= Emerging. More than 5 years before clinical availability. (30.48%)
= Expected to be clinically available in 1 to 4 years. (40.00%)
= Clinically available now. (29.52%)
Percent of confirmed presenters indicating Clinical Use Status: 100.00%



MSACL 2020 US: Conference Program

Palm Springs, CA • March 28 - April 3, 2020

With Thanks to Our Conference Sponsors:
Shimadzu Thermo
GoldenWest Diagnostics Indigo Agilent
Biotage UTAK Kura Biotech
And Special Thanks to Our Educational Grant Sponsors:
Brian Kelly
Brian Rappold
Russell Grant
Danyel Tacker
Andy Hoofnagle
David Herold

Sunday

800
1800
Badge Pickup
@ RegDesk @ Ballroom Foyer
900
1200

Short Course

These Short Courses have not yet been assigned to Groups. Times are not final.
COURSE START
LC-MSMS 101
Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory
Judy Stone, PhD & Deborah French, PhD
Level: Beginner - Intermediate
@ TBD
Group: TBD
1200
1300
Lunch for LC-MSMS 101
@ The Palmetto Restaurant
1300
1800

Short Course

These Short Courses have not yet been assigned to Groups. Times are not final.
COURSE START
Data Science 101
Breaking up with Excel: An Introduction to the R Statistical Programming Language
Daniel Holmes, MD & Will Slade, PhD
Level: Beginner
@ TBD
Group: TBD
COURSE START
Data Science 201
Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling
Patrick Mathias, MD, PhD & Shannon Haymond, PhD
Level: Beginner-Intermediate
@ TBD
Group: TBD
COURSE START
LC-MSMS 101
Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory
Judy Stone, PhD & Deborah French, PhD
Level: Beginner - Intermediate
@ TBD
Group: TBD
COURSE START
LC-MSMS 202
Practical LC-MS Maintenance and Troubleshooting
J. Will Thompson, PhD & Chris Shuford, PhD
Level: Intermediate
@ TBD
Group: TBD
COURSE START
Metabolomics 201
Application of High Resolution Mass Spectrometry and Metabolomics in Clinical Analysis
Timothy Garrett, PhD & Erin Baker, PhD
Level: Intermediate
@ TBD
Group: TBD
COURSE START
Proteomics 201
Clinical Proteomics
Andy Hoofnagle, MD, PhD & Cory Bystrom, PhD
Level: Intermediate - Advanced
@ TBD
Group: TBD
COURSE START
Sample Prep 201
Sample Preparation and Alternative Matrices for LC-MS Assays
William Clarke, PhD & Mark Marzinke, PhD
Level: Beginner - Intermediate
@ TBD
Group: TBD
1800
2000
Poolside Dinner
@ Chiki Pool
2000
2100
Hospitality Lounge
@ Chiki Pool
2000
2100
Hospitality Lounge (Rain)
@ The Landing

Monday

700
1800
Badge Pickup
@ RegDesk @ Ballroom Foyer
700
830
Breakfast
@ Gypsy Rose, Palmetto & Cantala
800
1200

Short Course

These Short Courses have not yet been assigned to Groups. Times are not final.
Continued from Sunday
Data Science 101
Breaking up with Excel: An Introduction to the R Statistical Programming Language
Daniel Holmes, MD & Will Slade, PhD
Level: Beginner
@ TBD
Group: TBD
Continued from Sunday
Data Science 201
Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling
Patrick Mathias, MD, PhD & Shannon Haymond, PhD
Level: Beginner-Intermediate
@ TBD
Group: TBD
COURSE START
Data Science 203
Machine Learning : A Gentle Introduction
Stephen Master, MD, PhD & Randy Julian, PhD
Level: Intermediate
@ TBD
Group: TBD
COURSE START
Imaging 202
"iMSACL": Clinical Studies using Imaging Mass Spectrometry
Michelle Reyzer, PhD, and Christina Ferreira, PhD, and Sankha (Bobby) Basu, MD, PhD
Level: Beginner-Intermediate
@ TBD
Group: TBD
Continued from Sunday
LC-MSMS 101
Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory
Judy Stone, PhD & Deborah French, PhD
Level: Beginner - Intermediate
@ TBD
Group: TBD
Continued from Sunday
LC-MSMS 202
Practical LC-MS Maintenance and Troubleshooting
J. Will Thompson, PhD & Chris Shuford, PhD
Level: Intermediate
@ TBD
Group: TBD
COURSE START
Lipidomics 101
Mass Spectrometry-based Lipidomics and Clinical Applications
Anne K Bendt, PhD, Amaury Cazenave-Gassiot, PhD & Michael Chen, MD MSc
Level: Beginner - Intermediate
@ TBD
Group: TBD
COURSE START
MALDI 103
MALDI-MS Fundamentals and its Emerging Role in Pathology and Laboratory Medicine
Mari L. DeMarco, PhD DABCC FACB FCACB & Teesha Luehr
Level: Beginner - Intermediate
@ TBD
Group: TBD
Continued from Sunday
Metabolomics 201
Application of High Resolution Mass Spectrometry and Metabolomics in Clinical Analysis
Timothy Garrett, PhD & Erin Baker, PhD
Level: Intermediate
@ TBD
Group: TBD
Continued from Sunday
Proteomics 201
Clinical Proteomics
Andy Hoofnagle, MD, PhD & Cory Bystrom, PhD
Level: Intermediate - Advanced
@ TBD
Group: TBD
Continued from Sunday
Sample Prep 201
Sample Preparation and Alternative Matrices for LC-MS Assays
William Clarke, PhD & Mark Marzinke, PhD
Level: Beginner - Intermediate
@ TBD
Group: TBD
COURSE START
Toxicology 201
Advanced Forensic Toxicology
Russell Lewis, Ph.D., F-ABFT & Robert Johnson, PhD, F-ABFT
Level: Intermediate - Advanced
@ TBD
Group: TBD
1230
1330
Short Course Lunch
@ Cantala Restaurant
1300
1700

