Mass Spectrometry Applied to Large-Scale Multi-Centre Clinical Project in Breath Research
Belluomo I (1), Woodfield G (1,2), Waller A (1), Doran S (1,2), Lin G (1), Ayrton O (1), Romano A (1), Hanna GB (1,2) 1) Imperial College London 2) Imperial College Healthcare NHS Trust
Warning: Undefined variable $headshot in /var/www/html/view_abstract/view_abstract_in_program.php on line 704
Ilaria Belluomo (Presenter) Imperial College London
Presenter Bio: I am currently a post-doc scientist at the Surgery and Cancer division of the Imperial College London in the team of Professor George Hanna. The main interest of the research team is volatile organic compounds analysis in human breath and biofluids with different mass spectrometry techniques. Since few months, I am the senior scientist and I am directly responsible of the scientific and organizational management of the whole team. Before starting my postdoc in London, I have been working in Bologna (Italy) and in Bordeaux (France). My PhD has been carried out between these two countries, as part of the international program “Doctor Europaeus”. Clinical applications of mass spectrometry have always been the common thread in my entire career.
Relevant Financial Disclosures
(within past 24 months, reported on Jul 15, 2021)
No relevant financial relationship(s) to disclose.
Abstract
Non-invasive and rapid diagnostic testing, such as breath testing, is the future of diagnostic medicine. We are establishing a workflow for a multi-centre large-scale clinical project for the diagnosis of colorectal cancer. This involves analysis of breath samples with two different mass spectrometry platforms, requiring reliability and a strong quality control system. The use of two different but complementary technologies and the three levels of quality control for this large-scale screening increased sensitivity, specificity and reliability of the results. Thanks to our multi-instrument platform and three different levels of quality control, we have an accurate, specific and sensitive method for determining volatile organic compounds profile in human breath.
= Discovery stage.
= Translation stage.
= Clinically available.
