MSACL 2018 EU: Congress Program Salzburg, Austria • September 9 - 13, 2018 With Thanks to Our Corporate Congress Sponsors:     And Special Thanks to Our Travel Grant Sponsors:

= Emerging. More than 5 years before clinical availability. = Expected to be clinically available in 1 to 4 years. = Clinically available now.

Sunday

Sunday 1100 1400

Lunch on Own @ Your Choice Some nearby (within one block) recommendations include: 1. The Heart of Joy (Vegetarian and Vegan) 2. my Indigo Kongresshaus (Asian Fusion) 3. Cafe Fingerlos (Cafe with the best breakfast in town) 4. IMLAUER Sky (Rooftop patio with a view) 5. Cafe Wernbacher (Austrian, great interior for a rainy day with much of the original 1950s decor, open 9am-midnight daily with Sunday Brunch buffet until 2pm) A little further afield: 1. Cafe Sacher (for a patio on the river) 2. Barenwirt (Cozy and Traditional Austrian, fills up so arrive early) 3. Antichi Sapori (Tasty Italian food and pizza in casual family run style, Open 11:30-2:00pm and 5:30-9:00pm, Closed Wed and Thurs) 576

Sunday 1100 1900

Badge Pickup @ Entrance Foyer 574

1400 1800

Short Course

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	COURSE START Data Science 101 Breaking up with Excel: An Introduction to the R Statistical Programming Language Daniel Holmes, MD & William Slade, PhD Level: Beginner - Intermediate @ Mozart 5	COURSE START Data Science 201 Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling Patrick Mathias, MD, PhD & Randall Julian, PhD Level: Intermediate @ Mozart 4	COURSE START LC-MSMS 101 Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory Judy Stone, PhD & Grace van der Gugten Level: Beginner @ Mozart 2	COURSE START LC-MSMS 202 Practical LC-MS Maintenance and Troubleshooting J. Will Thompson, PhD & Erik J. Soderblom, PhD Level: Intermediate @ Paracelsus Hall	COURSE START LC-MSMS 301 Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics Russell Grant, PhD & Brian Rappold Level: Advanced @ Papageno Hall
	COURSE START Metabolomics 202 Metabolomics: Approaches, Applications and Challenges Julijana Ivanisevic, PhD & Elizabeth Want, PhD Level: Beginner to Intermediate @ Doppler Hall	COURSE START Proteomics 201 Clinical Proteomics Cory Bystrom, PhD & Chris Shuford, PhD Level: Intermediate - Advanced @ Trakl Hall

Sunday Every 0:50 for 10 min

Coffee Break @ Entrance Foyer 888

Sunday 1800 1830

Petite Reception @ Entrance Foyer A quick touch of wine and cheese before exploring the city for dinner. 578

Sunday 1800

Dinner on Own @ Your Choice Dinner Suggestions: 1. Gablerbrau (Historic ambiance with traditional food) 2. Augustiner Braustubl (Historic Abby turned beer garden with food stalls) 3. Antichi Sapori (Tasty Italian food and pizza in casual family run style, open 11:30-2:00pm and 5:30-9:00pm, closed Wed and Thurs) 4. Cafe Wernbacher (Austrian, great interior for a rainy day with much of the original 1950s decor, open 9am-midnight daily) After dinner: 1. Murphys Law Irish Pub 579

Sunday 1830 2100

SciCom Discussion Group @ 1st Floor Cafe Private Meeting for Scientific Committee members; includes dinner 577

Monday

Monday 800 900

Welcome Coffee @ Entrance Foyer Enjoy coffee, a pastry and a chat with colleagues before the day starts. 580

900 1300

Short Course

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	Continued from Sunday Data Science 101 Breaking up with Excel: An Introduction to the R Statistical Programming Language Daniel Holmes, MD & William Slade, PhD Level: Beginner - Intermediate @ Mozart 5	Continued from Sunday Data Science 201 Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling Patrick Mathias, MD, PhD & Randall Julian, PhD Level: Intermediate @ Mozart 4	Continued from Sunday LC-MSMS 101 Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory Judy Stone, PhD & Grace van der Gugten Level: Beginner @ Mozart 2	Continued from Sunday LC-MSMS 202 Practical LC-MS Maintenance and Troubleshooting J. Will Thompson, PhD & Erik J. Soderblom, PhD Level: Intermediate @ Paracelsus Hall	Continued from Sunday LC-MSMS 301 Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics Russell Grant, PhD & Brian Rappold Level: Advanced @ Papageno Hall
	Continued from Sunday Metabolomics 202 Metabolomics: Approaches, Applications and Challenges Julijana Ivanisevic, PhD & Elizabeth Want, PhD Level: Beginner to Intermediate @ Doppler Hall	Continued from Sunday Proteomics 201 Clinical Proteomics Cory Bystrom, PhD & Chris Shuford, PhD Level: Intermediate - Advanced @ Trakl Hall

Monday 1300 1400

Lunch @ Entrance Foyer Lunch provided for short course attendees. 589

1400 1800

Short Course

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	COURSE START Lab Medicine 101 Basics of Laboratory Medicine Prof. Dr. med. Michael Vogeser Level: Beginner @ Mozart 3	COURSE START Proteomic Microbiology 201 Bottom-Up and Top-Down Proteomic Approaches for Bacterial Identification and Characterization, a Focus on MALDI-TOF and Advanced Technologies Jean Armengaud, PhD, Stefan Zimmermann, MD Level: Beginner - Intermediate @ Trapp Zimmer	Continued from Monday AM Data Science 101 Breaking up with Excel: An Introduction to the R Statistical Programming Language Daniel Holmes, MD & William Slade, PhD Level: Beginner - Intermediate @ Mozart 5	Continued from Monday AM Data Science 201 Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling Patrick Mathias, MD, PhD & Randall Julian, PhD Level: Intermediate @ Mozart 4	Continued from Monday AM LC-MSMS 101 Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory Judy Stone, PhD & Grace van der Gugten Level: Beginner @ Mozart 2
	Continued from Monday AM LC-MSMS 202 Practical LC-MS Maintenance and Troubleshooting J. Will Thompson, PhD & Erik J. Soderblom, PhD Level: Intermediate @ Paracelsus Hall	Continued from Monday AM LC-MSMS 301 Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics Russell Grant, PhD & Brian Rappold Level: Advanced @ Papageno Hall	Continued from Monday AM Metabolomics 202 Metabolomics: Approaches, Applications and Challenges Julijana Ivanisevic, PhD & Elizabeth Want, PhD Level: Beginner to Intermediate @ Doppler Hall	Continued from Monday AM Proteomics 201 Clinical Proteomics Cory Bystrom, PhD & Chris Shuford, PhD Level: Intermediate - Advanced @ Trakl Hall