Short Course

These Short Courses have not yet been assigned to Groups. Times are not final.
Continued from Monday AM
Data Science 101
Breaking up with Excel: An Introduction to the R Statistical Programming Language
Daniel Holmes, MD & Will Slade, PhD
Level: Beginner
@ TBD
Group: TBD
Continued from Monday AM
Data Science 201
Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling
Patrick Mathias, MD, PhD & Shannon Haymond, PhD
Level: Beginner-Intermediate
@ TBD
Group: TBD
Continued from Monday AM
Data Science 203
Machine Learning : A Gentle Introduction
Stephen Master, MD, PhD & Randy Julian, PhD
Level: Intermediate
@ TBD
Group: TBD
Continued from Monday AM
Imaging 202
"iMSACL": Clinical Studies using Imaging Mass Spectrometry
Michelle Reyzer, PhD, and Christina Ferreira, PhD, and Sankha (Bobby) Basu, MD, PhD
Level: Beginner-Intermediate
@ TBD
Group: TBD
Continued from Monday AM
LC-MSMS 101
Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory
Judy Stone, PhD & Deborah French, PhD
Level: Beginner - Intermediate
@ TBD
Group: TBD
Continued from Monday AM
LC-MSMS 202
Practical LC-MS Maintenance and Troubleshooting
J. Will Thompson, PhD & Chris Shuford, PhD
Level: Intermediate
@ TBD
Group: TBD
Continued from Monday AM
Lipidomics 101
Mass Spectrometry-based Lipidomics and Clinical Applications
Anne K Bendt, PhD, Amaury Cazenave-Gassiot, PhD & Michael Chen, MD MSc
Level: Beginner - Intermediate
@ TBD
Group: TBD
Continued from Monday AM
MALDI 103
MALDI-MS Fundamentals and its Emerging Role in Pathology and Laboratory Medicine
Mari L. DeMarco, PhD DABCC FACB FCACB & Teesha Luehr
Level: Beginner - Intermediate
@ TBD
Group: TBD
Continued from Monday AM
Metabolomics 201
Application of High Resolution Mass Spectrometry and Metabolomics in Clinical Analysis
Timothy Garrett, PhD & Erin Baker, PhD
Level: Intermediate
@ TBD
Group: TBD
Continued from Monday AM
Proteomics 201
Clinical Proteomics
Andy Hoofnagle, MD, PhD & Cory Bystrom, PhD
Level: Intermediate - Advanced
@ TBD
Group: TBD
Continued from Monday AM
Sample Prep 201
Sample Preparation and Alternative Matrices for LC-MS Assays
William Clarke, PhD & Mark Marzinke, PhD
Level: Beginner - Intermediate
@ TBD
Group: TBD
Continued from Monday AM
Toxicology 201
Advanced Forensic Toxicology
Russell Lewis, Ph.D., F-ABFT & Robert Johnson, PhD, F-ABFT
Level: Intermediate - Advanced
@ TBD
Group: TBD
1700
1900
Hospitality Lounge
@ Soleil Pool
1730
1930
Dinner on Own
@ YourChoice

Some places to try in walking distance:
1. Draughtsman, 3:00 to 10pm, Craft beers, outdoor games. Settle in.
2. Sandfish, Sushi and whiskey pairings. 4:30 to 10pm.
3. Billy Reeds, American comfort food, good for large groups. 8am-10pm.
4. JJ's Latin Oasis, Mexican food, Chris Herold's favorite stop in Palm Springs since 1995.

Have an ice cream after dinner at ICE CREAM SHOPPE open noon to 11pm.
1830
2000
Faculty Dinner
@ Chiki Pool

Tuesday

700
2000
Badge Pickup
@ RegDesk @ Ballroom Foyer
700
830
Breakfast
@ Gypsy Rose, Palmetto & Cantala
800
1100

Short Course

These Short Courses have not yet been assigned to Groups. Times are not final.
Continued from Monday PM
Data Science 101
Breaking up with Excel: An Introduction to the R Statistical Programming Language
Daniel Holmes, MD & Will Slade, PhD
Level: Beginner
@ TBD
Group: TBD
Continued from Monday PM
Data Science 201
Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling
Patrick Mathias, MD, PhD & Shannon Haymond, PhD
Level: Beginner-Intermediate
@ TBD
Group: TBD
Continued from Monday PM
LC-MSMS 202
Practical LC-MS Maintenance and Troubleshooting
J. Will Thompson, PhD & Chris Shuford, PhD
Level: Intermediate
@ TBD
Group: TBD
Continued from Monday PM
MALDI 103
MALDI-MS Fundamentals and its Emerging Role in Pathology and Laboratory Medicine
Mari L. DeMarco, PhD DABCC FACB FCACB & Teesha Luehr
Level: Beginner - Intermediate
@ TBD
Group: TBD
Continued from Monday PM
Metabolomics 201
Application of High Resolution Mass Spectrometry and Metabolomics in Clinical Analysis
Timothy Garrett, PhD & Erin Baker, PhD
Level: Intermediate
@ TBD
Group: TBD
Continued from Monday PM
Proteomics 201
Clinical Proteomics
Andy Hoofnagle, MD, PhD & Cory Bystrom, PhD
Level: Intermediate - Advanced
@ TBD
Group: TBD
0840
1150

Get the Basics
An overview of the fundamentals that are driving research and development.

