MSACL 2016 US Abstract

Mass Spectrometry in Clinical Science

R Graham Cooks (Presenter)
Purdue University

Bio: Cooks research work is focused on mass spectrometry. He was a pioneer in the conception and implementation of tandem mass spectrometry (MS/MS) and of desorption ionization, especially molecular secondary ionization mass spectrometry (SIMS). His group designed and built mass spectrometers of various types, including miniature portable mass spectrometers, and applied them to problems of trace chemical detection in environmental, clinical, and bioanalytical areas. Some inventions and concepts to which Graham Cooks contributed are ion soft landing, neutral loss scans, matrix based ionization, multiple reaction monitoring, hybrid mass spectrometers, handheld mass spectrometers, the kinetic method of thermochemical determination, and tissue imaging for medical diagnosis.

Authorship: R. Graham Cooks, Karen E Cesafsky, Alan K. Jarmusch, Valentina Pirro, Christina Ferreira, Fernanda Bertuccez Cordeiro, Zheng Ouyang
Department of Chemistry, School of Biomedical Engineering, and Center for Analytical Instrumentation Development, Purdue University, West Lafayette, IN 47907

Short Abstract This presentation attempts to elucidate the forces converging to create a major increase in the applications (and applicability) of mass spectrometry in the clinic. The forces include: i) ambient ionization methods for direct examination of biological samples, including tissue and whole biofluids, ii) miniature mass spectrometers capable of unit resolution and MS/MS, iii) ion transfer over long distances to the Mini MS iv) quantitation out of complex mixtures by multiple reaction monitoring (MRM), and v) multivariate data analysis for confident assignment of complex spectral patterns to particular biological and disease states. Example applications include surgical margins, drug and microorganism (e.g. strep) detection.

Long Abstract

This presentation attempts to elucidate the forces converging to create a major increase in the applications (and applicability) of mass spectrometry in the clinic. The forces include: i) ambient ionization methods for direct examination of biological samples, including tissue and whole biofluids, ii) miniature mass spectrometers capable of unit resolution and MS/MS, iii) ion transfer over long distances to the Mini MS iv) quantitation out of complex mixtures by multiple reaction monitoring (MRM), and v) multivariate data analysis for confident assignment of complex spectral patterns to particular biological and disease states. Example applications include surgical margins, drug and microorganism (e.g. strep) detection.

References & Acknowledgements:

Financial Disclosure

IP Royalty: yes

IP Desc:Miniature mass spectrometers

Planning to mention or discuss specific products or technology of the company(ies) listed above:

no