MSACL 2018 EU Abstract

Self-Classified Topic Area(s): Proteomics

Validation of ApolipoProtein A-I Associated Lipoprotein Panel for the Prediction of Cholesterol Efflux Capacity

Zhicheng Jin, Timothy S. Collier, Cory Bystrom
Cleveland HeartLab, Cleveland, OH

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Cory Bystrom (Presenter)
Cleveland HeartLab

Relevant Financial Disclosures (within past 24 months, reported on Mar 19, 2025)

Salary Cleveland HeartLab/Quest

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Conflict mitigation NOT REQUIRED.

Abstract

We developed a rapid affinity method to enrich apolipoprotein A-I associated lipoproteins and utilized mass spectrometry-based approach for multiplex quantitation. Utilizing this technique, a multiprotein panel was developed which can be used to estimate cholesterol efflux capacity. The analytical workflow was validated and used in an 8 week longitudinal study. In normal healthy volunteers, predicted cholesterol efflux was stable.