Monday 1800 1830

Petite Reception @ Entrance Foyer A quick touch of wine and cheese before exploring the city for dinner. 599

Monday 1800

Dinner on Own @ Your Choice Dinner suggestions: 1. Zum fidelen Affen (best patio dinner on a nice evening, closed Sunday) 2. Die Wiesse (Brewery Pub with beer garden open till 2am Mon-Sat) 3. Gablerbrau (Historic ambiance with traditional food) 4. Augustiner Braustubl (Historic Abby turned beer garden with food stalls) 5. Antichi Sapori (Tasty Italian food and pizza in casual family run style, open 5:30-9:00pm, closed Wed and Thurs) 6. Cafe Wernbacher (Austrian, great interior for a rainy day with much of the original 1950s decor, open 9am-midnight daily) After dinner: 1. Murphys Law Irish Pub 600

Tuesday

Tuesday 800 1600

Place Posters @ 1st Floor Exhibit Hall ALL posters should be placed by 16:00. 601

Tuesday 800 900

Welcome Coffee @ Entrance Foyer Enjoy coffee, a pastry and a chat with colleagues before the day starts. 602

900 1230

Short Course

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	Continued from Monday PM Lab Medicine 101 Basics of Laboratory Medicine Prof. Dr. med. Michael Vogeser Level: Beginner @ Mozart 3	Continued from Monday PM Proteomic Microbiology 201 Bottom-Up and Top-Down Proteomic Approaches for Bacterial Identification and Characterization, a Focus on MALDI-TOF and Advanced Technologies Jean Armengaud, PhD, Stefan Zimmermann, MD Level: Beginner - Intermediate @ Trapp Zimmer	Continued from Monday PM Data Science 101 Breaking up with Excel: An Introduction to the R Statistical Programming Language Daniel Holmes, MD & William Slade, PhD Level: Beginner - Intermediate @ Mozart 5	Continued from Monday PM Data Science 201 Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling Patrick Mathias, MD, PhD & Randall Julian, PhD Level: Intermediate @ Mozart 4	Continued from Monday PM LC-MSMS 101 Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory Judy Stone, PhD & Grace van der Gugten Level: Beginner @ Mozart 2
	Continued from Monday PM LC-MSMS 202 Practical LC-MS Maintenance and Troubleshooting J. Will Thompson, PhD & Erik J. Soderblom, PhD Level: Intermediate @ Paracelsus Hall	Continued from Monday PM LC-MSMS 301 Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics Russell Grant, PhD & Brian Rappold Level: Advanced @ Papageno Hall	Continued from Monday PM Metabolomics 202 Metabolomics: Approaches, Applications and Challenges Julijana Ivanisevic, PhD & Elizabeth Want, PhD Level: Beginner to Intermediate @ Doppler Hall	Continued from Monday PM Proteomics 201 Clinical Proteomics Cory Bystrom, PhD & Chris Shuford, PhD Level: Intermediate - Advanced @ Trakl Hall

Tuesday 1230

CONGRESS OPEN @ Europa Hall 628

Tuesday 1230 1400

Opening Lunch @ Europa Hall 614

Tuesday 1330 1345

Welcome, Introduction & Orientation @ Europa Hall 615

Tuesday 1345 1400

CMS Journal Overview @ Europa Hall An overview on the current state of the journal, how to subscribe, the path to an Impact Factor, citations, scope, desired article format, webinars. 616

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1400	Opening Plenary Lecture @ Europa Hall Chair: Oleg Mayboroda

1400 1445		Metabolomics Messages on Human Health and Disease Jurek Adamski Helmholtz Zentrum M Dr. Adamski studied biochemistry in Poznan, Poland and accomplished his postdoctoral training in endocrinology at the Max-Planck-Institute for Experimental Endocrinology in Hannover, Germany and Karolinska Institutet, Hudinge, Sweden. At present he is director of Genome Analysis Center at the Helmholtz Zentrum Munich and is affiliated as a professor at the Institute of Experimental Genetics at the Technical University of Munich, Germany. Part of his research is performed at the German Center for Diabetes Research (DZD), M The human metabolome represents functional read out of processes in health and disease. The metabolome is both stable and highly dynamic. Stable components are determined by genetics, genomic imprinting or physiological homeostasis. The dynamics originates from circadian rhythm, hormonal status, nutrition, environmental exposure, ageing, medication or disease. Despite its interlaced origin metabolome specifically reflects distinct processes. Metabolomics studies request therefore a special study design. Unique metabolomics signatures have been identified pre-disease (like type 2 diabetes), in disease progression (chronic kidney disease) or in companion diagnostics (drug action monitoring). Metabolomics informed diagnostics has great potential for selectivity, specificity and multiplexing of indications to be screened for.

