAS |
The Use of Ion Mobility Coupled with High Resolution Mass Spectrometry to Improve Separation and Identification of Lipid Biomarkers in Metabolic Diseases Julian Griffin Department of Biochemistry, University of Cambridge, Cambridge, UK & University of Cagliari, Italy
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Profiling Pathways of Estrogen Metabolism in Patients with Pulmonary Arterial Hypertension: Development of a Novel Assay for Estrogen Metabolites by LC-MS/MS Nina Denver University of Glasgow
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Bringing Mass Spectrometry to Pathologists for Diagnostics of Frozen Surgically Resected Tissue Specimen Tiffany Porta Siegel M4I, Maastricht University | ... Keynote ... | ... Extended Session ... |
1100 | Poster Session 3 @ 1st Floor Exhibit Hall Selected posters to be attended for 1 hour. Refer to program for posters attended during this period. |
1100 | MEET-THE-EXPERTS : Poster Tours @ 1st Floor Exhibit Hall |
1100 | Poster Contest Finalist Interviews @ 1st Floor Exhibit Hall Poster Contest Finalists to attend posters and meet with poster Judges. Judges may arrive in groups or individually. |
Scientific Session 5 |
| Mozart 1-3 Metabolomics – Clinical Studies II | Mozart 4-5 Quantitation Issues | Papageno Clinical Proteomics II | Paracelsus Glycomics Keynote | Trakl Technological Innovations for the Microbiology Laboratory | Doppler Practical Training: Internal Standards | ||
1120 |
Analytical Strategies to Study the Interaction Between Microbiota and Drug Metabolism Using Targeted and Untargeted LC-MS-based Metabolomics Marine Letertre Imperial College London |
Semi-Quantitative LC/ESI/MS Analysis Using Predictive Models of ESI Ionization Efficiencies Jaanus Liigand University of Tartu |
Paving the Way for MS-based Protein Tests that Target Unmet Clinical Needs Christa Cobbaert Leiden University Medical Center |
High-throughput Glycomics in Patient Stratification - What Did We Learn from the First 60,000 Analyses Gordon Lauc University of Zagreb & Genos Glycoscience Research Laboratory, Zagreb, Croatia |
Laser Assisted Rapid Evaporative Ionisation Mass Spectrometry: An Automated Platform for Direct-From-Culture Speciation and Clinical Sample Analysis Simon Cameron Imperial College London |
Everything You Wanted to Know about Internal Standards But Were Too Afraid to Ask Russ Grant Labcorp
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1140 |
Clinical Validation of an Automated Dried Blood Spot Sampling Device – Fluispotter® Khem Adhikari Rigshospitalet |
Quantification and Library Identification of 248 Compounds Commonly Detected in Systematic Toxicology Analysis Using an Automated Extraction Coupled to LC-MS/MS Robin Tiphaine CHU of Limoges |
Combination of Stable Labelled Antibodies and LC-MS to Accurately Quantify Therapeutic Monoclonal Antibodies in the Clinical Laboratory Ravindra Chaudhari PROMISE Advanced Proteomics | ... Keynote ... |
In-situ Detection of the Botulinum Neurotoxin A by Functionalized MALDI Chips Petra Darebna BioCeV | ... Extended Session ... | |
1200 |
Use of Quantitative Metabolomics for Investigation of Age-Related Nuclear Cataracts Vadim Yanshole International Tomography Center SB RAS |
Clinical Mass Spectrometry: the Assessment of Acidosis Profiles and Acute Kidney Injury in Severe Malaria Natthida Sriboonvorakul Mahidol University |
Clinical Analytical Assay for AFP-L3 Using Multiple Reaction Monitoring-Mass Spectrometry for Diagnosing Hepatocellular Carcinoma
Youngsoo Kim Seoul National University College of Medicine | ... Keynote ... |
MALDI-TOF Mass Spectrometry: A Method for the Detection of Bacterial Contamination in Platelet Concentrates Yasmine Chetouane IHU méditerranée infection | ... Extended Session ... |
1330 | Lunch @ 1st Floor Exhibit Hall |
1330 | Poster Session 4 @ 1st Floor Exhibit Hall Selected posters to be attended for 1 hour. Refer to program for posters attended during this period. |
1330 | MEET-THE-EXPERTS : Poster Tours @ 1st Floor Exhibit Hall |
| EXHIBITS CLOSED @ 1st Floor Exhibit Hall |
1415 | Corporate Workshop(s) |
| Tecan @ Papageno (Track 3) Meet our experts in MS sample prep who will present innovative workflows using positive pressure workstations and liquid handling platforms to prep samples for clinical proteomics and steroid analysis. |