Room 4 Chairs: TBA
Room 5 Chairs: TBA

This series of Primers on fields within Clinical Mass Spec is free to attend for ALL registrants of the MSACL Congress or Short Courses, including Partial Pass holders.

Takeaways for each session include:

  1. Be able to define what the field is, why it matters, and why you personally should care. What is the clinical relevance?
  2. Understand what role mass spectrometry plays in this field. Where does mass spec fit in to the big picture of the field?
  3. Define any terminology that is specific to this field.
  4. Describe how it works, what are the methods and workflows used when studying this field and/or how is it implemented in clinical labs.
  5. Identify any challenges to implementation/adoption, where do the opportunities lie?

08:40 - 09:20
  • Room 4: Metabolomics with Adam Rosebrock
  • Room 5: TBA
09:30 - 10:10
  • Room 4: Proteomics with Tim Collier
  • Room 5: Lipidomics with Anne Bendt
10:20 - 11:00
  • Room 4: Toxicology with Paul Jannetto
  • Room 5: Imaging Mass Spectrometry with Ron Heeren
11:10 - 11:50
  • Room 4: Sample Preparation with Mark Marzinke
  • Room 5: Data Science with Alfonso Limon
1100
1600
Place Wed Posters
@ Exhibit Hall
1200
1330

Lunch Vendor Workshop(s)

Indigo BioAutomation
@ Rm1

Workshop summary coming soon ...

1400
1415
Welcome Orientation
@ Rooms 4-6
1415

Opening Plenary Lecture


@ Rooms 4-6

1415
1500

Michael Angelo
Stanford Bio-X

1500
1515
Intermission
@ Ballroom Foyer
1515
1600

State of the Science Address
@ Rooms 4-6

Presented by MSACL US Scientific Committee Topic Leads, this address will provide an overview of the applications and technologies currently being used in Clinical Labs, and a clear view of the development pipeline. It will highlight applications expected to be available in the near-future, as well as emerging applications, and key contributors. Relevant talks, posters, and people present at the congress will be identified, enabling you to optimize your learning path and more effectively target potential network connections. Whether you are new to Clinical Mass Spectrometry, or a seasoned veteran, the State of the Science address should be on your agenda.
1600
1615
Intermission
@ Ballroom Foyer
1615
1645
Poster Lightning Talks
@ Rooms 4-6

90 seconds, one slide. Up to 15 poster presentations highlighted.
1645
1715
Vendor Lightning Talks
@ Rooms 4-6

90 seconds, one slide. Up to 20 vendors highlighted.
1715
2000
Exhibits Dinner Reception
@ Exhibit Hall
1800
1900
Meet-a-Mentor: Booth Tours
@ Exhibit Hall

Join a mentor as they tour the booths and learn more about technologies available, what mentors are looking for during the exchange, and how they interact with the booth vendors. Increase your network and your knowledge of products and services available.
1900
2000
Troubleshooting Forum: Poster Rounds
@ Exhibit Hall

Join the troubleshooting poster discussion to learn something new or add your two cents.
No Troubleshooting Posters have yet been booked for this event.

2000
2100

Discussion Group: CDC Clinical Standardization Programs Forum
Chair: Hubert Vesper
Overview of ongoing and new CDC’s Standardization Programs

2000
2100

Discussion Group: From the Operating Room to the Mass Spec: Handling and Storage of Human Tissue Samples
Chair: Chris Anderton
Hosted by IMSS.

We will discuss patient-specific effects, sample collection, transport and handling of samples, and tissue preparation when acquiring and interpreting mass spectrometry data. We will especially focus on how these steps effect imaging mass spectrometry data, but many of these topics translate universally across mass spectrometry approaches in general.

This will be an open forum with predefined topics to guide the conversation.

2000
2100

Discussion Group: Clinical Cases – Where Mass Spec made a Difference in Patient Care
Hosted by AACC and moderated by Carmen Wiley, 2020 President of AACC.
Speakers: Nicole Tolan, Dennis Dietzen, and Stephen Master
Mass spectrometry continues to play a prominent role in the field of laboratory medicine. In this session, each speaker will highlight a clinical case where Mass Spec Analysis has made all the difference in a patient's care and outcome.
Learning objectives:
After completing this activity, the learner will be able to:
1. site examples where mass spectrometry made a difference in patient care
2. describe how mass spectrometry could play an important in their institutions
3. summarize the role of mass spectrometry played in each of these case studies
Speakers:
Nichole Tolan, Assistant Professor of Pathology at Harvard Medical School
Dennis Dietzen, Professor, Pathology & Immunology at Washington University School of Medicine
Stephen Master, Associate Professor of Pathology and Laboratory Medicine at the Children's Hospital of Philadelphia

2000
2200
Hospitality Lounge
@ Soleil Pool

Wednesday

700
1800
Badge Pickup
@ RegDesk @ Ballroom Foyer
745
815
Breakfast
@ Ballroom Foyer

Pre-Workshop Breakfast
800
845

Corporate Workshop(s)

Biotage
@ Rm1

Workshop summary coming soon ...

Thermo Fisher Scientific
@ Rm2

Workshop summary coming soon ...

SCIEX
@ Rm4

Workshop summary coming soon ...

Agilent Technologies
@ Rm5

Workshop summary coming soon ...

Indigo BioAutomation
@ Rm6

Workshop summary coming soon ...

