Some nearby (within one block) recommendations include:
1. The Heart of Joy (Vegetarian and Vegan)
2. my Indigo Kongresshaus (Asian Fusion)
3. Cafe Fingerlos (Cafe with the best breakfast in town)
4. IMLAUER Sky (Rooftop patio with a view)
5. Cafe Wernbacher (Austrian, great interior for a rainy day with much of the original 1950s decor, open 9am-midnight daily with Sunday Brunch buffet until 2pm)
A little further afield:
1. Cafe Sacher (for a patio on the river)
2. Barenwirt (Cozy and Traditional Austrian, fills up so arrive early)
3. Antichi Sapori (Tasty Italian food and pizza in casual family run style, Open 11:30-2:00pm and 5:30-9:00pm, Closed Wed and Thurs)
A quick touch of wine and cheese before exploring the city for dinner.
578
Sunday 1800
Dinner on Own @ Your Choice
Dinner Suggestions:
1. Gablerbrau (Historic ambiance with traditional food)
2. Augustiner Braustubl (Historic Abby turned beer garden with food stalls)
3. Antichi Sapori (Tasty Italian food and pizza in casual family run style, open 11:30-2:00pm and 5:30-9:00pm, closed Wed and Thurs)
4. Cafe Wernbacher (Austrian, great interior for a rainy day with much of the original 1950s decor, open 9am-midnight daily)
A quick touch of wine and cheese before exploring the city for dinner.
599
Monday 1800
Dinner on Own @ Your Choice
Dinner suggestions:
1. Zum fidelen Affen (best patio dinner on a nice evening, closed Sunday)
2. Die Wiesse (Brewery Pub with beer garden open till 2am Mon-Sat)
3. Gablerbrau (Historic ambiance with traditional food)
4. Augustiner Braustubl (Historic Abby turned beer garden with food stalls)
5. Antichi Sapori (Tasty Italian food and pizza in casual family run style, open 5:30-9:00pm, closed Wed and Thurs)
6. Cafe Wernbacher (Austrian, great interior for a rainy day with much of the original 1950s decor, open 9am-midnight daily)
An overview on the current state of the journal, how to subscribe, the path to an Impact Factor, citations, scope, desired article format, webinars.
616
1400
Opening Plenary Lecture
@ Europa Hall Chair: Oleg Mayboroda
1400
1445
Metabolomics Messages on Human Health and Disease Jurek Adamski Helmholtz Zentrum M
Dr. Adamski studied biochemistry in Poznan, Poland and accomplished his postdoctoral training in endocrinology at the Max-Planck-Institute for Experimental Endocrinology in Hannover, Germany and Karolinska Institutet, Hudinge, Sweden. At present he is director of Genome Analysis Center at the Helmholtz Zentrum Munich and is affiliated as a professor at the Institute of Experimental Genetics at the Technical University of Munich, Germany. Part of his research is performed at the German Center for Diabetes Research (DZD), M
The human metabolome represents functional read out of processes in health and disease. The metabolome is both stable and highly dynamic. Stable components are determined by genetics, genomic imprinting or physiological homeostasis. The dynamics originates from circadian rhythm, hormonal status, nutrition, environmental exposure, ageing, medication or disease. Despite its interlaced origin metabolome specifically reflects distinct processes. Metabolomics studies request therefore a special study design. Unique metabolomics signatures have been identified pre-disease (like type 2 diabetes), in disease progression (chronic kidney disease) or in companion diagnostics (drug action monitoring). Metabolomics informed diagnostics has great potential for selectivity, specificity and multiplexing of indications to be screened for.
Tuesday 1445
1500
Coffee Break @ Europa Foyer
618
1500
1600
State of the Science Address @ Europa Hall
Presented by MSACL EU Scientific Committee Topic Leads, this address will provide an overview of the applications and technologies currently being used in Clinical Labs, and a clear view of the development pipeline. It will highlight applications expected to be available in the near-future, as well as emerging applications, and key contributors. Relevant talks, posters, and people present at the congress will be identified, enabling you to optimize your learning path and more effectively target potential network connections. Whether you are new to Clinical Mass Spectrometry, or a seasoned veteran, the State of the Science address should be on your agenda.
Brian Keevil (Endocrinology)
Manfred Wuhrer (Glycomics)
Oleg Mayboroda (Metabolomics)
Jean Armengaud (Microbiology)
Christa Cobbaert (Proteomics)
Michael Vogeser (Small Molecules)
Tiffany Porta (Tissue Imaging)
Tuesday 1600
1630
Coffee Break @ Europa Foyer
620
Tuesday 1630
1700
Poster Lightning Talks @ Europa Hall
15-20 poster presenters will be selected to present their pitch from the plenary podium within 90 seconds and with 1 slide (PDF format).
