MSACL 2020 US : Conference Program Palm Springs, CA • March 29 - April 3, 2020

Abstract Clinical Use Status Key

= Discovery stage. = Translation stage. = Clinically available.

SUN Short Courses MON Short Courses TUE Short Courses Get-the-Basics Opening Plenary WED Scientific Sessions THU Scientific Sessions FRI Scientific Sessions IMSS Focus ALL View All Posters View Abstracts by Topic Cases in Clinical MSData ScienceGlycomicsImagingLipidomicsMetabolomicsMicrobiologyNatural Products / EnvironmentalPractical TrainingProteomicsTox / TDM / EndocrineTroubleshootingVarious OTHER View Abstracts by Presenter Abdel Rahman, AnasAkin, JoshuaAlexandrov, TheodoreAnderton, ChristopherAndren, PerAngel, PeggiAntunes, Natalicia De JesusAraiza, RobynBadea, AdinaBajaj, AmolBalogun, KayodeBaniasad, MaryamBarbhuiya, MustafaBasu, SankhaBazydlo, LindsayBensussan, AlenaBeppler, BenjaminBerdyshev, EvgenyBerner, CamilaBlack, AlysonBlaschke, CalvinBorden, ScottBoslett, JamesBotre, FrancescoBrewer, WilliamBunch, DustinBurdman, IljaBurla, BoCaudy, AmyChambers, TinaChen, DawnChopra, GauravClark, ZlataClarke, JoeClift, CassandraCody, RobertCostello, CatherineCox, ChrisCox, HollyCrawford, MatthewDasari, Surendrade Rijke, YolandaDee, StacyDelacourt, AndrewDelaney, SarahDeMarco, MariDjambazova, KaterinaDolin, ChristineDomenick, TaylorDong, XiaoliDubland, JoshuaEkroos, KimFagerquist, CliftonFatica, EricaFeickert, MartinFeng, ShengFoley, DominicFord, LisaFoster, MakaylaFournier, IsabelleFranco, JackelineFrank, ElizabethFranks, CarolineGairloch, ElenaGangnus, TanjaGardner, JennaGarnett, EmilyGarza, KyanaGauthier, JeannetteGeistanger, AndreaGhoshal, AmitGill, ChrisGionfriddo, EmanuelaGomez, GermanGrant, RussGu, HaiweiGuiberson, EmmaGuo, DanGurtner, KariHackett, TillieHall, ZoeHampton, WesleyHauck, ZaneHavlicek, VladimirHeller, CarolinHerold, ChrisHigashi, RichardHigginson, JamesHill, CollinHitchcock, JenniferHoffman, MelissaHooshfar, ShirinHu, YuemingHuang, RongHughey, JakeHuq, ShahanaIannella, LoredanaIannone, MicheleJanis, GregoryJanssen, NatasjaJarvis, MichaelJasbi, PanizJenkinson, CarlJensen, TrinitiJin, ZhichengJones, E. EllenJones, MarissaKaufmann, MartinKe, YilingKemp, JenniferKemperman, RobinKertesz, VilmosKetha, HemaKhan, KhalidKing, MaryKirkpatrick, LindseyKirkwood, KaylieKivi, NiinaKoch, ChristopherKondethimmanahalli, ChandramouliKoomen, JohnKrieger, AnnaKumar, PraveenKushnir, MarkLadwig, PaulaLarkey, NicholasLassman, MichaelLaude, NicholasLaw, Ka Kiu NatalieLawrence, KentLi, LingjunLiao, Hsuan-Chieh (Joyce)Lima, HeatherLin, Tai-DuLopez, DiegoLukowski, JessicaLuo, Y. RubenLy, DianeMaljers, LouisMargulis, KatyMarin, StephanieMays, AlexMc Ardle, AngelaMcCall, HollyMcminn, MadisonMehta, AnandMehta, KhyatiMellinger, AllysonMemarian, ElhamMichno, WojciechMilan, DanMiller, AnnaMishra, UshaMoorthy, GaneshMoser, KellyMoshin, JennyMotorykin, IevgenMuddiman, DavidNajar, AhmedNedelkov, DobrinNetzel, BrianNierychlewski, KajetanNikitina, ArinaNoguez, JaimeOdenkirk, MelanieOgrinc, NinaOkoye, NkemakonamOrton, DennisOwusu, BenjaminPablo, AbedPace, CrystalPamreddy, AnnapurnaParra, NaPatterson, JeffreyPetritis, KonstantinosPickens, AustinPlubell, DeannaPovilaitis, SydneyQuint, PatrickRay, JulieRay, KevinReckers, AndrewRehse, MarkRoper, StephenRosano, ThomasRose, MelanieSadilkova, KaterinaSalzet, MichelSamra, StephanieSaucier, Leigh AnnSaxena, GautamSchauer, AmandaSchey, KevinSekera, EmilyShrestha, BindeshShugarts, SarahSimon, FabianSkaggs, ChristineSmith, JeremySnow, LauraSpivia, WestonSreenivasan, UmaStevens, ShaneStone, JudithStumpo, KatherineSuhandynata, RaymondSuhr, Anna CatharinaSullards, CameronSweedler, JonathanSzczesniewski, AndreTarolli, JayTeehan, Katie-JoThan, Nandor GaborThompson, J. WillTilley, SloaneTurner, Cassidyvan Breemen, Richardvan den Broek, Irenevan der Drift, Koenvan Natta, KristineVitek, OlgaWalker, KatherineWang, DaojingWang, MengWang, YuesongWant, ElizabethWatson, BirgitWeaver, EricWegwerth, PeterWeljie, AalimWest, ConnorWhitman, JeffreyWilliams, GraceWilliams, LeeWójcik, IwonaWong, AlanWu, LinfengXu, GangYang, EthanYates, JohnYoshida, MasaruYoussef, MohamedYun, CassandraZahoor, NeelamZhang, Jada (Yu)Zhao, LimianZhao, XuehengZhou, YuZhu, JianhuiZhu, Yu

Sunday

Sunday 800 1800

Badge Pickup @ RegDesk @ Ballroom Foyer 1346

800 1200

Short Course

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COURSE START Ending at 6PM on Sunday and Monday LC-MSMS 101 Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory Judy Stone, PhD, Deborah French, PhD & Tim Collier, PhD Level: Beginner - Intermediate @ Room 5 Group: B

Sunday 1200 1300

Lunch @ The Palmetto Restaurant 1552

1300 1800

Short Course

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Continued from Sunday AM Ending at 6PM on Sunday and Monday LC-MSMS 101 Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory Judy Stone, PhD, Deborah French, PhD & Tim Collier, PhD Level: Beginner - Intermediate @ Room 5 Group: B

