MSACL 2017 EU Abstract

How to Achieve Lower Quantification Limits

Russell Grant (Presenter)
Laboratory Corporation of America

Short Abstract

This one hour session will be given as three 20 minute linked vignettes and will explore established and novel approaches to definitively improve analytical measurement performance - with the end goal of improving assay LLOQ. Part 1 "Foundations": Basis of LLOQ, signal:noise, lossless systems, and practically determining and improving measurement precision. Part 2 "Formulation": Getting the most out of your assay and system components, LC and preparative orthogonality and demystifying the black box after the LC via signal manipulation, smoothing and quadrupole resolution. Part 3 "Finesse": Tying the pieces together with assay exemplars.

Long Abstract

This one hour session will be given as three 20 minute linked vignettes and will explore established and novel approaches to definitively improve analytical measurement performance - with the end goal of improving assay LLOQ.

Part 1 "Foundations": Basis of LLOQ, signal:noise, lossless systems, and practically determining and improving measurement precision.

Part 2 "Formulation": Getting the most out of your assay and system components, LC and preparative orthogonality and demystifying the black box after the LC via signal manipulation, smoothing and quadrupole resolution.

Part 3 "Finesse": Tying the pieces together with assay exemplars.


References & Acknowledgements:


Financial Disclosure

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IP Royalty: no

Planning to mention or discuss specific products or technology of the company(ies) listed above:

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