622
Tuesday 1700
1730
Exhibitor Lightning Talks @ Europa Hall
15-20 exhibitors will be selected to present their pitch from the plenary podium within 90 seconds and with 1 slide (PDF format).
621
Tuesday 1730
EXHIBITS OPEN @ 1st Floor Exhibit Hall
624
Tuesday 1730
2000
Exhibitor Reception @ 1st Floor Exhibit Hall
Buffet dinner served.
623
Tuesday 1800
1900
MEET-THE-EXPERTS : Booth Tours @ 1st Floor Exhibit Hall
Join an expert as they tour the booths and learn more about technologies available, what experts are looking for during the exchange, and how they interact with the booth vendors. Increase your network and your knowledge of products and services available.
625
1900
2000
Troubleshooting Poster Rounds : Part I @ 1st Floor Exhibit Hall
Targeted Screening and Semi-Quantitation of Drugs in Plasma using High-Resolution Accurate-Mass Detection and Online Sample Preparation
Sensitive and selective analytical methods are required in clinical research and forensic toxicology to properly identify a broad range of analytes in complex matrices. The existing methods need to be constantly updated as new compounds, such as designer drugs, become readily available to the illicit drug market. Liquid chromatography coupled to mass spectrometry (LC-MS) has been widely used in this area for years. So far, the preferred detection technology has been triple quadrupole MS for its selectivity in selected reaction monitoring (SRM) mode. However, this approach suffers from the limitation of being able to perform only targeted analysis, while not being useful for unknown screening of new drugs.
Come to our educational seminar to learn more.
For Research Use Only. Not for use in diagnostic procedures.
A Clinical Method for Determination of Anti-Infectious Drugs in Serum
Anders Blomgren Associate professor at Division of Clinical Chemistry and Pharmacology, Lund University
The initiative for this work was taken by physicians from four different disciplines; intensive care, clinics for infection, thorax and transplantation. There has been an unmet need for these types of analysis and especially with short response times. A TDM wish list was produced that containing about 25 different anti-infection drugs and we agreed on starting to develop methods for 7 of them as a first step.
During this talk the following will be presented.
• Introduction
• Analytes – chemistry/properties/stability
• LC, MS and Sample prep development and problem solving
• Validation with results
• Conclusion and future
Wednesday 845
900
Intermission @ Entrance Foyer
633
Scientific Session 1
Track 1 Mozart 1-3
Lipidomics Chair: Julijana Ivanisevic
Track 2 Mozart 4-5
Disease Implications and Diagnosis Chair: Grace van der Gugten
Track 3 Papageno
Proteomics Keynote Chair: Christa Cobbaert
Track 4 Paracelsus
New Technologies Chair: Vladimir Frankevich
Track 5 Trakl
Endocrinology Chair: Flaminia Fanelli
Track 6 Doppler
Practical Training : Proteomic Assay Development Chair: Tim Collier
Better Ways of Working in Routine Clinical Pathology Laboratories
Healthcare is dynamic and knows no bounds and so routine clinical pathology laboratories face increasing pressures on cost, time and delivering actionable data.
At Shimadzu, we believe there's always a way to make life better. This seminar explores a few options to make a difference.
1) Neil LOFTUS - SHIMADZU Corporation, UK Expanding the capability of mass spectrometry in routine clinical pathology – creating better ways of delivering actionable data.
2) Andrea Radeljak, Matea Ivić – KB Merkur, Croatia Automating standardized workflows in the clinical laboratory – using the Shimadzu CLAM-2000 integrated with LC-MS/MS to help increase sample throughput and make it easier for users.
3) Sigrid BAUMGARTEN - Alsachim SAS, France From core expertise of Stable Isotope Labelled Compounds to reagent kits for high quality LCMS data
Disclaimer: For Research Use Only. Not for use in diagnostic procedures. Not available in the USA, Canada and China.
The use of LC-MS in diagnostic pathology has been limited by the complexity of equipment, materials and skills required to establish a fully validated service. A review showed only 19% of respondents were running VitaminD using LC-MS. On the basis that this is the gold standard, a fully validated and simple-to-use mass spectrometer has been a long awaited development. This presentation shares the first practical experience of using the Thermo Scientific™ Cascadion™ SM Clinical Analyser, in a laboratory, where staff have no prior experience of using LC-MS technology.
Automated LC-MS/MS: A disruptive technology will improve the quality of care for our patients
The LC-MS/MS platform provides solutions to complex analytical problems for clinical routine laboratories. This development started decades ago and the technology has proven to deliver reliable results with unreached specificity in TDM, DoA testing, endocrine diagnostics and newborn screening. In this presentation the concept of a fully integrated and automated LC-MS/MS is described. Special focus is on features of the Thermo Scientific™ Cascadion™ SM Clinical Analyzer that can overcome the limitations of open systems.
