MSACL 2018 US Abstract

Topic: Practical Training

Method Development Case History Part 3: Re-Development and Re-Validation

Simuli Wabuyele (Presenter)
ARUP Institute for Clinical and Experimental Pathology

Authorship: Simuli L. Wabuyele, Ph.D
ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT

Short Abstract

The development of an effective and robust sample preparation method for analysis of complex biological matrices is critical for LC-MS/MS-based LDTs in the clinical laboratory as it may significantly impact the quality of results and ultimately increase time and cost of analysis. This section of the case history will focus on the re-development of the sample preparation method and LC-MS/MS method improvements for the analysis of a broad range of drugs in a complex biological matrix (i.e., tissue) and the validation of the assay for implementation into routine clinical use.

Long Abstract

Introduction

Methods

Results

Conclusions & Discussion


References & Acknowledgements:


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