Sunday 1800 2000

Poolside Dinner @ Chiki Pool 1358

Sunday 2000 2100

Hospitality Lounge @ Chiki Pool 1360

Sunday 2000 2100

Hospitality Lounge (Rain) @ The Landing 1553

Monday

Monday 700 830

Breakfast @ Gypsy Rose, Palmetto & Cantala 1361

Monday 700 1800

Badge Pickup @ RegDesk @ Ballroom Foyer 1363

730 1130

Short Course

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Continued from Sunday Cancelled Data Science 201 Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling Patrick Mathias, MD, PhD & Shannon Haymond, PhD Level: Beginner-Intermediate @ Room 1 Group: A

Continued from Sunday Cancelled LC-MSMS 202 Practical LC-MS Maintenance and Troubleshooting J. Will Thompson, PhD & Chris Shuford, PhD Level: Intermediate @ Room 3 Group: A

Continued from Sunday Metabolomics 201 Application of High Resolution Mass Spectrometry and Metabolomics in Clinical Analysis Timothy Garrett, PhD & Erin Baker, PhD Level: Intermediate @ Room 2 Group: A

Continued from Sunday Cancelled Proteomics 201 Clinical Proteomics Andy Hoofnagle, MD, PhD & Cory Bystrom, PhD Level: Intermediate - Advanced @ TBD Group: A

Monday 1130 1330

Short Course Lunch @ Cantala Restaurant 1378

1230 1630

Short Course

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Continued from Monday AM Cancelled Data Science 201 Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling Patrick Mathias, MD, PhD & Shannon Haymond, PhD Level: Beginner-Intermediate @ Room 1 Group: A

Continued from Monday AM Cancelled LC-MSMS 202 Practical LC-MS Maintenance and Troubleshooting J. Will Thompson, PhD & Chris Shuford, PhD Level: Intermediate @ Room 3 Group: A

Continued from Monday AM Metabolomics 201 Application of High Resolution Mass Spectrometry and Metabolomics in Clinical Analysis Timothy Garrett, PhD & Erin Baker, PhD Level: Intermediate @ Room 2 Group: A

Continued from Monday AM Cancelled Proteomics 201 Clinical Proteomics Andy Hoofnagle, MD, PhD & Cory Bystrom, PhD Level: Intermediate - Advanced @ TBD Group: A

Monday 1630 1900

Hospitality Lounge @ Gypsy Rose Meet up at the Gypsy Rose for a drink before heading to the dinner location of your choice. 1395

Monday 1730 1930

Dinner on Own @ YourChoice There will be food for purchase available at The Riviera Dining locations, or visit something offsite. Some places to try in walking distance: 1. Draughtsman, 3:00pm to 10pm, Food, large selection of Craft Beers, outdoor games. Settle in. 2. Sandfish, Excellent Sushi and whiskey pairings. 4:30 to 10pm. Reservation recommended. 3. Billy Reeds, American comfort food, good for large groups. 8am-9pm. 4. JJ's Latin Oasis, Mexican food, Chris Herold's favorite stop in Palm Springs since 1995. A wee bit further: 1. Copleys, Fine Dining (reservation) 2. Workshop, Contemporary (reservation) 3. Purple Palm Poolside Mediterranean (reservation) 4. Roly China Fusion 13 minute walk 5. For an adventure, dine at the top of Mt. San Jacinto after a ride on the Palm Springs Aerial Tram Have an ice cream after dinner at ICE CREAM SHOPPE open noon to 11pm. 1397

Monday 1830 2000

Private Faculty Dinner @ Chiki Pool By Invitation - Faculty including Scientific Committee members and Course Instructors as well as invited speakers and CMS Journal Editors may convene to touch base prior to the opening of the conference. 1554

Tuesday

Tuesday 700 830

Breakfast @ Gypsy Rose, Palmetto & Cantala For short course attendees with class Tuesday AM. 1400

Tuesday 700 2000

Badge Pickup @ RegDesk @ Ballroom Foyer 1401

730 1130

Short Course

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Continued from Monday PM Cancelled Data Science 201 Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling Patrick Mathias, MD, PhD & Shannon Haymond, PhD Level: Beginner-Intermediate @ Room 1 Group: A

Continued from Monday PM Cancelled LC-MSMS 202 Practical LC-MS Maintenance and Troubleshooting J. Will Thompson, PhD & Chris Shuford, PhD Level: Intermediate @ Room 3 Group: A

Continued from Monday PM Metabolomics 201 Application of High Resolution Mass Spectrometry and Metabolomics in Clinical Analysis Timothy Garrett, PhD & Erin Baker, PhD Level: Intermediate @ Room 2 Group: A

Continued from Monday PM Cancelled Proteomics 201 Clinical Proteomics Andy Hoofnagle, MD, PhD & Cory Bystrom, PhD Level: Intermediate - Advanced @ TBD Group: A

0840 1150

Get the Basics @ Rooms 4-6 Room 4 Chairs: Jen Colby and Jackie Hubbard Room 5 Chairs: David Herold and Peggi Angel An overview of the fundamentals that are driving research and development. This series of Primers on fields within Clinical Mass Spec is free to attend for ALL attendees of the MSACL Congress or Short Courses, including Partial Pass holders. Takeaways for each session include: Be able to define what the field is, why it matters, and why you personally should care. What is the clinical relevance? Understand what role mass spectrometry plays in this field. Where does mass spec fit in to the big picture of the field? Define any terminology that is specific to this field. Describe how it works, what are the methods and workflows used when studying this field and/or how is it implemented in clinical labs. Identify any challenges to implementation/adoption, where do the opportunities lie? 08:40 - 09:20 Room 4: Metabolomics with Adam Rosebrock Room 5: Proteomics with Tim Collier 09:30 - 10:10 Room 4: Lipidomics with Anne Bendt Room 5: Glycomics with Richard Drake 10:20 - 11:00 Room 4: Toxicology with Paul Jannetto Room 5: Imaging Mass Spectrometry with Ron Heeren 11:10 - 11:50 Room 4: Sample Preparation with Mark Marzinke Room 5: Data Science with Alfonso Limon

Tuesday 11:50 1400

Lunch on your own @ YourChoice Join a Workshop, where a Sandwich Lunch will be served. Alternatively, enjoy lunch onsite at one of the Riviera dining spots, or offsite with fellow attendees. If you would like to head offsite: 1. Wexler's Deli 2. Billy Reeds, American comfort food, good for large groups. 8am-9pm. 3. JJ's Latin Oasis, Mexican food 4. Roly China Fusion, 13 minute walk 5. Trio One mile away, 20 minute walk. 6. Cheekys Popular for Brunch and Bacon Flights. One mile away, 20 minute walk. 7. Mid Mod Cafe, for the health conscious, 3 minute drive 8. Tac/Quila, elevated Mexican Cuisine, 3 minute drive 1623

Tuesday 1100 1600

Place Wed Posters @ Exhibit Hall 1555

1215 1345

Lunch Vendor Workshop(s)

