= Emerging. More than 5 years before clinical availability. |
= Expected to be clinically available in 1 to 4 years. |
= Clinically available now. |
Topic: Metabolomics
Authors: Christine Hinz (1), Sonia Liggi (1), Julia Denes (1), Antonio Murgia (1, 2), Zoe Hall (1), Ke-di Liu (1), Luigi Atzori (3), John Fjeldsted (4), and Julian L. Griffin (1, 2)
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Short Abstract A major challenge of LC-MS of complex lipid mixtures is the separation/identification of isobaric compounds, which often have similar chromatographic properties, and fragmentation data can be inconclusive. Ion mobility (IM) separates isobaric ions based on their mobilities through an inert gas, with mobility correlated to the collisional cross sections (CCSs) of molecules. Using a combination of samples and standards, and an in-house database based on mass-to-charge ratios, retention times, MS/MS spectra, and CCS values, we have used this workflow to improve the annotation of lipid species and demonstrate its use by analysing adipose tissue in an obese mouse model. |
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Long Abstract Not provided. |
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References & Acknowledgements:
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Description | Y/N | Source |
Grants | no | |
Salary | no | |
Board Member | no | |
Stock | no | |
Expenses | no |
IP Royalty: no
Planning to mention or discuss specific products or technology of the company(ies) listed above: | no |