Tuesday 1445 1500

Coffee Break @ Europa Foyer 618

1500 1600

State of the Science Address @ Europa Hall

Presented by MSACL EU Scientific Committee Topic Leads, this address will provide an overview of the applications and technologies currently being used in Clinical Labs, and a clear view of the development pipeline. It will highlight applications expected to be available in the near-future, as well as emerging applications, and key contributors. Relevant talks, posters, and people present at the congress will be identified, enabling you to optimize your learning path and more effectively target potential network connections. Whether you are new to Clinical Mass Spectrometry, or a seasoned veteran, the State of the Science address should be on your agenda. Brian Keevil (Endocrinology) Manfred Wuhrer (Glycomics) Oleg Mayboroda (Metabolomics) Jean Armengaud (Microbiology) Christa Cobbaert (Proteomics) Michael Vogeser (Small Molecules) Tiffany Porta (Tissue Imaging)

Tuesday 1600 1630

Coffee Break @ Europa Foyer 620

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Tuesday 1630 1700

Poster Lightning Talks @ Europa Hall 15-20 poster presenters will be selected to present their pitch from the plenary podium within 90 seconds and with 1 slide (PDF format). 622

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Tuesday 1700 1730

Exhibitor Lightning Talks @ Europa Hall 15-20 exhibitors will be selected to present their pitch from the plenary podium within 90 seconds and with 1 slide (PDF format). 621

Tuesday 1730

EXHIBITS OPEN @ 1st Floor Exhibit Hall 624

Tuesday 1730 2000

Exhibitor Reception @ 1st Floor Exhibit Hall Buffet dinner served. 623

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Tuesday 1800 1900

MEET-THE-EXPERTS : Booth Tours @ 1st Floor Exhibit Hall Join an expert as they tour the booths and learn more about technologies available, what experts are looking for during the exchange, and how they interact with the booth vendors. Increase your network and your knowledge of products and services available. 625

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1900 2000

Troubleshooting Poster Rounds : Part I @ 1st Floor Exhibit Hall

19:00 @ poster #25a What Happened to My Topiramate? Magdalena Rajska SPADIA Lab, a.s.

19:15 @ poster #25b Optimizing Chromatographic Conditions for HILIC Analysis of Catecholamines Gareth Hammond Waters Corporation

19:30 @ poster #25c An Alternative Solution to High Blank Problems Anne Schmedes Department of Clinical Biochemistry

2000 2200

Discussion Group @ Mozart 4-5

Tuesday 2200

Enjoy the City @ Your Choice or get a good night's sleep 627

Wednesday

Wednesday 745 900

Welcome Coffee @ Entrance Foyer Enjoy coffee, a pastry and a chat with colleagues before the day starts. 603

800 845

Corporate Workshop(s)

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Thermo Scientific @ Papageno (Track 3) Pre-Register Targeted Screening and Semi-Quantitation of Drugs in Plasma using High-Resolution Accurate-Mass Detection and Online Sample Preparation Sensitive and selective analytical methods are required in clinical research and forensic toxicology to properly identify a broad range of analytes in complex matrices. The existing methods need to be constantly updated as new compounds, such as designer drugs, become readily available to the illicit drug market. Liquid chromatography coupled to mass spectrometry (LC-MS) has been widely used in this area for years. So far, the preferred detection technology has been triple quadrupole MS for its selectivity in selected reaction monitoring (SRM) mode. However, this approach suffers from the limitation of being able to perform only targeted analysis, while not being useful for unknown screening of new drugs. Come to our educational seminar to learn more. For Research Use Only. Not for use in diagnostic procedures.

SCIEX @ Paracelsus (Track 4) Pre-Register A Clinical Method for Determination of Anti-Infectious Drugs in Serum Anders Blomgren Associate professor at Division of Clinical Chemistry and Pharmacology, Lund University The initiative for this work was taken by physicians from four different disciplines; intensive care, clinics for infection, thorax and transplantation. There has been an unmet need for these types of analysis and especially with short response times. A TDM wish list was produced that containing about 25 different anti-infection drugs and we agreed on starting to develop methods for 7 of them as a first step. During this talk the following will be presented. • Introduction • Analytes – chemistry/properties/stability • LC, MS and Sample prep development and problem solving • Validation with results • Conclusion and future

Wednesday 845 900

Intermission @ Entrance Foyer 633

Scientific Session 1

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	Track 1 Mozart 1-3 Lipidomics Chair: Julijana Ivanisevic	Track 2 Mozart 4-5 Disease Implications and Diagnosis Chair: Grace van der Gugten	Track 3 Papageno Proteomics Keynote Chair: Christa Cobbaert	Track 4 Paracelsus New Technologies Chair: Vladimir Frankevich	Track 5 Trakl Endocrinology Chair: Flaminia Fanelli	Track 6 Doppler Practical Training : Proteomic Assay Development Chair: Tim Collier
900 920	Defining Boundaries of Lipidomic Variations in Human Cohorts - Federico Torta National University of Singapore	Simultaneous and Automated LC-MS Analysis of Plasma Methylmalonic Acid and Short Chain Fatty Acids Using a Carbodiimide-based Derivatization - Mark Pratt University Medical Center Groningen	Clinical Proteomics: The Path Towards Implementation - Harald Mischak mosaiques therapeutics GmbH & University of Glasgow	Probing Amyloid Aggregation Dynamics in vivo, Using SILK Imaging (iSILK) - Jörg Hanrieder University of Gothenburg	Evaluation of Age and Metabolic Status Impact on Serum Steroid Hormones and Product/Precursor Ratios for the Generation of LC-MS/MS Reference Interval in Men - Marco Mezzullo University of Bologna	Proteomic Assay Development: Digest Optimization and Quality Control - Timothy Collier Quest Diagnostics - Cleveland HeartLab
920 940	Shotgun Lipidomics of Cerebrospinal Fluid in Neurological Disorders - Gábor Balogh Biological Research Centre, Hungarian Academy of Sciences	Mitochondrial Proteins as Parkinson’s Disease Circulatory Biomarkers – a Translational Study - Sandra Anjo University of Coimbra (CNC-UC) Notice: Undefined variable: slides_info_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 Notice: Undefined variable: slides_audio_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 Notice: Undefined variable: info_audio_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 Replacing A. Gaudl. Different Abstract.	... Keynote, continued ...	Identifying Biomarkers in FFPE Breast TMAs Using DESI-MSI - Ólöf Gerdur Ísberg University of Iceland	Quantification of Testosterone, Androstenedione and 17-Hydroxyprogesterone Collected Using Mitra Micro Sampling Devices - David Marshall Manchester University NHS Foundation Trust	... Extended Session ...
940 1000	Understanding the Interplay Between Inflammatory Lipid Signaling and Demyelination Process: A Lipidomics Approach Applied to 3D Human Brain Model - Maria Laura Santoru University of Cagliari / University of Lausanne	The Singapore Lipidomics Incubator: A Model for Engagement and Translation - Anne Bendt National University of Singapore	... Keynote, continued ...	MALDI Imaging Through Laser-Induced Post-Ionization Pushes the Boundaries of Pharmaceutical Development Studies - Florian Barré M4I, Maastricht University	Direct Analysis - No Sample Preparation - of Bioavailable Cortisol in Human Plasma by Weak Affinity Chromatography (WAC; Affinity LC/MS) - Sten Ohlson Nanyang Technological University	... Extended Session ...

