MSACL 2019 EU Abstract

Self-Classified Topic Area(s): Practical Training

Traceable Clinical Measurement

Chris Hopley
NML, Queens Road, Teddington, Middlesex, UK

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Chris Hopley (Presenter)
NML

Presenter Bio: Chris Hopley is a Principal Scientist working in the National Measurement Laboratory, UK, with Line/Technical Management of a team of 10 people. He has over 20 years MS spectrometry research experience, with a particular focus on instrumental performance, for both qualitative and quantitative applications, for small molecule applications. He specializes in measurements traceable to the SI. He is a co-author on 25 peer review articles with 300 combined citations.

Relevant Financial Disclosures (within past 24 months)

Grant/Research Support Mr.

Committee/Board/Advisory Board British Mass Spectrometry Society

Salary LGC

Discussing Products? YES, presenter will present educational content related to products/services of one or more ineligible company(ies) listed above.

Conflict mitigation IN PROCESS.

Abstract

This is a practical training session describing the process of certifying traceable reference materials and/or traceable reference values of analytes in a clinical matricies, with a defined uncertainty. This work is routinely carried out at the NML to provide traceable values to materials listed on the JCTLM database, and also to provide traceable reference values to clinical materials.
The workshop will include descriptions of optimisation of measurement, traceability, uncertainty and example workflows for targets such as creatinine, immuno-suppressants (sirolimus and tacrolimus) and metanephrines. It is hoped participants will gain an insight into the work of the NML and the requirements for traceable clinical measurement. There will also be a brief discussion at the end of the workshop on the requirements for future materials.

3 take home pearls
How to maintain traceability to the SI in clinical reference measurement
Uncertainty calculations for traceable measurement
Examples of pitfalls encountered during the certification process