1430 | Intermission @ Entrance Foyer |
Scientific Session 6 |
| Mozart 1-3 Metabolomics Keynote | Mozart 4-5 Monitoring Metabolites in Inborn Errors of Metabolism | Papageno Oncology | Paracelsus Tissue Imaging Keynote | Trakl Biomarkers in Infectious Disease | Doppler Practical Training : Getting to Lower Limits of Quantitation | |||
1450 |
How Tandem Mass Spectrometry Revolutionized Newborn Screening David Millington Duke University School of Medicine |
Development of a 2D-UPLC-MS/MS Assay for Therapeutic Monitoring for Patients with APRT Deficiency Unnur Arna Thorsteinsdottir University of Iceland |
Proteomic Analysis of MGL Binding Protein in Human Cancer Cells Martina Pirro Leiden University Medical Center LUMC |
Advances in Computational Methods for Tissue Imaging by Mass Spectrometry Raf Van de Plas Delft University of Technology |
Omics Approaches Towards Discovery of Biomarkers for Early Diagnosis of Tuberculosis Ana Varela Coelho ITQB NOVA
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1/3 Getting Lower Limits of Quantification in LC-MS/MS assays : Prologue Brian Rappold LabCorp
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1510 | ... Keynote ... |
The Role of Chromatography in the Separation of Glucosylceramide Isoforms from Their Isobaric Galactosylceramide Counterparts in the Era of Precision Medicine Christiane Auray-Blais Universite de Sherbrooke |
Exosome-like Vesicles of Uterine Aspirates Permit the Identification of Diagnostic and Stratification Biomarkers of Endometrial Cancer Eva Coll de la Rubia Vall Hebron Research Institute
| ... Keynote ... |
Sepsis by Enterobacteria: A MALDI Affair Markus Kostrzewa Bruker Daltonik GmbH
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2/3 Getting Lower Limits of Quantification in LC-MS/MS assays : Phases and Stages Brian Rappold LabCorp | ||
1530 | ... Keynote ... |
First Experience with a Second-Tier LC-MS/MS Assay for Newborn Screening of Propionic Acidemia, Methylmalonic Acidemias and Combined Remethylation Disorders Glynis Klinke University of Heidelberg |
In Depth Proteomic Analysis of Prostate Cancer Biopsies Gabor Toth Hungarian Academy of Sciences | ... Keynote ... |
Identification and Validation of Two Peptide Markers for the Recognition of Clostridium difficile MLST-1 and MLST-11 by MALDI-MS Simone Nicolardi Leiden University Medical Center |
3/3 Getting Lower Limits of Quantification in LC-MS/MS assays : The Words Don’t Fit the Picture Brian Rappold LabCorp |
1545 | Petite Reception @ Mozart 4-5 Passed beer, wine and other beverages while we prepare for the poster awards. |
1600 | Poster Award Presentation @ Mozart 4-5 |
| 1600 |
Closing Plenary Lecture
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1645 |
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Mass Spectrometric Analysis of Glycomic Signatures of Cancer and Autoimmune Diseases: Towards Clinical Application Manfred Wuhrer LUMC
Many major human diseases including various types of cancer and autoimmune diseases are associated with protein glycosylation changes. These changes are often instrumental in disease development and progression. In cancer, glycosylation changes of both tumor tissues and tumor-derived circulating antigens have been described. However, diagnostic test often merely rely on the measurement of antigen concentrations and fail to register glycosylation changes, largely due to the lack of suitable technology and workflows. In this presentation, examples will be given of recently developed mass spectrometric workflows to determine disease-associated glycosylation changes from tumor tissues and in the circulation, but also from other body fluids including urine and saliva. Promising markers will be presented including immunoglobulin G glycosylation, cancer glycoprotein antigens, as well as tissue glycosylation signatures revealed by mass spectrometry imaging. Steps towards the clinical translation of these markers will be discussed. |
1800 | Closing Reception & Discussion @ Entrance Foyer Wine & Cheese, Beer & Nuts ... and maybe Kaiserschmarrn. Winning posters to be on display. |
2200 | After Congress Meet-Up
@ Your Choice Meet up at the Augustiner Braustubl (Historic Abby turned beer garden with food stalls) for an unofficial and unsponsored post-con gathering. |