Product IVD/CE-marked. Product not 510(k) cleared and not yet available for sale in the US.
Developing and Delivering Advanced Protein Biomarker Tests for an Era of Precision Medicine
Speaker: Prof. Stephen R Pennington, Senior Fellow UCD Conway Institute, University College Dublin, Ireland
This presentation will address the key issues around the development of protein signatures in areas of significant unmet clinical need and potential strategies for the delivery and implementation of multiplexed protein biomarkers in a diagnostic setting.
Determination of Steroid Hormones in biological matrices by Tandem Mass Spectrometry
The determination of steroid hormones in biological matrices requires high analytical sensitivity and is particularly challenging due to analytical interferences from structurally related steroid hormones and synthetic derivatives. LC-MS/MS can provide the analytical sensitivity, selectivity and precision required to enable accurate quantification of organic compounds in human biological liquid matrices.
As a leading clinical LC-MS/MS solutions partner, Waters is a trusted provider of in vitro diagnostic medical devices, consumables, informatics, and support services for high performance LC-MS/MS systems.
Join us at this workshop to gain insights into how our customers have addressed the challenging analysis of steroid hormones by implementing Waters solutions.
LC-MS/MS Analysis of Steroids in the Clinical Laboratory Dr. Brian Keevil, University Hospital of South Manchester , Biochemistry Department
Mass Spectrometry and the Elucidation of Steroid Metabolome Cedric Shackleton UCSF Benioff Children
Dr. Cedric Shackleton has been a fundamental contributor to steroid metabolome analysis by mass spectrometry and has pioneered the technology and its application to the diagnosis of inborn disorders of sterol and steroidogenesis, with major translational impact. His work over 5 decades has defined the steroid metabolome of many congenital steroid disorders from synthetic to metabolic and receptor defects, pioneering the use of GC-MS in steroid profiling over 30 years ago. He has authored more than 350 PubMed-listed research publications and remains highly active, working at the Institute of Metabolism and Systems Research (IMSR) of the University of Birmingham, UK, helping to set up their specialist steroid methods. Furthermore, Dr. Shackleton has had great influence on those he has mentored over the years.
Cedric Shackleton obtained his PhD at the University of Edinburgh followed by a post-doc at the Karolinska institute learning GC/MS under Professor Jan Sj
Sterols and steroids were among the first biomolecule groups to be studied by mass-spectrometry. The early success of GC separation in 1960 by Sweeley and Horning and the combination of GC and MS by Ragner Ryhage in Stockholm with invention of a technique for separating the bulk of carrier gas from analytes prior to ionization were fundamental. This led in the mid-60s to the first commercial dedicated GC/MS instrument, the LKB 9000. Professor Jan Sj
Wednesday 1730
1930
Exhibitor Reception @ 1st Floor Exhibit Hall
Buffet dinner, appetizers and drinks to be provided.
Enjoy mingling with colleagues and Exhibitors. Take time to browse the posters.
680
Wednesday 1830
1930
MEET-THE-EXPERTS : Office Hours Forum @ 1st Floor Cafe
Have a question from the congress that you have been itching to ask? Or a problem from work that you want to get feedback on? Or feedback on the congress? Sign up at the registration desk for 15-min blocks to share time and ideas with domain experts in a relaxed setting.
681
1930
2030
Discussion Group @ Mozart 4-5
Wednesday 2030
Enjoy the City @ Your Choice
683
Thursday
Thursday 745
900
Welcome Coffee @ Entrance Foyer
Enjoy coffee, a pastry and a chat with colleagues before the day starts.
From Primary Sample Tubes to Results: World’s First Fully Automated Sample Preparation and Injection UHPLC System
Zivak Technologies is delivering solution to manual sample preparation related problems of chromatography analysis and enabling clinical laboratories to make the most of their MS/MS instruments by full automatization.
Fully automated Zivak analyzers allow you to get results from primary sample tubes without any user intervention. After the tubes are placed in the sample tray and the analysis is started on the computer, the robotic arms carry out all sample preparation steps, inject the prepared sample to MS/MS and chromatographic run starts. With Zivak analyzers, opening the sample tubes’ caps is never required.
Attend the workshop and listen a detailed review of World’s First Walk Away Sample Preparation and Injection UHPLC System Multitasker and Zivak’s Revolutionary VD-200, Fully Automated Vitamin D2-D3 UHPLC Analyzer from Prof. Dr. Ahmet Ceyhan Gören.
Thursday 800
900
SciCom Discussion Group @ 1st Floor Cafe
856
Thursday 845
900
Intermission @ Entrance Foyer
677
Thursday 900
1000
Exhibitor Feedback @ 1st Floor Cafe
An opportunity for exhibiting vendors to provide feedback on what worked and what could use improvement.