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Indigo BioAutomation @ Rm 1-3 Pre-Register Let the Data Speak. Data Driven Decision Making for Mass Spectrometry. Moderator: Randall Julian, Ph.D., CEO and Founder, Indigo BioAutomation Speakers: Romeo Solano, Ph.D., F-ABFT, Senior Scientific Director, Quest Diagnostics Why do staff migrate to certain instruments when they need to report results within a defined turn-around time? Is everyone following your SOPs? Big data analysis can provide insights into operational transformation of processes in every laboratory, show how instruments and staff members are performing, and guide root cause analysis to drive actionable solutions. Using Tableau to analyze ASCENT flags and decisions with respect to Calibrators, QCs, and Unknowns, this presentation will demonstrate how effective changes to LC-MS/MS procedures can benefit process and reduce data review time. Will Slade, Ph.D., Systems Scientist, Indigo BioAutomation Data review in high-throughput settings traditionally involves monotonous evaluation of every chromatogram, making review into an art as much as a science. This risks a confidence coming from manually inspecting a plot instead of trusting established metrics. Using ASCENT and R statistical programming language, this presentation will describe Indigo’s journey into the largely unexplored wealth of big data already being collected, what we have learned, and where we want to go.

Tuesday 1400 1415

Welcome Orientation @ Rooms 4-6 1424

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1415	Opening Plenary Lecture @ Rooms 4-6 Chair: Livia Eberlin

1415 1500		Comprehensive Mapping of Cell Lineage and Function in Human Tissue Using MIBI-TOF Michael Angelo Stanford Bio-X Michael Angelo is an assistant professor in the Department of Pathology at Stanford University. He is board certified in clinical pathology and a recipient of the NIH Director’s Early Independence Award. Dr. Angelo received a BS in Physics from the University of Mississippi in 2002 and subsequently enrolled at Duke University, where he received an MD and PhD in Electrical and Computer Engineering in 2010. He trained in clinical pathology at UCSF and completed a postdoctoral research fellowship in the lab of Garry Nolan. His main research focus is creating and applying next generation instrumentation and methods for nanometer scale, multiplexed, quantitative imaging of genes and proteins in clinical tissue biopsies. With this in mind, his lab has developed a purpose-built instrument that utilizes high brightness primary ion sources and orthogonal time-of-flight mass spectrometry to rapidly image antibodies tagged with elemental metal reporters in intact tissue sections at sub-cellular resolution. Multiplexed ion beam imaging by time of flight (MIBI-TOF) permits simultaneous, rapid, and quantitative imaging of up to 42 metal-labeled antibodies at resolutions down to 250nm. This technology is being utilized in Dr. Angelo’s lab to characterize the phenotype and spatial organization of infiltrating immune cells in breast carcinoma, lung carcinoma, and melanoma. In addition to immune oncology, MIBI-TOF is being utilized to study immune tolerance in granulomatous inflammation, at the maternal fetal interface, and in solid organ transplantation.

Tuesday 1500 1515

Intermission @ Ballroom Foyer 1426

1515 1600

State of the Science Address @ Rooms 4-6

Chairs: Cory Bystrom and Dan Holmes Speakers: Patrick Mathias, Adam Rosebrock, Chris Cox, Grace van der Gugten, Chris Shuford, Peggi Angel, Jennifer Colby Presented by MSACL US Scientific Committee Topic Leads, this address will provide an overview of the applications and technologies currently being used in Clinical Labs, and a clear view of the development pipeline. It will highlight applications expected to be available in the near-future, as well as emerging applications, and key contributors. Relevant talks, posters, and people present at the congress will be identified, enabling you to optimize your learning path and more effectively target potential network connections. Whether you are new to Clinical Mass Spectrometry, or a seasoned veteran, the State of the Science address should be on your agenda.

Tuesday 1600 1615

Intermission @ Ballroom Foyer 1428

Tuesday 1615 1645

Poster Lightning Talks @ Rooms 4-6 Chair: Cory Bystrom Poster Contest semi-finalists will highlight their work in 90 seconds, and one slide. 1429

Tuesday 1645 1715

Vendor Lightning Talks @ Rooms 4-6 Chair: Chris Herold An opportunity to discover vendors and learn what's new. Up to 20 vendors will be highlighted, each given 90 seconds and one slide. 1430

Tuesday 1715 2000

Exhibits Opening @ Exhibit Hall 1431

Tuesday 1800 1900

Meet-a-Mentor: Booth Tours @ Exhibit Hall Join a mentor as they tour the booths and learn more about technologies available, what mentors are looking for during the exchange, and how they interact with the booth vendors. Increase your network and your knowledge of products and services available. 1434

1900 2000

Troubleshooting Forum: Poster Rounds @ Exhibit Hall Join the troubleshooting poster discussion to learn something new or add your two cents.

19:00 @ poster #93a “Continental Drift” and Varying Vitamin D Results Dependent Upon Methanol Reagent Lot Joshua Akin UC San Diego Health

19:15 @ poster #94a Recovery of Insulin-like Growth Factor 1 (IGF-1) Signature Peptides Amol Bajaj ARUP Laboratories

19:30 @ poster #95a Steroid Assay Development Nightmare – Analytes in Every Sample and Everywhere Katerina Sadilkova Seattle Children’s Hospital

19:45 @ poster #96a Distinguishing Contamination from Carryover When Using LC-MS/MS to Detect Drugs of Abuse Kristine van Natta Thermo Fisher Scientific

2000 2100

Discussion Group: CDC Clinical Standardization Programs Forum @ Room 1 Chair: Hubert Vesper Overview of ongoing and new CDC’s Standardization Programs

2000 2100

Discussion Group: From the Operating Room to the Mass Spec: Handling and Storage of Human Tissue Samples @ Room 2 Chair: Chris Anderton Hosted by IMSS. We will discuss patient-specific effects, sample collection, transport and handling of samples, and tissue preparation when acquiring and interpreting mass spectrometry data. We will especially focus on how these steps effect imaging mass spectrometry data, but many of these topics translate universally across mass spectrometry approaches in general. This will be an open forum with predefined topics to guide the conversation.