845
900
Intermission
@ Ballroom Foyer

Scientific Session 1

Track 1
Room 1

Tox/TDM/Endocrine: Order of Operations: Workflow Optimization and Quality Improvements for Mass Spectrometry
Chair: Stephen Roper (pending)
2nd Chair: Scott Borden (pending)

Track 2
Room 2

Standardization and Normalization of Metabolomic and Lipidomic Workflows (1)
Chair: Melanie Odenkirk (pending)

Track 3
Room 3

Data Science Keynote: Olga Vitek
Chair: Randall Julian (pending)

Track 4
Room 4

Imaging MS: In the Clinic
Chair: Peggi Angel (pending)
2nd Chair: Anna Krieger (pending)

Track 5
Room 5

Proteomics: Innovating New Biomarkers
Chair: TBA

Track 6
Room 6

Practical Training
Chair: Hema Ketha (pending)
2nd Chair: Deborah French (pending)

900
920
A Suggested Standard for Validation of LC-MS/MS-based Analytical Series (batches) in Diagnostic Laboratories
Judith Stone
Univ of California, San Francisco Health
Quality Control Strategies for Untargeted Clinical Metabolomics
Lisa Ford
Metabolon, Inc
Components of Reproducible Quantitative Mass Spectrometry-based Proteomics: A Statistician’s Perspective
Olga Vitek
Northeastern University
A Rapid MALDI Mass Spectrometry Imaging Method to Complement the Frozen Section Procedure in Surgical Pathology
Sankha Basu
Brigham and Women’s Hospital, Harvard Medical School
Quantification of Fully and Partially Acetylated HMGB1 Protein in the Serum and Pleural Effusion of Mesothelioma and Non-mesothelioma Individuals
Weston Spivia
Cedars Sinai Medical Center
Mastering Mass Spectrometry in the Clinic – Cases and Chronicles
Hema Ketha, Jennifer Colby
920
940
HarmCheck: Paper Spray Mass Spectrometry (PS-MS) for Harm Reduction Drug Checking and its Utility for the Opioid Overdose Crisis
Chris Gill
University of Victoria (AERL-VIU)
Development of Clinical Lipidomics Accompanied with Standardization and Harmonization by the International Lipidomics Society (ILS)
Kim Ekroos
Lipidomics Consulting Ltd
...
Keynote
...
Intraoperative Use of the MasSpec Pen Technology for Ex Vivo and In Vivo Analysis of Human Breast Tissues
Kyana Garza
The University of Texas at Austin
Development of a Multiplexed Urine Protein Panel for Prognosis of Chronic Kidney Disease
Angela Mc Ardle
Cedars Sinai Medical Centre
...
Extended Session
...
940
1000
How Ion Trap Mass Spectrometry Changed Our Toxicology Workflow
Nicholas Laude
Genotox Laboratories
Shared Reference Materials Harmonize Lipidomics in Human Plasma Across MS-based Detection Platforms and Laboratories
Federico Torta
National University of Singapore
...
Keynote
...
Rapid Evaporative Ionization Mass Spectrometry – Towards real-time molecular profiling of tissue during skin cancer surgery
Natasja Janssen
Queen’s University
The 3D Proteome and the Potential for Conformational Biomarkers
John Yates
Scripps Research
...
Extended Session
...
1000
1100
Exhibits & Poster Session
@ Exhibit Hall

Even 'a' poster positions to be attended.

Scientific Session 2

Track 1
Room 1

Not Your Average Cannabinoids
Chair: Jen Colby (pending)
2nd Chair: Chris Koch (pending)

Track 2
Room 2

Beyond Metabolomics -or- Lipidomics: Mutli-omic Analysis of Patient Samples
Chair: Elizabeth Want (pending)

Track 3
Room 3

Data Flow
Chair: Will Slade (pending)

Track 4
Room 4

Imaging MS Keynote: Lingjun Li
Chair: Richard Drake (pending)

Track 5
Room 5

Proteomics: Clinical Biomarker Assays - Revamped
Chair: TBA

Track 6
Room 6

Practical Training
Chair: Elizabeth Frank (pending)
2nd Chair: Jacqueline Hubbard (pending)

1100
1120
Clearing a Haze of Confusion; Differentiating CBD Use from Marijuana Use in Urine Drug Testing
Gregory Janis
Medtox / Labcorp
Full-scan Metabolomic Profiling of Glioblastoma Stem Cells Discovers Metabolic Pathway Variation Associated with Clinical Outcomes
Amy Caudy
Stony Brook University
Applied “R” for Error Reduction: Hands-free Seamless LC-MS/MS Batch Data Flow
Hema Ketha
Labcorp
Mapping the Chemical Space of Biological Systems via MALDI Mass Spectrometric Imaging and <i>in situ</i> Molecular Analysis
Lingjun Li
University of Wisconsin - Madison - Madison, WI
Clinical Validation of an LC-MS/MS Assay for Measurement of Serum C-peptide
Benjamin Owusu
University of Washington
Free Climb or Free Solo: Guidance and Accounts of Establishing Reference Intervals for LDT Mass Spectrometry Assays
Elizabeth Frank, Kelly Doyle
1120
1140
Correlation of Vitamin K1 Treatments with Plasma Concentrations of Anticoagulant Rodenticides following Inhalation of Contaminated Synthetic Cannabinoids
Richard van Breemen
Oregon State University
A Multi-omic Assessment of Unique Alzheimer’s Disease Mechanisms Reflective of ApoE Genotype Differences
Melanie Odenkirk
North Carolina State University
Speaking to Your Mass Spectrometer: A Toolkit to Visualize Mass Spectrometer Data
Abed Pablo
University of Washington
...
Keynote
...
Dilute, Digest and Detect: Quantification of C-reactive Protein in Human Plasma by LC-MS/MS
Meng Wang
University of British Columbia
...
Extended Session
...
1140
1200
Development of an LC-MS/MS Assay for the Analysis of Endogenous Cannabinoid Plasma Concentrations
Raymond Suhandynata
University of California San Diego
Moving Forward Towards Diagnostic for Predisposition to Food Allergy and Atopic Dermatitis Through LC-MS/MS Analysis of Stratum Corneum on Skin Tape Strips
Evgeny Berdyshev
National Jewish Health
Data Analytics Hose to Data Analytics Pipeline
Wesley Hampton
Nationwide Children’s Hospital
...
Keynote
...
Lessons in Surrogate Peptide Selection and Calibration from Development of an ApoA1 Assay
Mari DeMarco
University of British Columbia
...
Extended Session
...
1200
1400
Lunch On Own
@ YourChoice
1230
1330

Corporate Workshop(s)

Shimadzu
@ Rm1

Workshop summary coming soon ...

