A Pilot Study Profiling Volatile Organic Compounds (VOCs) in the Breath of Patients with CRC Using Proton Transfer Mass Spectrometry
Harrypal Panesar Imperial College London
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Harrypal Panesar (Presenter) Imperial College London
Presenter Bio: I am a final year medical student at the University of Liverpool. Recently, I completed an intercalation year at Imperial College London which was largely research based. At Imperial I undertook a project in the field of Metabolomics, specifically breath testing in colorectal cancer. My interests are in the field of surgery and using Metabolomics to enhance current practice.
Relevant Financial Disclosures
(within past 24 months)
No relevant financial relationship(s) to disclose.
Abstract
We initially asked the question: Is it possible to distinguish between health patients and those with colorectal cancer (CRC) using their breath profiles? Previous research has suggested differences in VOC profile between health and CRC patients using Selected Ion Flow Tube Mass Spectrometry (SIFT-MS). However, we employed a new technique, Proton Transfer Mass Spectrometry (PTR-MS), to measure the VOC profile in the breath of CRC and healthy patients. Analysing the breath profile of 17 patients with CRC and comparing them to normal colons, we describe a profile of breath VOCs that are significantly different between normal and CRC patients.
= Discovery stage.
= Translation stage.
= Clinically available.