2000 2100

Discussion Group: R/Medicine - Integrating R into Clinical Practice @ Room 3 Hosted by R/Medicine and moderated by Stephan Kadauke. Speakers: Stephan Kadauke, Michael Kane, Joseph Rickert R is a free programming language and a powerful statistical computing environment that is wildly popular among statisticians and data scientists. R is ideally suited for building customized applications for clinical operations, however many (real and perceived) hurdles exist in operationalizing R in healthcare in general, and in the labs in particular. The speakers are the organizers of R/Medicine, an annual conference that aims to promote the R ecosystem in clinical research and practice. This will be a highly interactive session aimed to share insights and experiences both of the discussants and participants, with the aim of facilitating the integration of the R ecosystem into clinical laboratory practice. Learning objectives: After completing this activity, participants will be able to: 1. Cite resources available for R and data science education tailored for clinicians and laboratorians. 2. Describe organizational, regulatory, and cultural challenges to integrating the R ecosystem into clinical practice. 3. Discuss best practices for building customized clinical laboratory-developed applications (“lab apps”) in R/Shiny. Speakers: Stephan Kadauke, Assistant Professor of Pathology and Laboratory Medicine at the Children’s Hospital of Philadelphia Michael Kane, Assistant Professor of Biostatistics at Yale University, past Chair of R/Medicine Joseph Rickert, RStudio PBC, and the R Consortium

2000 2100

Discussion Group: Clinical Cases – Where Mass Spec made a Difference in Patient Care @ Room 4 Hosted by AACC and moderated by Carmen Wiley. Speakers: Nicole Tolan, Dennis Dietzen, and Stephen Master Mass spectrometry continues to play a prominent role in the field of laboratory medicine. In this session, each speaker will highlight a clinical case where Mass Spec Analysis has made all the difference in a patient's care and outcome. Learning objectives: After completing this activity, the learner will be able to: 1. site examples where mass spectrometry made a difference in patient care 2. describe how mass spectrometry could play an important in their institutions 3. summarize the role of mass spectrometry played in each of these case studies Speakers: Nicole Tolan, Assistant Professor of Pathology at Harvard Medical School Dennis Dietzen, Professor, Pathology & Immunology at Washington University School of Medicine Stephen Master, Associate Professor of Pathology and Laboratory Medicine at the Children's Hospital of Philadelphia

2000 2100

Discussion Group: Developing Mass Spectrometric Assays for Obesity and Diabetes Clinical Research @ Room 6 Moderator: Salvatore Sechi, NIDDK/NIH Presenters/Discussants include: Jenny Van Eyk (Cedars Sinai); Wei-Jun Qian (PNNL); Andy Hoofnagle (University of Washington) The NIDDK recently started a program for developing mass spectrometric assays for proteins and peptides of primary interest to the obesity and diabetes research community. These assays should be highly reproducible, easily transferable to other laboratories, and validated in human plasma or serum. Examples, of proteins and peptides that are of potential interest include insulin, glucagon, c-pepitide, glycated CD59, Adiponectin, Leptin, Resistin, Neuropeptide Y, Alpha-melanocyte-stimulating hormone, Peptide YY, Glucagon-like peptide 1, Ghrelin, Adrenocorticotropin, Corticotropin-releasing hormone, Gastrin, Cholecystokinin, Secretin, Vasoactive intestinal peptide, gastric-inhibitory peptide, gastrin-releasing peptide, motilin, pancreatic polypeptide, RBP4, myostatin, FGF21). We will discuss how we might proceed in developing, validating, and implementing MS assays of interested to the Obesity and Diabetes community.

Tuesday 2000 2200

Hospitality Lounge @ Soleil Pool 1438

Wednesday

Wednesday 700 1800

Badge Pickup @ RegDesk @ Ballroom Foyer 1441

800 845

Corporate Workshop(s)

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Biotage @ Rm1 Pre-Register One Size Does Not Fit All: Considerations for Minimizing Matrix Effect and Maximizing Recovery for Clinical Panels Large and Small Dr. Lee Williams. Biotage GB Limited, Distribution Way, Dyffryn Business Park, Hengoed, CF82 7TS, UK. LC-MS/MS system sensitivity has moved at an alarming rate over the last 10 years. The original perception that due to increased instrument sensitivity sample preparation will decrease has been dispelled. This sensitivity can come at a price, in that levels of contamination not previously detected with less sensitive instruments now have larger impact on analysis. Combining this with the advent of UHPLC, the necessity for high purity components and samples is even more apparent. Given this information the choice of sample preparation technique varies between labs and is generally dependent on several factors: operator familiarity; technique complexity; price per sample; instrument sensitivity; assay sensitivity and limits of quantitation; sample volume; throughput; analyte functionality and target matrix. Typical clinical matrices include whole blood, plasma, serum, urine and oral fluid with specific emphasis on a variety of endogenous components. Matrix complexity will be illustrated and related to a variety of clinical assays, demonstrating potential impact on method robustness. Examples will detail challenges involved for large panel analysis.

Thermo Fisher Scientific @ Rm2 LC-MS/MS Developments for the Routine Clinical Lab Overview: Accurate analyte measurements are important for assessment and management of patients. LC-MS/MS measurement procedures are more selective than immunoassay measurement procedures. However, increased labor for preanalytical processing, method validation for LDTs, in conjunction with lack of complete automation of quality assurance monitoring, have presented barriers to LC-MS/MS implementation. This workshop will provide the opportunity to discuss the quality assurance needs of the routine clinical laboratory, the challenges associated with managing laboratory developed tests (LDTs) and the perspectives on future LC-MS/MS developments. *Product is not 510(k) cleared and is not yet available for sale in the U.S.

MilliporeSigma @ Rm3 How is the emergence of hemp affecting the Clinical space? Synthesis, certification and clinical evaluation of 7-Hydroxy and 7-Carboxy Cannabidiol Certified Reference Materials in whole blood samples by LC-MS/MS Speakers: Heather Lima - Principal Scientist, Synthesis, Cerilliant Corporation, Ray Suhandynata – Clinical Chemistry Fellow, University of California-San Diego Center for Advanced Laboratory Medicine Cannabidiol (CBD), a non-psychoactive constituent of hemp, has been increasingly promoted and studied for pharmacological uses as regulations regarding cannabis and hemp evolve rapidly at a state and federal level. In response to these recent regulations, novel Cannabinoid Certified Reference Materials (CRMs) and testing methods have been developed for the main human metabolites of CBD, 7-hydroxy cannabidiol (7-OH CBD) and 7-carboxy cannabidiol (7-COOH CBD). We will touch on recent legal changes for cannabinoid testing in a Clinical setting, as well as discuss the synthesis, certification, and evaluation of these cannabinoid CRMs in patient whole blood samples at the Center for Advanced Laboratory Medicine at UCSD.

SCIEX @ Rm4 Pre-Register Acoustic Ejection Mass Spectrometry (AEMS) for High-throughput Analysis Chang Liu, Associate Staff Research Scientist, SCIEX Learn about the newly designed, novel mass spectrometry (MS) platform with integrated acoustic droplet ejection (ADE) technology. The open-port interface (OPI) paired with electrospray ionization (ESI) MS utilizes nanoliter droplets in a touchless manner to deliver high speed, precision and accuracy. The sample dilution within the OPI in concert with the capabilities of modern ESI-MS minimizes assay development. The combination, almost eliminates the laborious sample preparation required for both clean and dirty matrices such as plasma and urine, and results in no observed carry-over. See how second-per-sample analysis speed can be routinely achieved with high sensitivity, high reproducibility, wide linear dynamic range, and broad compound coverage.