Thermo Fisher Scientific
@ Rm2

Workshop summary coming soon ...

Bruker
@ Rm4

Workshop summary coming soon ...

Agilent Technologies
@ Rm5

Workshop summary coming soon ...

Scientific Session 3

Track 1
Room 1

Fentanyl at the Forefront: Using Non-traditional Approaches to Identify Fentanyl Analogs
Chair: Hema Ketha (pending)
2nd Chair: Melissa Hoffman (pending)

Track 2
Room 2

Lipidomics of Hepatic Disease - with a Focus on Imaging Mass Spectrometry
Chair: Frederico Torta (pending)

Track 3
Room 3

Microbiology Keynote: Robert Cody
Chair: TBA

Track 4
Room 4

Imaging MS: Translational Research
Chair: Reid Groseclose (pending)
2nd Chair: Aalim Weljie (pending)

Track 5
Room 5

Proteomics: Established Biomarkers Done Better
Chair: TBA

Track 6
Room 6

Practical Training
Chair: Grace van der Gugten (pending)

1400
1420
A Semi-targeted Approach for Detecting Fentanyl Analogs in Urine Using Precursor Ion Scan Mode
Stephen Roper
Washington University School of Medicine
Sodium-doped Gold-assisted Imaging Mass Spectrometry Reveals Alterations in Triglyceride Distribution in NAFLD Human Liver as Conditions Progress
Ethan Yang
University of Montreal
The State of the DART: Does Direct Analysis in Real-Time Mass Spectrometry have a Future in Clinical Chemistry?
Robert Cody
JEOL USA, Inc
Deciphering Racial Disparities in Breast Cancer Collagen Re-alignment by Targeted Extracellular Matrix Proteomics
Peggi Angel
Medical University of South Carolina
Measurement of Immature Reticulocyte Proteins in Dried Blood Spots
Holly Cox
Sports Medicine Research and Testing Laboratory
What Do You Do When Your Good Assay Goes Bad?
Sarah Shugarts, Howard Horng
1420
1440
Using High Resolution Mass Spectrometry to Evaluate Trends in Fentanyl Analogues Prevalence and Other False Positives in Emergency Medicine Patients
Adina Badea
University of California - San Francisco
Lipid Profiling and Imaging Predict Proliferation Status of Hepatocellular Carcinoma
Zoe Hall
Imperial College London
...
Keynote
...
Integrating Desorption Electrospray Ionization Mass Spectrometry Imaging and Fluorescence In-situ Hybridization for the Detection of Circulating Tumor Cells
Alena Bensussan
University of Texas at Austin
Innovation and Discovery in Operations: Isotopic Peak Index, Relative Retention Time and Tandem MS for Detection of 15 IGF-1 Variants in Clinical Analysis
Ievgen Motorykin
Quest Diagnostics
...
Extended Session
...
1440
1500
Development of a Fentanyl Analogue Screening Library for High-Resolution Mass Spectrometry
Jada (Yu) Zhang
Zuckerberg San Francisco General Hospital, UCSF
Lipidomic Signatures in Patients with Varying Histological Severity of Non-alcoholic Fatty Liver Disease
Sneha Muralidharan
National University of Singapore
...
Keynote
...
Imaging Mass Spectrometry of Lipids in Retina Deposits of Aged Human Eyes
Kevin Schey
Vanderbilt University
Automation and Implementation of a Nanobody-MALDI-TOF Platform for Rapid Detection and Isotyping of Monoclonal Gammopathies
Surendra Dasari
Mayo Clinic
...
Extended Session
...
1500
1615
Exhibits & Poster Session
@ Exhibit Hall

Odd 'a' poster positions to be attended.
1515
1600
Meet-a-Mentor: Poster Tours 1
@ Exhibit Hall

Join a mentor as they tour the posters. Learn more about what mentors are looking for in a poster, and how they engage the presenter.
1600
1615
Remove Wed Posters
@ Exhibit Hall

Scientific Session 4

Track 1
Room 1

A 360ᵒ View of Immunosuppressants: Assay Development to Clinical Applications
Chair: Mark Marzinke (pending)
2nd Chair: Ganesh Moorthy (pending)

Track 2
Room 2

Metabolomics of Small Volume Specimens - Doing More with DBS
Chair: Amy Caudy (pending)

Track 3
Room 3

Data Science Keynote: Andrea Geistanger
Chair: Stephen Master (pending)

Track 4
Room 4

Imaging MS: Biomarkers
Chair: Kevin Schey (pending)
2nd Chair: Marissa Jones (pending)

Track 5
Room 5

Pinky and the Brain Proteomics
Chair: TBA

Track 6
Room 6

Practical Training
Chair: Matt Crawford (pending)
2nd Chair: Deborah French (pending)

