MSACL 2018 EU Abstract

Shotgun Lipidomics of Cerebrospinal Fluid in Neurological Disorders

Mária Péter (1), Magdolna Pákáski (2), Anna Petrovics-Balog (3), Zita Oláh (2), Zsolt Datki (2), Eszter Ivitz (2), Wanda Török (3), Tibor Kovács (4), Dénes Zádori (3), János Tajti (3), Péter Klivényi (3), Ibolya Horváth (1), János Kαlmαn (2), László Vécsei (3,5), László Vígh (1), Gábor Balogh (1
(1) Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary; (2) Department of Psychiatry, University of Szeged, Szeged, Hungary; (3) Department of Neurology, University of Szeged, Szeged, Hungary; (4) Department of Neurology, Semmelweis University, Budapest, Hungary; (5) MTA-SZTE Neuroscience Research Group, University of Szeged, Szeged, Hungary.

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Gábor Balogh (Presenter) Biological Research Centre, Hungarian Academy of Sciences

Presenter Bio: Received PhD in biochemistry at the Cardiff University, senior staff member of the Laboratory of Molecular Stress Biology and manage the Lipidomics Research Group in the Biological Research Center, Szeged. Research interests are development and application of lipidomics techniques and information technology solutions in the areas of lipidomics. He has broad experience in mass spectrometry of lipids, membrane and lipid biochemistry and biophysics, lipids in membrane function and signal transduction. Has 46 publications and over 1900 citations.

Relevant Financial Disclosures (within past 24 months) No relevant financial relationship(s) to disclose. Discussing Products? NO, presenter will NOT present educational content related to products/services of the ineligible company(ies) listed above. Conflict mitigation NOT REQUIRED.

Biomarkers are urgently needed to improve diagnosis and prognosis of neurodegenerative diseases. Here we demonstrate that the lipid composition of cerebrospinal fluid (CSF) from Multiple Sclerosis, Alzheimer's disease (AD) and Guillain–Barré syndrome (GBS) patients shows significant signs of metabolic disturbances. In AD patients we found several lipid markers which were indicative to the severity of dementia, while the shift observed in the lipid profile of GBS patients supports the hypothesis of leakage from blood through the blood-nerve barrier. Therefore, lipidomic analysis of CSF might capable to reflect the pathophysiology of several neurological disorders.