Agilent Technologies @ Rm5 Pre-Register Reducing the Steps from Sample Submission to Reporting Implementing a Walk-Up sample submission process with automated data processing reduces the training, labor and time required to analyze clinical diagnostic samples.   For In Vitro Diagnostic Use

Indigo BioAutomation @ Rm6 Pre-Register Elevating your lab further. Speakers: Jim Edwards and Adam Zabell, Ph.D. We’ve been helping labs elevate their business performance and technical efficiency with a simple vision: better science to generate better results. Those results are based on great data, effective models and comprehensive quality awareness, but moving beyond the batch requires a better toolbox so people at every level of the laboratory can integrate their effort into enhancing the entire business. Our latest innovations have come together in ASCENT Series 4, streamlining batch review and adding the features you need to identify not just if but when and why your assay is meeting your expectations. Please join us for an introduction to a better way to work, whether that means migrating from your incumbent software or upgrading your current ASCENT platform. We’ve brought together the best discoveries based on what we’ve learned working side-by-side with laboratories like yours, all in service of the tools that make for better science.

Wednesday 845 900

Intermission @ Ballroom Foyer 1455

Scientific Session 1

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	Track 1 Room 1 Tox/TDM/Endocrine: Order of Operations: Workflow Optimization and Quality Improvements for Mass Spectrometry Chair: Stephen Roper 2nd Chair: Scott Borden	Track 2 Room 2 Standardization and Normalization of Metabolomic and Lipidomic Workflows Chair: Melanie Odenkirk	Track 3 Room 3 Data Science Keynote: Olga Vitek Chair: Randall Julian	Track 4 Room 4 Imaging MS: In the Clinic Chair: Peggi Angel 2nd Chair: Anna Krieger	Track 5 Room 5 Proteomics: Innovating New Biomarkers Chair: Stephen Pennington	Track 6 Room 6 Practical Training Chair: Hema Ketha 2nd Chair: Deborah French
900 920	TBA	TBA	TBA	TBA	TBA	TBA
920 940	TBA	TBA	TBA	TBA	TBA	TBA
940 1000	TBA	TBA	TBA	TBA	TBA	TBA

Wednesday 1000 1100

Exhibits & Poster Session @ Exhibit Hall Even 'a' poster positions to be attended. 1462

Scientific Session 2

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	Track 1 Room 1 Not Your Average Cannabinoids Chair: Jen Colby 2nd Chair: Chris Koch	Track 2 Room 2 Beyond Metabolomics -or- Lipidomics: Mutli-omic Analysis of Patient Samples Chair: Elizabeth Want	Track 3 Room 3 Data Flow Chair: Will Slade	Track 4 Room 4 Imaging MS Keynote: Lingjun Li Chair: Richard Drake	Track 5 Room 5 Proteomics: Clinical Biomarker Assays - Revamped Chair: Chris Shuford	Track 6 Room 6 Practical Training Chair: Elizabeth Frank 2nd Chair: Jacqueline Hubbard (pending)
1100 1120	TBA	TBA	TBA	TBA	TBA	TBA
1120 1140	TBA	TBA	TBA	TBA	TBA	TBA
1140 1200	TBA	TBA	TBA	TBA	TBA	TBA

Wednesday 1200 1400

Lunch On Own @ YourChoice Maximize learning opportunities by popping into a Workshop where a sandwich lunch will be served, or enjoy a meal at one of The Riviera dining options, or take a walk to a nearby option such as Wexler's or Rick's Desert Grill. 1471

1230 1330

Corporate Workshop(s)

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Shimadzu @ Rm1 Developing a Comprehensive Mass Spectrometry Program at an Academic Medicine Center Chris Crutchfield, PhD, HCLD(ABB), DABCC, Assistant Professor, University of Cincinnati College of Medicine, Department of Pathology & Laboratory Medicine The advent of early career clinical scientists trained in mass spectrometry has arrived. A practical challenge for those clinical scientists entering their first jobs at academic medical centers will be how to navigate the assembly or the expansion of clinical mass spectrometry within the laboratory, as well as how to balance the needs of meeting expectations for both routine clinical work and academic research. This workshop will include a series of vignettes developed in the context of expanding mass spectrometry at an academic medical center: • Partnering with a business director to develop a business rationale to justify acquisition of two mass spectrometers to expand immunosuppressant monitoring • Joining a research team as a co-PI, receiving a perfect score on an NIH U01 grant, “IND-Enabling Pre-Clinical Studies to Accelerate the Clinical Development of a Humanized Anti-Cocaine Monoclonal Antibody,” and including a mass spectrometer in the approved budget • Pearls of Wisdom for training medical technologists and research technicians clinical mass spectrometry assay preparation and method development

Thermo Fisher Scientific @ Rm2 Paper Spray Mass Spectrometry (PS-MS) for Direct, Quantitative Measurements Professor Chris G. Gill, Ph.D., P. Chem., Co-Director, Applied Environmental Research Laboratories, Vancouver Island University, Nanaimo, BC, Canada Paper spray ionization for mass spectrometry is a relatively new, simple, and inexpensive strategy for ambient ionization. Analytes are ionized for mass spectrometry directly from small volumes of complex samples deposited on pointed paper strips, in a mechanism akin to electrospray. It is particularly useful where rapid, direct quantitative chemical measurements are needed. We present PS-MS in select applications: direct drug analysis in urine, and onsite illicit drug checks for harm reduction in the opioid overdose crisis. Lipidomics Analysis of Barth Syndrome Patients Seul Kee Byeon1, Devin Oglesbee1, and Akhilesh Pandey1,2, 1Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester MN 55905, 2Center for Individualized Medicine, Mayo Clinic, Rochester MN Barth syndrome (BTHS) is a rare X-linked recessive disorder that presents with infantile cardio- and skeletal myopathy, neutropenia, and growth delays. We hypothesized rare subtypes of various classes of lipids may contribute to BTHS. We characterized various classes of lipids and discovered lipid profiles associated with BTHS. Our studies show that unique lipid signatures can differentiate BTHS patients from controls.

Bruker @ Rm4 Pre-Register Bruker will be presenting two talks during our workshop: PASER: Parallel Database Search Engine I Real-Time John R. Yates III Ernest W. Hahn Professor in the Departments of Molecular Medicine and Neurobiology at The Scripps Research Institute Clinical Implementation of Mass Spectrometry Imaging Sankha (Bobby) Basu, MD, PhD Assistant Director of Clinical Chemistry and Mass Spectrometry and Instructor of Pathology at Harvard Medical School To view both abstracts please click on the registration link. For Research Use Only. Not for use in diagnostic procedures.

Agilent Technologies @ Rm5 Pre-Register Agilent will be presenting two talks during the lunch seminar: QA/QC of Large-Scale and High-Coverage Mass Spectrometry-based Lipidomics Analyses Bo Burla Ph.D. National University of Singapore Detection of Chemical Weapon Nerve Agents in Bone Timothy J. Garrett, PhD University of Florida For Research Use Only. Not for use in diagnostic procedures.