1615
1635
Determination of Sirolimus, Everolimus, Tacrolimus and Cyclosporin in Whole Blood by LC-MS/MS for Therapeutic Drug Monitoring
Natalicia De Jesus Antunes
Queen Mary University of London
A Novel Tandem MS Approach to Dried Blood Spot Analysis of Homocysteine, Methylmalonic Acid, and Methylcitric Acid in the Newborn Screening Laboratory
Joshua Dubland
University of British Columbia
MCR and VCA – Two R Packages to Facilitate Your Method Comparison and Precision Studies
Andrea Geistanger
Roche Diagnostics GmbH
Investigating Cardiolipin Aberrations in Gliomas Using Desorption Electrospray Ionization High Field Asymmetric Ion Mobility Mass Spectrometry Imaging
Anna Krieger
University of Texas at Austin
Characterization of Pre-analytical Variables and their Influence on High-performance Plasma Amyloid-β Biomarkers for Alzheimer’s Disease
James Boslett
University of Pittsburgh
Working Smarter Not Harder on Sample Prep
Matthew Crawford
Labcorp
1635
1655
Accurate Recovery of Immunosuppressant Drugs from Blood: The Tale of a Tortoise and a Hare
Stacy Dee
Laboratory Corporation of America
High Resolution Mass Spectrometry Newborn Screening Applications for Quantitative Analysis of Amino Acids and Acylcarnitines in Dried Blood Spots
Austin Pickens
Centers for Disease Control and Prevention
...
Keynote
...
Spatially-targeted Proteomics for Analysis of Staphylococcus aureus Abscess Formation
Emma Guiberson
Vanderbilt University
Measurement of CSF Hypothalamic Peptides in Frontotemporal Dementia Using LC-MS/MS
Carolin Heller
University College London (UCL)
...
Extended Session
...
1655
1715
Unexpected Toxic Tacrolimus Levels in Pediatric Heart Transplant Patient
Gang Xu
Medical University of South Carolina
Moving Genetic Diseases from a Single Endpoint- to a Pattern-based Diagnosis Using Metabolomics
Anas Abdel Rahman
King Faisal Specialist Hospital and Research Cente
...
Keynote
...
Imaging Mass Spectrometry Analysis of Glycans from Tissue to Serum - Identification and Validation of Biomarkers for Hepatocellular Carcinoma
Anand Mehta
Medical University of South Carolina
Spatio Temporal Proteomic Guided by MALDI MSI Opens the Door of Therapy for Spinal Cord Injury
Michel Salzet
Université De Lille, Inserm U1192
...
Extended Session
...
1715
1830
Exhibits & Appetizers
@ Exhibit Hall
1715
1730
Place Thu Posters
@ Exhibit Hall
1730
1830
Meet-a-Mentor: Office Hours
@ Exhibit Hall

Have a question from the congress that you have been itching to ask? Or a problem from work that you want to get feedback on? Or feedback on the congress? Sign up at the registration desk for 15-min blocks to share time and ideas with a mentor in a relaxed setting.
1730
1830
Troubleshooting Forum: Poster Rounds
@ Exhibit Hall

Join the troubleshooting poster discussion to learn something new or add your two cents.
No Troubleshooting Posters have yet been booked for this event.

1845

Distinguished Contribution Award Plenary Lecture


@ Rooms 4-6

1845
1945

On the Award


Alan Rockwood
Professor Emeritus, University of Utah

1945
2200
No Host Pool Party
@ Soleil Pool
2000
2100

FeMS: Award Presentation and Discussion Group
1. Presentation of The Catherine E Costello Award for Females in Mass Spectrometry sponsored by Avanti Polar Lipids.
2. Small group networking and guided discussion regarding topics relevant to Females in Mass Spectrometry.

2000
2100

METASPACE
Chair: Theodore Alexandrov
A workshop to discuss METASPACE.

The METASPACE platform hosts an engine for metabolite annotation of imaging mass spectrometry data as well as a spatial metabolite knowledgebase of the metabolites from hundreds of public datasets provided by the community.

2000
2115

The Status of Clinical Mass Spectrometry in Asia
Chair: Michael Chen

Thursday

745
815
Breakfast
@ Ballroom Foyer

Have breakfast at a workshop.
800
845

Corporate Workshop(s)

PerkinElmer
@ Rm1

Workshop summary coming soon ...

Chromsystems
@ Rm2

Workshop summary coming soon ...

Waters
@ Rm4

Workshop summary coming soon ...

Restek
@ Rm5

Workshop summary coming soon ...

MilliporeSigma
@ Rm6

Workshop summary coming soon ...

845
900
Intermission
@ Ballroom Foyer

Scientific Session 5

Track 1
Room 1

Targeted Mass Spectrometric Applications for Targeted Populations
Chair: Richard Van Breemen (pending)
2nd Chair: Ruben Luo (pending)

Track 2
Room 2

Discovery Metabolomics of Clinical Cohorts
Chair: Amy Caudy (pending)

Track 3
Room 3

Data Science: Toxicology
Chair: Lindsay Bazydlo (pending)

Track 4
Room 4

Microbiology: New and Experimental Approaches in Microbial Mass Spectrometry
Chair: Chris Cox (pending)

Track 5
Room 5

Proteomics Keynote: Michael Lassman
Chair: TBA

Track 6
Room 6

Practical Training
Chair: Will Thompson (pending)
2nd Chair: Judy Stone (pending)