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Wednesday 1000 1100

Poster Session 1 @ 1st Floor Exhibit Hall Selected posters to be attended for 1 hour. Refer to program for posters attended during this period. 692

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Wednesday 1000 1100

MEET-THE-EXPERTS : Poster Tours @ 1st Floor Exhibit Hall 703

Scientific Session 2

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	Track 1 Mozart 1-3 Metabolomics Methodology Chair: Elizabeth Want	Track 2 Mozart 4-5 All About Breath Analysis Chair: Neus Fabregat-Cabello	Track 3 Papageno Endocrine Keynote Chair: Brian Keevil	Track 4 Paracelsus Glycomics 1 Chair: Guinevere Lageveen-Kammeijer	Track 5 Trakl MS/MS for Proteotyping Pathogens Chair: Simon Cameron	Track 6 Doppler Practical Training : Calibrators and Internal Standards for Protein MS Chair: Chris Shuford
1100 1120	New Insights in CE-MS-based Metabolomics - Nicolas Drouin University of Geneva	Mass Spectrometry Applied to Large-Scale Multi-Centre Clinical Project in Breath Research - Ilaria Belluomo Imperial College London	Mass Spectrometry Harmonisation: Paediatric Steroid Tales - Ronda Greaves Murdoch Children's Research Institute	Global Glycoproteomic Analysis of O-glycosylation in Human Herpesviruses - Ieva Bagdonaite University of Copenhagen	Phylopeptidomics: A Step Closer to Adopting the Microbiome Data into Clinical Practice - Lucia Grenga CEA	Calibrators and Internal Standards in Protein Mass Spectrometry Assays: Differences, Commonalities, and Best-Practice - Christopher Shuford Laboratory Corporation of America Notice: Undefined variable: slides_info_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 Notice: Undefined variable: slides_audio_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 Notice: Undefined variable: info_audio_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 View Slides (PDF)
1120 1140	Combined Targeted and Untargeted Strategy for Quantification of Amino Acids and Acylcarnitines in Clinically Relevant Biofluids and Tissue Lysates - Vera van der Velpen Metabolomics Unit, University of Lausanne	Cross Platform Validation of Mass Spectrometry for the Diagnosis of Colorectal Cancer Using a Breath Test - Georgia Woodfield Imperial College London	... Keynote, continued ...	In Depth O-Glycosylation Structural Analysis of Colorectal Cancer Cell Lines - Katarina Madunic Leiden University Medical Center	Characterization of the Virulome of Staphylococcus Aureus by a Highly Multiplex Approach with Scout-MRM - Mouton Nicolas University de Lyon Claude Bernard	... Extended Session ...
1140 1200	Development of a Pipeline for Automated Reconstruction and Annotation of Data Independent Acquisition LC-MS Datasets - Gonçalo Graça Imperial College London	A Pilot Study Profiling Volatile Organic Compounds (VOCs) in the Breath of Patients with CRC Using Proton Transfer Mass Spectrometry - Harrypal Panesar Imperial College London	... Keynote, continued ...	HT UPLC Profiling of Total Plasma N-Glycans in Type II Diabetes Mellitus from Patients and Healthy Individuals in a Ghanaian Population - Elham Memarian Leiden University medical centre	Deciphering MALDI-TOF Identification of Bacteria Using a Proteogenomic Approach - Frédéric Jauffrit Université de Lyon	... Extended Session ...

Wednesday 1200 1330

Lunch @ 1st Floor Exhibit Hall Lunch to be provided in the Exhibit Hall. Get ready to join a Corporate Workshop after lunch. 672

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1230 1330

Troubleshooting Poster Rounds : Part II @ 1st Floor Exhibit Hall

12:30 @ poster #26a Metformin Interference in LC-MS/MS Analysis of Plasma Methoxycatecholamines Marianne Bergmann Lillebaelt Hospital, Vejle

12:45 @ poster #26b Charge Wars of Ion Suppression - Awakening the Force for the Analysis of Estrogens in Clinical Research Robert Wardle Waters Corporation

13:00 @ poster #26c Cortisol Everywhere! Neus Fabregat-Cabello University of Liège, CHU de Liège

13:15 @ poster #26d Deuterium or 13C-labeled internal standards for quantification of methylmalonic acid in serum? Morten Trelle Department of Clinical Biochemistry, OUH Svendborg

1330 1415

Corporate Workshop(s)

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Shimadzu @ Mozart 1-3 (Track 1) Pre-Register Better Ways of Working in Routine Clinical Pathology Laboratories Healthcare is dynamic and knows no bounds and so routine clinical pathology laboratories face increasing pressures on cost, time and delivering actionable data. At Shimadzu, we believe there's always a way to make life better. This seminar explores a few options to make a difference. 1) Neil LOFTUS - SHIMADZU Corporation, UK Expanding the capability of mass spectrometry in routine clinical pathology – creating better ways of delivering actionable data. 2) Andrea Radeljak, Matea Ivić – KB Merkur, Croatia Automating standardized workflows in the clinical laboratory – using the Shimadzu CLAM-2000 integrated with LC-MS/MS to help increase sample throughput and make it easier for users. 3) Sigrid BAUMGARTEN - Alsachim SAS, France From core expertise of Stable Isotope Labelled Compounds to reagent kits for high quality LCMS data Disclaimer: For Research Use Only. Not for use in diagnostic procedures. Not available in the USA, Canada and China.