1230 1330

Discussion Group: METASPACE @ Room 3 Chair: Theodore Alexandrov A workshop to discuss METASPACE. The METASPACE platform hosts an engine for metabolite annotation of imaging mass spectrometry data as well as a spatial metabolite knowledgebase of the metabolites from hundreds of public datasets provided by the community.

Scientific Session 3

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	Track 1 Room 1 Fentanyl at the Forefront: Using Non-traditional Approaches to Identify Fentanyl Analogs Chair: Hema Ketha 2nd Chair: Melissa Hoffman	Track 2 Room 2 Imaging -omics of Hepatic Disease Chair: Michael Chen	Track 3 Room 3 Microbiology Keynote: Robert Cody Chair: Chris Cox	Track 4 Room 4 Imaging MS: Translational Research Chair: Reid Groseclose 2nd Chair: Aalim Weljie	Track 5 Room 5 Proteomics: Established Biomarkers Done Better Chair: Andrew Hoofnagle	Track 6 Room 6 Practical Training Chair: Grace van der Gugten
1400 1420	TBA	TBA	TBA	TBA	TBA	TBA
1420 1440	TBA	TBA	TBA	TBA	TBA	TBA
1440 1500	TBA	TBA	TBA	TBA	TBA	TBA

Wednesday 1500 1615

Exhibits & Poster Session @ Exhibit Hall Odd 'a' poster positions to be attended. 1479

Wednesday 1515 1600

Meet-a-Mentor: Poster Tours 1 @ Exhibit Hall Join a mentor as they tour the posters. Learn more about what mentors are looking for in a poster, and how they engage the presenter. 1480

Wednesday 1600 1615

Remove Wed Posters @ Exhibit Hall 1574

Scientific Session 4

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	Track 1 Room 1 A 360ᵒ View of Immunosuppressants: Assay Development to Clinical Applications Chair: Mark Marzinke 2nd Chair: Ganesh Moorthy	Track 2 Room 2 Metabolomics of Small Volume Specimens - Doing More with DBS Chair: Amy Caudy (pending)	Track 3 Room 3 Data Science Keynote: Andrea Geistanger Chair: Stephen Master	Track 4 Room 4 Imaging MS: Biomarkers Chair: Kevin Schey 2nd Chair: Marissa Jones	Track 5 Room 5 Pinky and the Brain Proteomics Chair: Tim Collier	Track 6 Room 6 Practical Training Chair: Matt Crawford 2nd Chair: Deborah French
1615 1635	TBA	TBA	TBA	TBA	TBA	TBA
1635 1655	TBA	TBA	TBA	TBA	TBA	TBA
1655 1715	TBA	TBA	TBA	TBA	TBA	TBA

Wednesday 1715 1830

Exhibits @ Exhibit Hall 1487

Wednesday 1715 1730

Place Thu Posters @ Exhibit Hall 1575

Wednesday 1730 1830

Meet-a-Mentor: Office Hours @ Exhibit Hall Have a question from the congress that you have been itching to ask? Or a problem from work that you want to get feedback on? Or feedback on the congress? Sign up at the registration desk for 15-min blocks to share time and ideas with a mentor in a relaxed setting. View Mentors and more info. 1488

1730 1830

Troubleshooting Forum: Poster Rounds @ Exhibit Hall Join the troubleshooting poster discussion to learn something new or add your two cents.

17:30 @ poster #93b Understanding and Managing Matrix and Solvent Instability for Olanzapine Diane Ly ARUP Laboratories

17:45 @ poster #94b Investigation of Range Independent Deviations at High End of the Curve Koen van der Drift Darthmouth-Hitchcock Medical Center

18:00 @ poster #95b Seeing the Invisible; Ion Suppression Resulting from Discrete Pharmaceuticals and Metabolites Anna Miller MedTox, Labcorp

18:15 @ poster #96b Nonspecific Adsorption and Loss of 11-nor-9-carboxy-Δ9-tetrahydrocannabinol. Dude, Where’s My THC? Triniti Jensen ARUP Laboratory

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1845	Distinguished Contribution Award Plenary Lecture @ Rooms 4-6 Chair: Distinguished Contribution Award Committee : Shannon Haymond, Marilyn Huestis, Rick Yost, Stephen Master

1845 1930	On the Award	My Path to Enlightenment, or How I Became a Clinical Mass Spectrometrist and Clinical Chemist Alan Rockwood Professor Emeritus, University of Utah Alan Rockwood, PhD, DABCC is Professor (Clinical) Emeritus of Pathology at the University of Utah School of Medicine in Salt Lake City, Utah, USA. Originally trained in Physical Chemistry, he performed research on the fundamentals of mass spectrometry and instrumentation development before focusing his career on Clinical Chemistry. He is certified by the American Board of Clinical Chemistry and has held a Certificate of Qualification in Clinical Chemistry from the New York State Board of Health. Currently, his primary area of research is the development of mass spectrometry-based quantitative assays for targeted analytes of clinical interest, including small molecules and more recently proteins and peptides. Additionally, he maintains a smaller research effort on fundamentals of mass spectrometry, particularly novel approaches for isotopic profile calculations. He has published >150 papers in peer reviewed journals.

1945 2045

FeMS: Award Presentation and Discussion Group @ Room 1 Chairs: Grace van der Gugten and Hema Ketha 1. Presentation of The Catherine E Costello Award for Females in Mass Spectrometry to Dr. Sarah Brown Riley, sponsored by Avanti Polar Lipids and presented by Catherine E Costello. 2. Small group networking and guided discussion regarding topics relevant to Females in Mass Spectrometry.

Wednesday 1945 2200

No Host Dinner @ Soleil Pool Enjoy a pleasant Palm Springs evening with colleagues by the pool where food and drinks will be available for purchase. Alternatively, if you prefer an offsite meal, you can try nearby: 1. Draughtsman, 3:00pm to 10pm, Food, large selection of Craft Beers, outdoor games. Settle in. 2. Sandfish, Excellent Sushi and whiskey pairings. 4:30 to 10pm. Reservation recommended. 3. Billy Reeds, American comfort food, good for large groups. 8am-9pm. 4. JJ's Latin Oasis, Mexican food. A wee bit further: 1. Copleys, Fine Dining (reservation) 2. Workshop, Contemporary (reservation) 3. Purple Palm Poolside Mediterranean (reservation) 1492

Thursday

800 845

Corporate Workshop(s)

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PerkinElmer @ Rm1 Achieving the Standard for the Analytical Scope and Sensitivity Testing in Impaired Driving using Laminar Flow Tandem Mass Spectrometry Sabra Botch-Jones, M.S., M.A., D-ABFT-FT Assistant Professor, Department of Anatomy & Neurobiology Boston University School of Medicine Based on results from the 2017 National Survey on Drug Use and Health, 21.4 million people aged 16 or older operated a vehicle under the influence of alcohol and 12.8 million drove under the influence of illicit drugs in the previous year. Due to the prevalence of driving while impaired, the forensic toxicology scientific community developed ASB Standard 119 “Standard for the Analytical Scope and Sensitivity of Forensic Toxicology Testing in Impaired Driving Investigations”. The scope of the standard provides the minimum requirement for target analytes and analytical sensitivity for the analysis biological fluids such as urine in suspected drugged driving cases.