691
Scientific Session 4
Track 1 Mozart 1-3
Metabolomics – Clinical Studies I Chair: Oleg Mayboroda
Track 2 Mozart 4-5
Quality Issues Chair: Anne Bendt
Track 3 Papageno
Clinical Chemistry I Chair: Éva Hunyadi-Gulyás
Track 4 Paracelsus
MSI for Clinical Applications Chair: Raf Van de Plas
Track 5 Trakl
Microbiology Keynote Chair: Jean Armengaud
Track 6 Doppler
Practical Training : Finding Your Analyte Chair: Catarina Horro-Pita
Selected posters to be attended for 1 hour. Refer to program for posters attended during this period.
706
Thursday 1230
1330
MEET-THE-EXPERTS : Poster Tours @ 1st Floor Exhibit Hall
707
Thursday 1330
EXHIBITS CLOSED @ 1st Floor Exhibit Hall
695
1330
1415
Corporate Workshop(s)
Tecan @ Papageno (Track 3)
Meet our experts in MS sample prep who will present innovative workflows using positive pressure workstations and liquid handling platforms to prep samples for clinical proteomics and steroid analysis.
Semi-automated sample processing for clinical proteomics Stefan Loroch, Leibniz Institute for Analytical Sciences (ISAS), Proteomics Facility
Powerful automated multi-steroid extraction via positive pressure and liquid handling platform for LC-MS analysis Dr. Christian Scherling, Tecan Germany, MS Sample Prep Application Specialist
Thursday 1415
1430
Intermission @ Entrance Foyer
696
Scientific Session 6
Track 1 Mozart 1-3
Metabolomics Keynote Chair: Russ Grant
Track 2 Mozart 4-5
Monitoring Metabolites in Inborn Errors of Metabolism Chair: Zdenek Spacil
Track 3 Papageno
Oncology Chair: Yuri van der Burgt
Track 4 Paracelsus
Tissue Imaging Keynote Chair: Kristina Schwamborn
Track 5 Trakl
Biomarkers in Infectious Disease Chair: Stefan Zimmerman
Track 6 Doppler
Practical Training : Getting to Lower Limits of Quantitation Chair: Brian Rappold
Passed beer, wine and other beverages while we prepare for the poster awards.
697
Thursday 1545
1600
Poster Award Presentation @ Mozart 4-5
698
1600
Closing Plenary Lecture
@ Mozart 4-5 Chair: Guinevere Lageveen-Kammeijer
1600
1645
Mass Spectrometric Analysis of Glycomic Signatures of Cancer and Autoimmune Diseases: Towards Clinical Application Manfred Wuhrer LUMC
Manfred Wuhrer is professor of Proteomics and Glycomics and head of the Center for Proteomics and Metabolomics of the Leiden University Medical Center (LUMC)). He is also chairman of the Dutch Society for Mass Spectrometry (NVMS).
Manfred Wuhrer studied Biochemistry at Regensburg University, Germany. He obtained a PhD from Giessen University in 1999 on the Characterization of Stage-Specifically expressed Glycolipids of the Human Parasite Schistosoma mansoni. In 2003 he came to the LUMC establishing a research line on mass spectrometric glycosylation analysis.
In 2013 Manfred Wuhrer became Professor Analytics of Biomolecular Interactions at VU University Amsterdam. In 2015 he was appointed Professor in Proteomics and Glycomics at the LUMC heading the Center of Proteomics and Metabolomics.
Many major human diseases including various types of cancer and autoimmune diseases are associated with protein glycosylation changes. These changes are often instrumental in disease development and progression. In cancer, glycosylation changes of both tumor tissues and tumor-derived circulating antigens have been described. However, diagnostic test often merely rely on the measurement of antigen concentrations and fail to register glycosylation changes, largely due to the lack of suitable technology and workflows. In this presentation, examples will be given of recently developed mass spectrometric workflows to determine disease-associated glycosylation changes from tumor tissues and in the circulation, but also from other body fluids including urine and saliva. Promising markers will be presented including immunoglobulin G glycosylation, cancer glycoprotein antigens, as well as tissue glycosylation signatures revealed by mass spectrometry imaging. Steps towards the clinical translation of these markers will be discussed.
Thursday 1645
1800
Closing Reception & Discussion @ Entrance Foyer
Wine & Cheese, Beer & Nuts ... and maybe Kaiserschmarrn.
Winning posters to be on display.
700
Thursday 1800
2200
After Congress Meet-Up
@ Your Choice
Meet up at the Augustiner Braustubl (Historic Abby turned beer garden with food stalls) for an unofficial and unsponsored post-con gathering.
= Discovery stage.
= Translation stage.
= Clinically available.
COURSE START 