900
920
High Resolution Mass Spectrometry to Quantitatively Determine Modulations in Estrogen Metabolism for Postmenopausal Women Consuming Botanical Dietary Supplement
Alan Wong
Linus Pauling Institute, Oregon State University
MS-based Metabolomics Reveal Bile Acid Metabolism Dysregulation in Malnourished Children from Study of Environmental Enteropathy and Malnutrition
Xueheng Zhao
Cincinnati Children’s Hospital
Creation of a Review by Exception Workflow in DI to Automate Resulting of Interpretive Reports for Confirmatory Opiate Drug Testing
Benjamin Beppler
Tricore Reference Laboratories
Identification of Clinically Relevant Microbes with the MasSpec Pen
Sydney Povilaitis
University of Texas at Austin
The Changing Landscape of Immune-oncology and How Mass Spectrometry Might Help Guide Patient Care
Michael Lassman
Merck & Co
System Suitability and Real-time Quality Control Using Skyline and Panorama
J. Will Thompson, Chris Shuford, Mike MacCoss
920
940
Serum Indoxyl Sulfate and p-Cresyl Sulfate in Patients with Chronic Kidney Disease
Chia-Ni Lin
Chang Gung Memorial Hospital
A Metabolomic Analysis of the Hispanic Paradox
Jeffrey Patterson
Arizona State University
An Interactive Dashboard for Toxicology Results Using the R Shiny Package
Alex Mays
University of Washington
Development of Metal Oxide Laser Ionization Mass Spectrometry Imaging (MOLI MSI) for Pathogen Detection in Tissues
Madison Mcminn
Northeastern University
...
Keynote
...
...
Extended Session
...
940
1000
Development of a LC-MS/MS Method to Measure Sulfated and Glucruonidated 25OHD3; Comparisons to Unconjugated 25OHD in Circulation
Carl Jenkinson
University of Birmingham
A Novel UPLC-MS Approach for Metabotyping Burn Injury
Elizabeth Want
Imperial College London
Discovering Cross-reactivity in Urine Drug Screening Immunoassays Through Large-scale Analysis of Electronic Health Records
Jake Hughey
Vanderbilt University Medical Center
Next-generation Infection Diagnostics
Vladimir Havlicek
Institute of Microbiology
...
Keynote
...
...
Extended Session
...
1000
1100
Exhibits & Poster Session
@ Exhibit Hall

Even 'b' poster positions to be attended.
1015
1100
Meet-a-Mentor: Poster Tours 2
@ Exhibit Hall

Join a mentor as they tour the posters.

Scientific Session 6

Track 1
Room 1

Tox/TDM/Endocrine Keynote: Thomas Rosano
Chair: Jen Colby (pending)

Track 2
Room 2

Glycomics
Chair: Richard Drake (pending)

Track 3
Room 3

Microbiology Workshop
Chair: Chris Cox (pending)

Track 4
Room 4

Imaging MS: Therapeutic Targets
Chair: David Muddiman (pending)
2nd Chair: Yusheng Zhu (pending)

Track 5
Room 5

Omics Data Science
Chair: Irene van den Broek (pending)

Track 6
Room 6

Practical Training
Chair: Zlata Clark (pending)
2nd Chair: Jacqueline Hubbard (pending)

1100
1120
Evolving Role of Nominal and High Resolution Mass Spectroscopy in Routine Toxicology Casework
Thomas Rosano
National Toxicology Center; Albany Medical College
Antibody Panel Based N-glycan Profiling by MALDI MS for N-Glycoprotein Biomarker Discovery from Patient Biofluids
Alyson Black
Medical University of South Carolina
Practical Training: On the Utility of Clinical Mass Spectrometry for Microbial Diagnostics
Chris Cox
Cobio Diagnostics
Metabolic Profiling of MYC-induced Tumors by DESI-MSI to Identify Possible Druggable Targets
Katy Margulis
The Hebrew University of Jerusalem
Supervised Data Processing and Quality Control of Mass Spectrometry-based Lipidomics Analyses Using LIDAR, a Novel Toolbox Implemented in R/Shiny
Bo Burla
National University of Singapore
Taking Aim at Analytical Interference in LC-MS Without Shooting Yourself in the Foot
Zlata Clark
ARUP Laboratories
1120
1140
...
Keynote
...
The Potential of Using UHPLC-triple Quadrupole Mass Spectrometry to Investigate the O-glycan on Human IgA Hinge Region: Clinical Application to IgA Nephropathy
Isabel I-Lin Tsai
Taipei Medical University
...
Extended Session
...
Mass Spectrometry and Immunofluorescence Imaging for Identifying Metabolic Markers of Immunotherapy Response in Syngeneic Tumor Models
Mary King
The University of Texas at Austin
Data-analysis Process for Multiplexed Mass Spectrometry-based Protein Assays
Irene van den Broek
Cedars-Sinai Precision Biomarker Laboratories
...
Extended Session
...
1140
1200
...
Keynote
...
Ultrahigh Resolution MS Profiling of Plasma N-glycans in Large Type 2 Diabetes Cohorts
Elham Memarian
Leiden University Medical Center
...
Extended Session
...
MALDI FTICR MS Imaging and Quantitative Lipidyzer Approach to Investigate Total Parkinson Disease Lipidome and Circulating Lipidomic Biomarkers of PD
E. Ellen Jones
NCTR / FDA
Deep Learning for Prediction and Prospective Validation of Functional Groups for Autonomous Instrumentation
Gaurav Chopra
Purdue University
...
Extended Session
...
1200
1315
Lunch
@ Exhibit Hall

Enjoy perusing the exhibits and posters while grazing on the Farmer's Produce Stand lunch buffet.

