MSACL 2018 EU Abstract

Self-Classified Topic Area(s): Practical Training

2/3 Getting Lower Limits of Quantification in LC-MS/MS assays : Phases and Stages

Brian Rappold
Laboratory Corporation of America

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Brian Rappold (Presenter)
LabCorp

Presenter Bio: Brian Rappold is the Director of Mass Spectrometry for LabCorp. He's participated in MSACL EU since its inception, leading workshops and teaching short courses related to method development and validation strategies.

Relevant Financial Disclosures (within past 24 months, reported on Apr 09, 2026)

Honorarium/Expenses MSACL

Committee/Board/Advisory Board Metabolomic Diagnostics

Stock/Bonds LabCorp

Salary LabCorp

Discussing Products? NO, presenter will NOT present educational content related to products/services of the ineligible company(ies) listed above.

Conflict mitigation NOT REQUIRED.

Abstract

The second of 3 lectures on improving instrument response will focus on the approaches and experimentation used in LC-MS/MS assays. Understanding that increased response can only be generated in two phases of the LC-MS/MS process (material loaded into the system and ionization cross-section), a series of examples on scientifically defining “optimization” will be walked through.