MSACL 2017 EU Abstract

System Suitability Tests Part 2: Troubleshooting Common Issues

Michael Wright (Presenter)
LGC, Drug Development Services

Bio: Mike is a principal scientist overseeing method development projects and driving scientific strategy for the Drug Development Services division at LGC. Over the past 17 years Mike has worked with quantitative HPLC and Mass Spectrometry services within CRO, hospital and university laboratory sectors both in the UK and in Australia. With a focus on biomarkers, he has been involved in the development of clinical assays for the fields of new-born screening, gastro-intestinal permeability, the investigation of metabolic disease, endocrinology and therapeutic drug monitoring.

Authorship: Mike Wright
LGC, Fordham, UK

Short Abstract

Having set the scene on establishing System Suitability Tests (SST) the focus is now on what to do when the SST fails. Starting from the presentation of symptoms displayed by the SST chromatogram, through the process of determining the next troubleshooting experiments to be run, and finally to the diagnosis and treatment of the problem, it will soon become apparent why many call the SST "the Doctor".

Long Abstract

References & Acknowledgements:

Financial Disclosure

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