Urinary Biomarkers of Dietary Intake - Quantification of Sugars for Epidemiology Studies Using LC-MS/MS
Nicola Gray. Gunter GC Kuhnle Department of Food and Nutritional Sciences, University of Reading, Reading, UK
Warning: Undefined variable $headshot in /var/www/html/view_abstract/view_abstract_in_program.php on line 704
Nicola Gray (Presenter) University of Reading
Relevant Financial Disclosures
(within past 24 months)
No relevant financial relationship(s) to disclose.
Abstract
For epidemiology studies that aim to investigate how diet influences health, accurate records of nutritional intake are essential. Nutritional assessment typically relies on self-reported food diaries or food-frequency questionnaires, known to be inaccurate and introduce bias. The development of accurate markers to assess dietary intake is therefore crucial to investigate associations between diet, health and disease. For example, urinary sucrose and fructose have been shown to correlate with total sugars intake and have been developed as a marker of sugar consumption. The application of such a biomarker to population studies require robust methods suitable for high-throughput analysis. Here, an LC-MS/MS method has been developed to distinguish and quantify sugars in urine for application to large clinical cohorts as an accurate measure of sugars consumption in free-living populations.
= Discovery stage.
= Translation stage.
= Clinically available.
