Judy Stone (Presenter)
Univ. of Calif. San Diego Health System
Bio: Judy Stone, Ph.D., MT(ASCP), DABCC Judy worked as a CLS in San Jose, CA and then obtained her doctorate in Clinical Biochemistry at the University of Toronto. Her fellowship in Clinical Chemistry was at the University of Minnesota Hospital & Clinics. She has since served as Asst. Professor and Assoc. Director of Clinical Chemistry at the University of Connecticut Health Center, as Asst. Professor and Director of the Core, Immunology and Toxicology Laboratories at the University of Massachusetts Medical Center; and worked with mass spectrometry at Specialty Laboratories, San Francisco General Hospital and Kaiser Regional Laboratories in Northern California. She is currently Senior Technical Specialist in the Clinical Mass Spectrometry Laboratory, Center for Advanced Laboratory Medicine, Univ. of Calif. San Diego Health System. Her research interest is in mass spectrometry application
Authorship: Stone JA (1), Hochrein H (1) Akin J (1), Pratico K (1), Fitzgerald RL (1,2).
(1) University of Calif. San Diego Health System, Center for Advanced Laboratory Medicine (2) Department of Pathology
| Short Abstract It is a common complaint that LC problems occur more frequently than MSMS problems in the clinical mass spectrometry laboratory. Poor chromatography for early eluting analytes, caused by guard and column aging or sample preparation errors, is encountered fairly often. Occasionally bizarre peak shapes or missing peaks only at the end of the run is observed, potentially LC pump or mobile phase related. Acceptable chromatography at both the beginning and end of the run with missing peaks in the middle of the run is a more interesting situation to troubleshoot. We describe the presentation and resolution of such a case. |
Long Abstract
It is a common complaint that LC problems occur more frequently than MSMS problems in the clinical mass spectrometry laboratory. Poor chromatography for early eluting analytes, caused by guard and column aging or sample preparation errors, is encountered fairly often. Occasionally bizarre peak shapes or missing peaks only at the end of the run is observed, potentially LC pump or mobile phase related. Acceptable chromatography at both the beginning and end of the run with missing peaks in the middle of the run is a more interesting situation to troubleshoot. We describe the presentation and resolution of such a case.
References & Acknowledgements:
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IP Royalty: no
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