Scientific Session 7

Track 1
Room 1

TBA
Chair: TBA

Track 2
Room 2

Metabolomics Keynote: Theodore Alexandrov
Chair: TBA

Track 3
Room 3

TBA
Chair: TBA

Track 4
Room 4

New Imaging Hardware/Technology
Chair: Christopher Anderton (pending)
2nd Chair: Wojciech Michno (pending)

Track 5
Room 5

Monoclonal Ab Therapeutics and MS
Chair: Paula Ladwig (pending)

Track 6
Room 6

Practical Training
Chair: Russ Grant (pending)
2nd Chair: Grace van der Gugten (pending)

1315
1335
TBA Spatial Metabolomics: From Big Data to Single Cells
Theodore Alexandrov
European Molecular Biology Laboratory
TBA Development of <i>in vivo</i> Real-time Molecular Topological Imaging of Cancer Using SpiderMass
Isabelle Fournier
Université De Lille, Inserm, U1192
MS Quantitation and/or Screening of Monoclonal Antibody Therapeutics: the Good, the Bad, the Ugly
Paula Ladwig
Mayo Clinic
Transition Ratio Monitoring for the Masses ... or When to Tell that Your Mass Spectrometer is Lying to You
Russ Grant
Labcorp
1335
1355
TBA...
Keynote
...
TBA A Multi-modal Analysis on Cancer Research Using DESI-MSI, LC-MS, and RNA-seq with Laser Capture Microdissection
Emine Kazanc
Imperial College of London
...
Extended Session
...
...
Extended Session
...
1355
1415
TBA...
Keynote
...
TBA Characterizing Spatial-Temporal Abeta Plaque Aggregation Dynamics in Evolving AD Pathology Using iSILK
Wojciech Michno
Sahlgrenka Academy at the University of Gothenburg
...
Extended Session
...
...
Extended Session
...
1315
1415

Exhibitor Feedback Meeting
Exhibitors, please have at least one representative attend this important opportunity to shape the future editions of MSACL.

1415
1530
Exhibits & Poster Session
@ Exhibit Hall

Odd 'b' poster positions to be attended. Poster Finalists to attend their posters for final interviews.
1515
1530
Remove Posters
@ Exhibit Hall

You can store your poster at the Reg Desk until 20:00.
1530
Exhibits Closed
@ Exhibit Hall

Scientific Session 8

Track 1
Room 1

Practical Training
Chair: Shannon Haymond (pending)
2nd Chair: Judy Stone (pending)

Track 2
Room 2

New Applications and Strategies
Chair: Livia Eberlin (pending)
2nd Chair: Anand Mehta (pending)

Track 3
Room 3

Keynote: Catherine Costello
Chair: TBA

Track 4
Room 4

Closed
Chair: TBA

Track 5
Room 5

Closed
Chair: TBA

Track 6
Room 6

Closed
Chair: TBA

1530
1550
Working with R for Validation Summaries in the Clinical Laboratory
Lindsay Bazydlo
University of Virginia
Simultaneous MS Imaging of Multiple Brain Signaling Molecules and Alterations Induced by Parkinsonism and L-DOPA Therapy
Per Andren
Uppsala University
TBA
CLOSED

CLOSED

CLOSED
1550
1610
Putting R Skills to Use in Clinical Laboratories
Dustin Bunch
Northwestern University Feinberg School Medicine
An In-situ Single Cell Atlas of the Terminal Bronchioles in Chronic Obstructive Pulmonary Disease by Imaging Mass Cytometry
Steve Booth
Center for Heart Lung Innovation, Ubc
TBA
CLOSED

CLOSED

CLOSED
1610
1630
No Middleware? No Problem. Using R and Shiny for Routine Review of QC Data and Other Quality Metrics
Dennis Orton
Alberta Precision Laboratories
Molecular Diagnostics of Esogastric Cancer with SpiderMass Real-time Analysis: A Step Closer to in vivo Application
Nina Ogrinc
Laboratory Prism, University of Lille
TBA
CLOSED

CLOSED

CLOSED
1630
1645
Plenary Reception
@ Ballroom Foyer
1645
1700
Poster Awards
@ Rooms 4-6

Join us in congratulating the winners of the poster contest.
1700

Plenary Lecture


@ Rooms 4-6

1700
1745
Brain Organoids as a Model System for Human Neurodevelopment and Evolution
Alysson Muotri
University of California, San Diego

Structural and transcriptional changes during early brain maturation follow fixed developmental programs defined by genetics. However, whether this is true for functional network activity remains unknown, primarily due to experimental inaccessibility of the initial stages of the living human brain. We developed cortical organoids that spontaneously display periodic and regular oscillatory network events that are dependent on glutamatergic and GABAergic signaling. These nested oscillations exhibit cross-frequency coupling, proposed to coordinate neuronal computation and communication. As evidence of potential network maturation, oscillatory activity subsequently transitioned to more spatiotemporally irregular patterns, capturing features observed in preterm human electroencephalography (EEG). These results show that the development of structured network activity in the human neocortex may follow stable genetic programming, even in the absence of external or subcortical inputs. Our approach provides novel opportunities for investigating and manipulating the role of network activity in the developing human cortex. Applications for neurodevelopmental disorders and brain evolution will be discussed.

1745
1800
Final Remarks
@ Rooms 4-6

The Scientific Committee Chair and Vice Chair wrap up the week and share information about upcoming Conferences.
1800
2000
Closing Dinner
@ Chiki Pool

A final seated meal and opportunity to relax into the evening.
1930
2200
Hospitality Lounge
@ Gypsy Rose

Friday

Scientific Session 9

Track 1
Room 1

Imaging Mass Spectrometry Society Special Session
Chair: TBA

Track 2
Room 2

TBA
Chair: TBA

Track 3
Room 3

TBA
Chair: TBA

Track 4
Room 4

TBA
Chair: TBA

Track 5
Room 5

TBA
Chair: TBA

Track 6
Room 6

TBA
Chair: TBA

800
820
TBA
CLOSED

CLOSED

CLOSED

CLOSED

CLOSED
820
840
TBA
CLOSED

CLOSED

CLOSED

CLOSED

CLOSED
840
900
TBA
CLOSED

CLOSED

CLOSED

CLOSED

CLOSED
830
1030

Scientific Committee Leads 2021 Planning Meeting
Closed meeting for SciCom Leads and Admin to prepare for 2021!

1200
Conference Closed
@ Ballroom Foyer