= Emerging. More than 5 years before clinical availability. |
= Expected to be clinically available in 1 to 4 years. |
= Clinically available now. |
Topic: Practical Training
Authors: Brian Rappold
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Short Abstract The second of 3 lectures on improving instrument response will focus on the approaches and experimentation used in LC-MS/MS assays. Understanding that increased response can only be generated in two phases of the LC-MS/MS process (material loaded into the system and ionization cross-section), a series of examples on scientifically defining “optimization” will be walked through. |
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Long Abstract Introduction The desire to achieve lower limits of detection in LC-MS/MS is universal. In the absence of next generation ionization sources provided at little to no cost to all laboratories, the task of reducing detection thresholds falls to the laboratory scientist. Methods The methods for this lecture may include frantic hand waving, interpretive dance and excessive facial expressions. It will most certainly include talking and power point slides. Results Hopefully, results will provide for lower limits of detection resulting in less sample utilized and more robust assays. Worst case, a few laughs and a refresher on LC-MS/MS fundamentals shall be had. Conclusions & Discussion The most important conclusions shall be drawn by the participants after returning to their laboratory and performing some of the described experiments. Discussion should begin in the lectures, hopefully continuing through the evening and well into the next day. Email correspondence is encouraged post-conference and phone calls would be welcome if made during regular business hours. |
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References & Acknowledgements: I'd like to recognize the organizers of the conference, particularly the Herold family, and the scientific committee of MSACL EU. Additionally, the clinicians, laboratorians, vendors and scientists using LC-MS/MS to make a positive difference in the quality of diagnostic testing deserve a round of applause. I'd also like to thank my wife for her many years of support. |
Description | Y/N | Source |
Grants | no | |
Salary | yes | LabCorp |
Board Member | yes | Metabolomic Diagnostics |
Stock | yes | LabCorp |
Expenses | yes | MSACL |
IP Royalty: no
Planning to mention or discuss specific products or technology of the company(ies) listed above: | no |