Chromsystems @ Rm2 Validation and Implementation of the Chromsystems MassTox Drugs of Abuse Assay on a High Resolution Accurate Mass Spectrometer Speaker: Dr Sergei Likhodi, Scientific Director, BC Provincial Toxicology Centre, Provincial Health Services Authority, Vancouver, BC, Canada Dr Likhodi will discuss the experience of his laboratory in implementing the MassTox® Drugs of Abuse Testing assay, a commercial solution that allows the target screening of 108 drugs. He will show validation and performance data, but will also explain how his laboratory successfully expanded the assay with additional drugs analyzed by the same method. Dr Likhodi will demonstrate that the assay, originally developed for LC-MS/MS, can be also established on high resolution mass spectrometers for routine analysis.

Newomics @ Rm3 Multiply Mass Spectrometry Performance with Multinozzle Emitter Technology Na Parra, Ph.D., Senior Director of Marketing, Newomics, Berkeley, CA Nanoflow LC-MS enables high sensitivity analysis of proteins and lipids in biological samples. However, it lacks robustness and throughput. High-flow LC-MS achieves robustness but its sensitivity needs improvement. Microflow LC-MS bridges this gap with a balance of sensitivity and robustness. Newomics award-winning silicon-multinozzl-emitter splits a microflow stream into multiple nanoflows to dramatically enhance ionization efficiency and achieve high sensitivity, robustness, and throughput. The applications of our microflow-LC-nanospray-ESI-MS-platform using Newomics M3 emitter has been demonstrated in proteomics, lipidomics, and native MS. New Highly Sensitive and Specific Top-Down Mass Spectrometric CDC Reference Procedure for Parathyroid Hormone Candice Ulmer, Ph.D., Associate Service Fellow, CDC, Atlanta, GA Parathyroid hormone (PTH) is a key biomarker for chronic-kidney-disease. Measurement of PTH and fragments in serum is critical for disease diagnosis. PTH is at low circulating levels. Current methods show high variability. Thus, a highly sensitive and reliable reference procedure is in need for analysis of PTH and fragments. A top-down proteomics UHPLC-HRMS reference procedure was developed using a Thermo-Q-Exactive-Plus, an UltiMate-3000-RSLCnano, and Newomics M3 emitter. This method allows for serum iPTH measurements from CKD patients.

Waters @ Rm4 Pre-Register ‘Sensitivity, Selectivity, and Speed’ - Solving Analytical Challenges in Endocrinology using LC-MS/MS for Clinical Research Presenter: Dominic Foley, Senior Scientist, Waters Corporation, Wilmslow, UK The use of LC-MS/MS technologies in Endocrinology for clinical research is an area of rapid growth. This is a result of the demonstrated improvements in selectivity provided by the platform compared to more traditional technologies such as immunoassay. In addition, the ability to monitor large number of analytes in a single method, with improvement in both analytical sensitivity and selectivity, increases the speed at which a sample can be interrogated for biochemical abnormalites. In this workshop, we will cover aspects of analytical sensitivity, selectivity and speed in relation to improving the performance of endocrine methods using higher end LC-MS/MS platforms such as the Xevo TQ-S micro and Xevo TQ-XS mass spectrometers.

Restek @ Rm5 Coated Blade Spray Mass Spectrometry redefines rapid screening and quantitation of small molecules in biological fluids Presented by Kara Lynch, PhD; Associate Professor, University of California San Francisco German Gomez, PhD; R&D Scientist, Restek Corporation Current workflows for the determination of controlled substances and drugs of abuse in biological fluids rely on sometimes lengthy and complex sample preparations and chromatographic separations. This is particularly challenging in cases where obtaining reliable results rapidly is of prime importance. Undeniably, there is need for highly robust and trustworthy devices that enable rapid detection and quantitation of drugs of abuse in biological fluids, particularly on-site. Coated Blade Spray (CBS) is a technology that combines sample preparation and direct coupling to mass spectrometry (MS) on a single device. Dr. Gomez will briefly introduce the fundamentals behind CBS-MS and Dr. Lynch will describe the challenges clinical researchers experience when performing rapid screening and how CBS-MS can be used as a tool to overcome some of these challenges.

Thursday 845 900

Intermission @ Ballroom Foyer 1504

Scientific Session 5

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	Track 1 Room 1 Targeted Mass Spectrometric Applications for Targeted Populations Chair: Richard Van Breemen 2nd Chair: Ruben Luo	Track 2 Room 2 Discovery Metabolomics of Clinical Cohorts Chair: Amy Caudy (pending)	Track 3 Room 3 Data Science: Toxicology Chair: Lindsay Bazydlo	Track 4 Room 4 Microbiology: New and Experimental Approaches in Microbial Mass Spectrometry Chair: Chris Cox	Track 5 Room 5 Proteomics Keynote: Michael Lassman Chair: Mari DeMarco	Track 6 Room 6 Practical Training Chair: Will Thompson 2nd Chair: Judy Stone
900 920	TBA	TBA	TBA	TBA	TBA	TBA
920 940	TBA	TBA	TBA	TBA	TBA	TBA
940 1000	TBA	TBA	TBA	TBA	TBA	TBA

Thursday 1000 1100

Exhibits & Poster Session @ Exhibit Hall Even 'b' poster positions to be attended. 1512

Thursday 1015 1100

Meet-a-Mentor: Poster Tours 2 @ Exhibit Hall Join a mentor as they tour the posters. 1514

Scientific Session 6

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	Track 1 Room 1 Tox/TDM/Endocrine Keynote: Thomas Rosano Chair: Jen Colby	Track 2 Room 2 Glycomics Chair: Richard Drake	Track 3 Room 3 Microbiology Werkshop Chair: Chris Cox	Track 4 Room 4 Imaging MS: Therapeutic Targets Chair: David Muddiman	Track 5 Room 5 Omics Data Science Chair: Irene van den Broek	Track 6 Room 6 Practical Training Chair: Zlata Clark 2nd Chair: Jacqueline Hubbard (pending)
1100 1120	TBA	TBA	TBA	TBA	TBA	TBA
1120 1140	TBA	TBA	TBA	TBA	TBA	TBA
1140 1200	TBA	TBA	TBA	TBA	TBA	TBA

Thursday 1200 1315

Lunch @ Exhibit Hall 1521

Scientific Session 7

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	Track 1 Room 1 TBA Chair: TBA	Track 2 Room 2 Metabolomics Keynote: Theodore Alexandrov Chair: Adam Rosebrock (pending)	Track 3 Room 3 TBA Chair: TBA	Track 4 Room 4 New Imaging Hardware/Technology Chair: Christopher Anderton 2nd Chair: Wojciech Michno	Track 5 Room 5 Monoclonal Ab Therapeutics and MS Chair: Paula Ladwig	Track 6 Room 6 Practical Training Chair: Russ Grant 2nd Chair: Grace van der Gugten
1315 1335	CLOSED	TBA	CLOSED	TBA	TBA	TBA
1335 1355	CLOSED	TBA	CLOSED	TBA	TBA	TBA
1355 1415	CLOSED	TBA	CLOSED	TBA	TBA	TBA

1315 1415

Exhibitor Feedback Meeting @ Room 1 Chair: Chris Herold Exhibitors, please have at least one representative attend this important opportunity to shape the future editions of MSACL.