Thermo Scientific @ Mozart 4-5 (Track 2) Pre-Register Fully Automated LC-MS – Theory becomes Reality The use of LC-MS in diagnostic pathology has been limited by the complexity of equipment, materials and skills required to establish a fully validated service. A review showed only 19% of respondents were running VitaminD using LC-MS. On the basis that this is the gold standard, a fully validated and simple-to-use mass spectrometer has been a long awaited development. This presentation shares the first practical experience of using the Thermo Scientific™ Cascadion™ SM Clinical Analyser, in a laboratory, where staff have no prior experience of using LC-MS technology. Automated LC-MS/MS: A disruptive technology will improve the quality of care for our patients The LC-MS/MS platform provides solutions to complex analytical problems for clinical routine laboratories. This development started decades ago and the technology has proven to deliver reliable results with unreached specificity in TDM, DoA testing, endocrine diagnostics and newborn screening. In this presentation the concept of a fully integrated and automated LC-MS/MS is described. Special focus is on features of the Thermo Scientific™ Cascadion™ SM Clinical Analyzer that can overcome the limitations of open systems. Product IVD/CE-marked. Product not 510(k) cleared and not yet available for sale in the US.

Agilent Technologies @ Paracelsus (Track 4) Pre-Register Developing and Delivering Advanced Protein Biomarker Tests for an Era of Precision Medicine Speaker: Prof. Stephen R Pennington, Senior Fellow UCD Conway Institute, University College Dublin, Ireland This presentation will address the key issues around the development of protein signatures in areas of significant unmet clinical need and potential strategies for the delivery and implementation of multiplexed protein biomarkers in a diagnostic setting. View abstract For Research Use Only. Not for use in diagnostic procedures.

Waters @ Trakl (Track 5) Pre-Register Determination of Steroid Hormones in biological matrices by Tandem Mass Spectrometry The determination of steroid hormones in biological matrices requires high analytical sensitivity and is particularly challenging due to analytical interferences from structurally related steroid hormones and synthetic derivatives. LC-MS/MS can provide the analytical sensitivity, selectivity and precision required to enable accurate quantification of organic compounds in human biological liquid matrices. As a leading clinical LC-MS/MS solutions partner, Waters is a trusted provider of in vitro diagnostic medical devices, consumables, informatics, and support services for high performance LC-MS/MS systems. Join us at this workshop to gain insights into how our customers have addressed the challenging analysis of steroid hormones by implementing Waters solutions. LC-MS/MS Analysis of Steroids in the Clinical Laboratory Dr. Brian Keevil, University Hospital of South Manchester , Biochemistry Department Download Dr. Keevil's abstract For Research Use Only. Not for use in diagnostic procedures. Learn more on Waters Solutions for LC/MS Analysis

Wednesday 1415 1430

Intermission @ Entrance Foyer 701

Scientific Session 3

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	Track 1 Mozart 1-3 Metabolic Markers Chair: Luke Whiley	Track 2 Mozart 4-5 Small Molecule Keynote Chair: Michael Vogeser	Track 3 Papageno Cardiovascular and Thrombotic Disease Chair: Tim Collier	Track 4 Paracelsus Tissue Imaging Keynote Chair: Tiffany Porta Siegel	Track 5 Trakl Glycomics 2 Chair: TBA	Track 6 Doppler Practical Training : EU Regulations Chair: Brian Keevil
1430 1450	Discovery of Novel Galabiosylceramide-Related Biomarkers of Fabry Disease by Semi-Targeted Metabolomics: the Complex Issue of Structural Isomer Interferences - Michel Boutin Université de Sherbrooke	Tackling Analytical Challenges in Sports Drug Testing by Mass Spectrometric Approaches - Mario Thevis German Sport University, Cologne, Germany European Monitoring Center for Emerging Doping Agents (EuMoCEDA), Cologne/Bonn, Germany	Building Standards for Proteomics: A Targeted Mass Spectrometry Approach for Quantification of Cardiovascular Disease Biomarker in Human Blood - Albert Sickmann ISAS	Combining Mass Spectrometry Imaging & Microproteomics to Investigate Intratumor Heterogeneity - Liam McDonnell Fondazione Pisana per la Scienza ONLUS, Pisa, Italy	In-Depth Characterisation of Heavily Glycosylated Proteins and Their Potential as Colorectal Cancer Biomarkers - Valeriia Kuzyk Vrije Universiteit Amsterdam	EU LC-MS Verification - Brian Keevil Manchester University
1450 1510	Identifying the Metabolic “Achilles Heel” of Adult and Childhood Brain Cancers Using LC-MS-based Metabolite Profiling - Dong-Hyun Kim University of Nottingham	... Keynote, continued ...	Validation of ApolipoProtein A-I Associated Lipoprotein Panel for the Prediction of Cholesterol Efflux Capacity - Cory Bystrom Cleveland HeartLab	... Keynote, continued ...	Development of MS-based Prostate-Specific Antigen Test with In-Depth Glycosylation Analysis - Guinevere S.M. Lageveen-Kammeijer Center for Proteomics and Metabolomics, LUMC Notice: Undefined variable: slides_info_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 Notice: Undefined variable: slides_audio_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 Notice: Undefined variable: info_audio_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 Switched with A Moran	... Extended Session ...
1510 1530	Urinary Biomarkers of Dietary Intake - Quantification of Sugars for Epidemiology Studies Using LC-MS/MS - Nicola Gray University of Reading	... Keynote, continued ...	Defining the Measurands for Antithrombin and its Proteoforms Using Mass Spectrometry Based Techniques - Renee Ruhaak Leiden University Medical Center	... Keynote, continued ...	Characterisation of Prostate-Specific Antigen Isolated from Patients’ Urine - Alan Moran Leiden University Medical Centre Notice: Undefined variable: slides_info_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 Notice: Undefined variable: slides_audio_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 Notice: Undefined variable: info_audio_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 Switched with G Lageveen-Kammeijer	... Extended Session ...

