MSACL 2018 EU Abstract

Self-Classified Topic Area(s): Practical Training

1/3 Getting Lower Limits of Quantification in LC-MS/MS assays : Prologue

Brian Rappold
Laboratory Corporation of America

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Brian Rappold (Presenter)
LabCorp

Presenter Bio: Brian Rappold is the Director of Mass Spectrometry for LabCorp. He's participated in MSACL EU since its inception, leading workshops and teaching short courses related to method development and validation strategies.

Relevant Financial Disclosures (within past 24 months, reported on Jul 14, 2021)

Honorarium/Expenses MSACL

Committee/Board/Advisory Board Metabolomic Diagnostics

Stock/Bonds LabCorp

Salary LabCorp

Discussing Products? NO, presenter will NOT present educational content related to products/services of the ineligible company(ies) listed above.

Conflict mitigation NOT REQUIRED.

Abstract

Understanding mechanisms to achieving better sensitivity in LC-MS/MS assays must start with fundamentals and first principles of the technology. An initial conversation of noise, response functions, ionization techniques and hardware will introduce attendees to the basics of mechanisms used to reduced needed sample volume, increase instrument response and improve assay precision.