Thursday 1415 1530

Exhibits & Poster Session @ Exhibit Hall Odd 'b' poster positions to be attended. Poster Finalists to attend their posters for final interviews. 1528

Thursday 1515 1530

Remove Posters @ Exhibit Hall You can store your poster at the Reg Desk until 20:00. 1530

Thursday 1530

Exhibits Closed @ Exhibit Hall 1532

Scientific Session 8

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	Track 1 Room 1 Practical Training Chair: Shannon Haymond 2nd Chair: Judy Stone	Track 2 Room 2 New Applications and Strategies Chair: Livia Eberlin 2nd Chair: Anand Mehta	Track 3 Room 3 Closed Chair: TBA	Track 4 Room 4 Keynote: Catherine Costello Chair: David Muddiman	Track 5 Room 5 Closed Chair: TBA	Track 6 Room 6 Closed Chair: TBA
1530 1550	TBA	TBA	CLOSED	TBA	CLOSED	CLOSED
1550 1610	TBA	TBA	CLOSED	TBA	CLOSED	CLOSED
1610 1630	TBA	TBA	CLOSED	TBA	CLOSED	CLOSED

Thursday 1630 1645

Plenary Reception @ Ballroom Foyer 1531

Thursday 1645 1700

Poster Awards @ Rooms 4-6 Chair: Cory Bystrom Join us in congratulating the winners of the poster contest. 1536

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1700	Plenary Lecture @ Rooms 4-6 Chair: David Herold

1700 1745		Brain Organoids as a Model System for Human Neurodevelopment and Evolution Alysson Muotri University of California, San Diego Dr. Muotri earned a BSc in Biological Sciences from the State University of Campinas in 1995 and a Ph.D. in Genetics in 2001 from University of Sao Paulo, in Brazil. He moved to the Salk Institute as Pew Latin America Fellow in 2002 for a postdoctoral training in the fields of neuroscience and stem cell biology. He has been a Professor at the School of Medicine, University of California in San Diego since late 2008. His research focuses on modeling neurological diseases, such as Autism Spectrum Disorders, using human induced pluripotent stem cells and brain organoids. He has received several awards, including the prestigious NIH Director’s New Innovator Award, NARSAD, Rock Star of Innovation from CONNECT, NIH EUREKA Award among others. Structural and transcriptional changes during early brain maturation follow fixed developmental programs defined by genetics. However, whether this is true for functional network activity remains unknown, primarily due to experimental inaccessibility of the initial stages of the living human brain. We developed cortical organoids that spontaneously display periodic and regular oscillatory network events that are dependent on glutamatergic and GABAergic signaling. These nested oscillations exhibit cross-frequency coupling, proposed to coordinate neuronal computation and communication. As evidence of potential network maturation, oscillatory activity subsequently transitioned to more spatiotemporally irregular patterns, capturing features observed in preterm human electroencephalography (EEG). These results show that the development of structured network activity in the human neocortex may follow stable genetic programming, even in the absence of external or subcortical inputs. Our approach provides novel opportunities for investigating and manipulating the role of network activity in the developing human cortex. Applications for neurodevelopmental disorders and brain evolution will be discussed.

Thursday 1745 1800

Final Remarks @ Rooms 4-6 Chairs: Dan Holmes and Cory Bystrom The Scientific Committee Chair and Vice Chair wrap up MSACL and share information about upcoming Conferences. IMSS Special Topic Scientific Sessions continue through Friday morning. 1537

Thursday 1930 2200

Hospitality Lounge @ Gypsy Rose 1539

Friday

Scientific Session 9

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	Track 1 Room 1 Imaging Mass Spectrometry Society Special Session I Chair: Chris Anderton 2nd Chair: Jessica Lukowski	Track 2 Room 2 TBA Chair: TBA	Track 3 Room 3 TBA Chair: TBA	Track 4 Room 4 TBA Chair: TBA	Track 5 Room 5 TBA Chair: TBA	Track 6 Room 6 TBA Chair: TBA
830 850	TBA	CLOSED	CLOSED	CLOSED	CLOSED	CLOSED
850 910	TBA	CLOSED	CLOSED	CLOSED	CLOSED	CLOSED
910 930	TBA	CLOSED	CLOSED	CLOSED	CLOSED	CLOSED

830 1030

Scientific Committee Leads 2021 Planning Meeting @ Room 4 Chair: Amber Herold Closed meeting for SciCom Leads and Admin to prepare for 2021!

Friday 930 945

Intermission @ Ballroom Foyer 1619

Scientific Session 10

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	Track 1 Room 1 Imaging Mass Spectrometry Society Special Session II Chair: Chris Anderton 2nd Chair: Jessica Lukowski	Track 2 Room 2 TBA Chair: TBA	Track 3 Room 3 TBA Chair: TBA	Track 4 Room 4 TBA Chair: TBA	Track 5 Room 5 TBA Chair: TBA	Track 6 Room 6 TBA Chair: TBA
945 1005	TBA	CLOSED	CLOSED	CLOSED	CLOSED	CLOSED
1005 1025	TBA	CLOSED	CLOSED	CLOSED	CLOSED	CLOSED
1025 1045	TBA	CLOSED	CLOSED	CLOSED	CLOSED	CLOSED

Friday 1045 1100

Intermission @ Ballroom Foyer 1621

Scientific Session 11

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	Track 1 Room 1 Imaging Mass Spectrometry Society Special Session III Chair: Chris Anderton 2nd Chair: Jessica Lukowski	Track 2 Room 2 TBA Chair: TBA	Track 3 Room 3 TBA Chair: TBA	Track 4 Room 4 TBA Chair: TBA	Track 5 Room 5 TBA Chair: TBA	Track 6 Room 6 TBA Chair: TBA
1100 1120	TBA	CLOSED	CLOSED	CLOSED	CLOSED	CLOSED
1120 1140	TBA	CLOSED	CLOSED	CLOSED	CLOSED	CLOSED
1140 1200	TBA	CLOSED	CLOSED	CLOSED	CLOSED	CLOSED

Friday 1200 1215

Closing Remarks @ Room 1 Chair: Chris Anderton Wrap up of IMSS Special Topics and information about upcoming Conferences. 1625

Friday 1215

Conference Closed @ Ballroom Foyer 1540