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Wednesday 1530 1630

Poster Session 2 @ 1st Floor Exhibit Hall 678

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Wednesday 1530 1630

MEET-THE-EXPERTS : Poster Tours @ 1st Floor Exhibit Hall 704

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1630	Distinguished Contribution Award Lecture @ Mozart 1-5 Chair: Elizabeth Want & Brian Keevil

1630 1730	On the Award	Mass Spectrometry and the Elucidation of Steroid Metabolome Cedric Shackleton UCSF Benioff Children Dr. Cedric Shackleton has been a fundamental contributor to steroid metabolome analysis by mass spectrometry and has pioneered the technology and its application to the diagnosis of inborn disorders of sterol and steroidogenesis, with major translational impact. His work over 5 decades has defined the steroid metabolome of many congenital steroid disorders from synthetic to metabolic and receptor defects, pioneering the use of GC-MS in steroid profiling over 30 years ago. He has authored more than 350 PubMed-listed research publications and remains highly active, working at the Institute of Metabolism and Systems Research (IMSR) of the University of Birmingham, UK, helping to set up their specialist steroid methods. Furthermore, Dr. Shackleton has had great influence on those he has mentored over the years. Cedric Shackleton obtained his PhD at the University of Edinburgh followed by a post-doc at the Karolinska institute learning GC/MS under Professor Jan Sj Sterols and steroids were among the first biomolecule groups to be studied by mass-spectrometry. The early success of GC separation in 1960 by Sweeley and Horning and the combination of GC and MS by Ragner Ryhage in Stockholm with invention of a technique for separating the bulk of carrier gas from analytes prior to ionization were fundamental. This led in the mid-60s to the first commercial dedicated GC/MS instrument, the LKB 9000. Professor Jan Sj

Wednesday 1730 1930

Exhibitor Reception @ 1st Floor Exhibit Hall Buffet dinner, appetizers and drinks to be provided. Enjoy mingling with colleagues and Exhibitors. Take time to browse the posters. 680

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Wednesday 1830 1930

MEET-THE-EXPERTS : Office Hours Forum @ 1st Floor Cafe Have a question from the congress that you have been itching to ask? Or a problem from work that you want to get feedback on? Or feedback on the congress? Sign up at the registration desk for 15-min blocks to share time and ideas with domain experts in a relaxed setting. 681

1930 2030

Discussion Group @ Papageno Hall

Wednesday 2030

Enjoy the City @ Your Choice 683

Thursday

Thursday 745 900

Welcome Coffee @ Entrance Foyer Enjoy coffee, a pastry and a chat with colleagues before the day starts. 604

800 845

Corporate Workshop(s)

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Zivak Technologies @ Paracelsus (Track 4) Pre-Register From Primary Sample Tubes to Results: World’s First Fully Automated Sample Preparation and Injection UHPLC System Zivak Technologies is delivering solution to manual sample preparation related problems of chromatography analysis and enabling clinical laboratories to make the most of their MS/MS instruments by full automatization. Fully automated Zivak analyzers allow you to get results from primary sample tubes without any user intervention. After the tubes are placed in the sample tray and the analysis is started on the computer, the robotic arms carry out all sample preparation steps, inject the prepared sample to MS/MS and chromatographic run starts. With Zivak analyzers, opening the sample tubes’ caps is never required. Attend the workshop and listen a detailed review of World’s First Walk Away Sample Preparation and Injection UHPLC System Multitasker and Zivak’s Revolutionary VD-200, Fully Automated Vitamin D2-D3 UHPLC Analyzer from Prof. Dr. Ahmet Ceyhan Gören.

Thursday 800 900

SciCom Discussion Group @ 1st Floor Cafe 856

Thursday 845 900

Intermission @ Entrance Foyer 677

Thursday 900 1000

Exhibitor Feedback @ 1st Floor Cafe An opportunity for exhibiting vendors to provide feedback on what worked and what could use improvement. 691

Scientific Session 4

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	Track 1 Mozart 1-3 Metabolomics – Clinical Studies I Chair: Oleg Mayboroda	Track 2 Mozart 4-5 Quality Issues Chair: Anne Bendt	Track 3 Papageno Clinical Chemistry I Chair: Éva Hunyadi-Gulyás	Track 4 Paracelsus MSI for Clinical Applications Chair: Raf Van de Plas	Track 5 Trakl Microbiology Keynote Chair: Jean Armengaud	Track 6 Doppler Practical Training : Finding Your Analyte Chair: Catarina Horro-Pita
900 920	Metabolomic Analysis of Changes in the Serum of Diabetic Patients Caused by Ulcers - Arsenty Melnikov Internatrional Tomography Center SB RAS	Quality Assurance and Quality Control in LC-MS-based Targeted Lipidomics of Human Blood Plasma - Bo Burla National University of Singapore	A Newly Developed LC-MS/MS Method for the Quantitation of Glucagon in Plasma Shows the Lack of Specificity of Former RIA Methods - Jordi Farre-Segura University of Liège, CHU de Liège	Next Generation Sequencing After MALDI MSI – A Feasibility Study - Kristina Schwamborn Institute of Pathology, TU Munich	Tandem MS-Proteotyping: Proteomics- and Genomics-based Characterization and Typing of Infectious Bacteria - Edward Moore University of Gothenburg	Where Did My Analyte Go? – coping with poor solubility and non-specific binding - Catarina Horro Pita LGC, Drug Development Solutions Notice: Undefined variable: slides_info_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 Notice: Undefined variable: slides_audio_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 Notice: Undefined variable: info_audio_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 View Slides (PDF)
920 940	A Metabolite Level View of the Gut-Brain Axis in Dementia and Aging: Quantification of the Kynurenine/Tryptophan Pathway Using Mass Spectrometry - Luke Whiley Imperial College London	Stable Isotope-Dilution-LC-MS/MS-based Reference Methods – Suggestion for Description of Methods and Structure of Analytical Series - Michael Vogeser University Hospital, LMU Munich	Progress in Clinical Applications for the MALDI-Imaging Analysis of Thyroid Biopsies: Evaluation of Proteomic Stability in Preservative Solutions - Isabella Piga University of Milano-Bicocca	MALDI-MSI in the Search for Proteomic Indicators of Response to Therapy in Membranous Nephropathy - Andrew Smith University of Milano-Bicocca	... Keynote, continued ...	... Extended Session ...
940 1000	Estimation of the Post Mortem Interval via Metabolomic Approach - Lyudmila Yanshole International Tomography Center SB RAS	The Use of Ion Mobility Coupled with High Resolution Mass Spectrometry to Improve Separation and Identification of Lipid Biomarkers in Metabolic Diseases - Julian Griffin Department of Biochemistry, University of Cambridge, Cambridge, UK & University of Cagliari, Italy Notice: Undefined variable: slides_info_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 Notice: Undefined variable: slides_audio_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 Notice: Undefined variable: info_audio_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 New Addition	Profiling Pathways of Estrogen Metabolism in Patients with Pulmonary Arterial Hypertension: Development of a Novel Assay for Estrogen Metabolites by LC-MS/MS - Nina Denver University of Glasgow Notice: Undefined variable: slides_info_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 Notice: Undefined variable: slides_audio_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 Notice: Undefined variable: info_audio_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 New Addition	Bringing Mass Spectrometry to Pathologists for Diagnostics of Frozen Surgically Resected Tissue Specimen - Tiffany Porta Siegel M4I, Maastricht University	... Keynote, continued ...	... Extended Session ...

