MSACL 2018 EU Abstract

Self-Classified Topic Area(s): Small Molecules

Clinical Mass Spectrometry: the Assessment of Acidosis Profiles and Acute Kidney Injury in Severe Malaria

Natthida Sriboonvorakul (1), Sasithon Pukrittayakamee (1), Kesinee Chotivanich (1), Yaowalark Sukthana (2), Stije J. Leopold (3,4), Katherine Plewes (3,4), Nicholas P. J. Day (3,4), Nicholas J. White (3,4), Joel Tarning (3,4) and Arjen M. Dondorp (3,4)*
(1) Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand (2) Department of Protozoology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand (3) Mahidol‑Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand (4) Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.

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Natthida Sriboonvorakul (Presenter)
Mahidol University

Presenter Bio: Dr. Natthida Sriboonvorakul is PhD lecturer in Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University. She has professional interest in Clinical Chemistry research using several advance technologies including analytical separation, chromatography and mass spectrometry. She had experience in clinical mass spectrometry study in malaria disease (Sriboonvorakul, Leepipatpiboon et al. 2013, Herdman, Sriboonvorakul et al. 2015) this research was collaboration with Mahidol Oxford Tropical Medicine research unit and recently, Sriboonvorakul, Ghose et al. 2018 published in Malaria Journal. In 2016, her research title "Clinical Mass Spectrometry: Introduction to kinetic study of acidosis in patients with severe malaria” received best poster award honorable mention in HPLC 2016 Symposium, United States of America.

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Abstract

In severe falciparum malaria acidosis and acute kidney injury (AKI) are independent predictors of a fatal outcome. The relationship between plasma acids, urine acids and renal function was investigated in adult patients with acute falciparum malaria. Clinical mass spectroscopy was utilized for assessment of small organic acid profiles. Plasma and urinary concentrations of selected acids were increased in falciparum malaria patients according to disease severity. Principal component analysis separated a group of patients with AKI and mainly driven by p-hydroxyphenyl lactate (pHPLA) concentrations in both plasma and urine. pHPLA could contribute to acute kidney injury in severe malaria.