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Thursday 1000 1100

Poster Session 3 @ 1st Floor Exhibit Hall Selected posters to be attended for 1 hour. Refer to program for posters attended during this period. 671

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Thursday 1000 1100

MEET-THE-EXPERTS : Poster Tours @ 1st Floor Exhibit Hall 705

Thursday 1000 1100

Poster Contest Finalist Interviews @ 1st Floor Exhibit Hall Poster Contest Finalists to attend posters and meet with poster Judges. Judges may arrive in groups or individually. 708

Scientific Session 5

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	Track 1 Mozart 1-3 Metabolomics – Clinical Studies II Chair: Nicola Gray	Track 2 Mozart 4-5 Quantitation Issues Chair: Christiane Auray-Blais	Track 3 Papageno Clinical Proteomics II Chair: Renee Ruhaak	Track 4 Paracelsus Glycomics Keynote Chair: Manfred Wuhrer	Track 5 Trakl Technological Innovations for the Microbiology Laboratory Chair: Ed Moore	Track 6 Doppler Practical Training: Internal Standards Chair: Russ Grant
1100 1120	Analytical Strategies to Study the Interaction Between Microbiota and Drug Metabolism Using Targeted and Untargeted LC-MS-based Metabolomics - Marine Letertre Imperial College London	Semi-Quantitative LC/ESI/MS Analysis Using Predictive Models of ESI Ionization Efficiencies - Jaanus Liigand University of Tartu	Paving the Way for MS-based Protein Tests that Target Unmet Clinical Needs - Christa Cobbaert Leiden University Medical Center	High-throughput Glycomics in Patient Stratification - What Did We Learn from the First 60,000 Analyses - Gordon Lauc University of Zagreb & Genos Glycoscience Research Laboratory, Zagreb, Croatia	Laser Assisted Rapid Evaporative Ionisation Mass Spectrometry: An Automated Platform for Direct-From-Culture Speciation and Clinical Sample Analysis - Simon Cameron Imperial College London	Everything You Wanted to Know about Internal Standards But Were Too Afraid to Ask - Russ Grant Labcorp Notice: Undefined variable: slides_info_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 Notice: Undefined variable: slides_audio_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 Notice: Undefined variable: info_audio_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 View Slides (PDF)
1120 1140	Clinical Validation of an Automated Dried Blood Spot Sampling Device – Fluispotter® - Khem Adhikari Rigshospitalet	Quantification and Library Identification of 248 Compounds Commonly Detected in Systematic Toxicology Analysis Using an Automated Extraction Coupled to LC-MS/MS - Robin Tiphaine CHU of Limoges	Combination of Stable Labelled Antibodies and LC-MS to Accurately Quantify Therapeutic Monoclonal Antibodies in the Clinical Laboratory - Ravindra Chaudhari PROMISE Advanced Proteomics	... Keynote, continued ...	In-situ Detection of the Botulinum Neurotoxin A by Functionalized MALDI Chips - Petra Darebna BioCeV	... Extended Session ...
1140 1200	Use of Quantitative Metabolomics for Investigation of Age-Related Nuclear Cataracts - Vadim Yanshole International Tomography Center SB RAS	Clinical Mass Spectrometry: the Assessment of Acidosis Profiles and Acute Kidney Injury in Severe Malaria - Natthida Sriboonvorakul Mahidol University	Clinical Analytical Assay for AFP-L3 Using Multiple Reaction Monitoring-Mass Spectrometry for Diagnosing Hepatocellular Carcinoma - Youngsoo Kim Seoul National University College of Medicine	... Keynote, continued ...	MALDI-TOF Mass Spectrometry: A Method for the Detection of Bacterial Contamination in Platelet Concentrates - Yasmine Chetouane IHU méditerranée infection	... Extended Session ...

Thursday 1200 1330

Lunch @ 1st Floor Exhibit Hall 693

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Thursday 1230 1330

Poster Session 4 @ 1st Floor Exhibit Hall Selected posters to be attended for 1 hour. Refer to program for posters attended during this period. 706

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Thursday 1230 1330

MEET-THE-EXPERTS : Poster Tours @ 1st Floor Exhibit Hall 707

Thursday 1330

EXHIBITS CLOSED @ 1st Floor Exhibit Hall 695

1330 1415

Corporate Workshop(s)

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Tecan @ Papageno (Track 3) Meet our experts in MS sample prep who will present innovative workflows using positive pressure workstations and liquid handling platforms to prep samples for clinical proteomics and steroid analysis. Semi-automated sample processing for clinical proteomics Stefan Loroch, Leibniz Institute for Analytical Sciences (ISAS), Proteomics Facility Powerful automated multi-steroid extraction via positive pressure and liquid handling platform for LC-MS analysis Dr. Christian Scherling, Tecan Germany, MS Sample Prep Application Specialist

Thursday 1415 1430

Intermission @ Entrance Foyer 696

Scientific Session 6

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	Track 1 Mozart 1-3 Metabolomics Keynote Chair: Russ Grant	Track 2 Mozart 4-5 Monitoring Metabolites in Inborn Errors of Metabolism Chair: Zdenek Spacil	Track 3 Papageno Oncology Chair: Yuri van der Burgt	Track 4 Paracelsus Tissue Imaging Keynote Chair: Kristina Schwamborn	Track 5 Trakl Biomarkers in Infectious Disease Chair: Stefan Zimmerman	Track 6 Doppler Practical Training : Getting to Lower Limits of Quantitation Chair: Brian Rappold
1430 1450	How Tandem Mass Spectrometry Revolutionized Newborn Screening - David Millington Duke University School of Medicine	Development of a 2D-UPLC-MS/MS Assay for Therapeutic Monitoring for Patients with APRT Deficiency - Unnur Arna Thorsteinsdottir University of Iceland	Proteomic Analysis of MGL Binding Protein in Human Cancer Cells - Martina Pirro Leiden University Medical Center LUMC	Advances in Computational Methods for Tissue Imaging by Mass Spectrometry - Raf Van de Plas Delft University of Technology	Omics Approaches Towards Discovery of Biomarkers for Early Diagnosis of Tuberculosis - Ana Varela Coelho ITQB NOVA Notice: Undefined variable: slides_info_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 Notice: Undefined variable: slides_audio_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 Notice: Undefined variable: info_audio_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 Switched with M Kostrzewa	1/3 Getting Lower Limits of Quantification in LC-MS/MS assays : Prologue - Brian Rappold LabCorp Notice: Undefined variable: slides_info_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 Notice: Undefined variable: slides_audio_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 Notice: Undefined variable: info_audio_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 View Slides (PDF)
1450 1510	... Keynote, continued ...	The Role of Chromatography in the Separation of Glucosylceramide Isoforms from Their Isobaric Galactosylceramide Counterparts in the Era of Precision Medicine - Christiane Auray-Blais Universite de Sherbrooke	Exosome-like Vesicles of Uterine Aspirates Permit the Identification of Diagnostic and Stratification Biomarkers of Endometrial Cancer - Eva Coll de la Rubia Vall Hebron Research Institute Notice: Undefined variable: slides_info_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 Notice: Undefined variable: slides_audio_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 Notice: Undefined variable: info_audio_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 Replacing Eva Colas. Same Lab & Abstract.	... Keynote, continued ...	Sepsis by Enterobacteria: A MALDI Affair - Markus Kostrzewa Bruker Daltonik GmbH Notice: Undefined variable: slides_info_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 Notice: Undefined variable: slides_audio_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 Notice: Undefined variable: info_audio_br in /home/msacl0017/public_html/program/include_3_talk_include_track.php on line 178 Switched with Ana Varela Coelho	2/3 Getting Lower Limits of Quantification in LC-MS/MS assays : Phases and Stages - Brian Rappold LabCorp
1510 1530	... Keynote, continued ...	First Experience with a Second-Tier LC-MS/MS Assay for Newborn Screening of Propionic Acidemia, Methylmalonic Acidemias and Combined Remethylation Disorders - Glynis Klinke University of Heidelberg	In Depth Proteomic Analysis of Prostate Cancer Biopsies - Gabor Toth Hungarian Academy of Sciences	... Keynote, continued ...	Identification and Validation of Two Peptide Markers for the Recognition of Clostridium difficile MLST-1 and MLST-11 by MALDI-MS - Simone Nicolardi Leiden University Medical Center	3/3 Getting Lower Limits of Quantification in LC-MS/MS assays : The Words Don’t Fit the Picture - Brian Rappold LabCorp

Thursday 1530 1545

Petite Reception @ Mozart 4-5 Passed beer, wine and other beverages while we prepare for the poster awards. 697

Thursday 1545 1600

Poster Award Presentation @ Mozart 4-5 698

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1600	Closing Plenary Lecture @ Mozart 4-5 Chair: Guinevere Lageveen-Kammeijer

1600 1645		Mass Spectrometric Analysis of Glycomic Signatures of Cancer and Autoimmune Diseases: Towards Clinical Application Manfred Wuhrer LUMC Manfred Wuhrer is professor of Proteomics and Glycomics and head of the Center for Proteomics and Metabolomics of the Leiden University Medical Center (LUMC)). He is also chairman of the Dutch Society for Mass Spectrometry (NVMS). Manfred Wuhrer studied Biochemistry at Regensburg University, Germany. He obtained a PhD from Giessen University in 1999 on the Characterization of Stage-Specifically expressed Glycolipids of the Human Parasite Schistosoma mansoni. In 2003 he came to the LUMC establishing a research line on mass spectrometric glycosylation analysis. In 2013 Manfred Wuhrer became Professor Analytics of Biomolecular Interactions at VU University Amsterdam. In 2015 he was appointed Professor in Proteomics and Glycomics at the LUMC heading the Center of Proteomics and Metabolomics. Many major human diseases including various types of cancer and autoimmune diseases are associated with protein glycosylation changes. These changes are often instrumental in disease development and progression. In cancer, glycosylation changes of both tumor tissues and tumor-derived circulating antigens have been described. However, diagnostic test often merely rely on the measurement of antigen concentrations and fail to register glycosylation changes, largely due to the lack of suitable technology and workflows. In this presentation, examples will be given of recently developed mass spectrometric workflows to determine disease-associated glycosylation changes from tumor tissues and in the circulation, but also from other body fluids including urine and saliva. Promising markers will be presented including immunoglobulin G glycosylation, cancer glycoprotein antigens, as well as tissue glycosylation signatures revealed by mass spectrometry imaging. Steps towards the clinical translation of these markers will be discussed.

Thursday 1645 1800

Closing Reception & Discussion @ Entrance Foyer Wine & Cheese, Beer & Nuts ... and maybe Kaiserschmarrn. Winning posters to be on display. 700

Thursday 1800 2200

After Congress Meet-Up @ Your Choice Meet up at the Augustiner Braustubl (Historic Abby turned beer garden with food stalls) for an unofficial and unsponsored post-con gathering. 699