MSACL 2019 US Abstract

Mass Spectrometry: Applications to the Hospital Blood Bank

Joesph R. Wiencek (1), Eric A. Gehrie (2), Amaris M. Keiser, (2), Penny C. Szklarski (3), Kamisha L. Johnson-Davis, PhD (4)(5), Garrett S. Booth (3)
(1) University of Virginia, Charlottesville, Va (2) Johns Hopkins University, Balitmore, MD (3) Vanderbilt University Medical Center, Nashville, TN (4) ARUP Institute for Clinical and Experimental Pathology (5) University of Utah Health Sciences Center

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Joesph Wiencek (Presenter) University of Virginia School of Medicine

Presenter Bio: Joesph R. Wiencek received his undergraduate and graduate degrees from The Ohio State University and Cleveland State University, respectively. Following this, he completed his Clinical Chemistry Fellowship in the Department of Pathology, Microbiology and Immunology at Vanderbilt University Medical Center. Currently, Dr. Wiencek is an Assistant Professor of Pathology at the University of Virginia School of Medicine. He also serves as the Director of Biochemical Genetics, Director of Immunology, and Associate Director of Clinical Chemistry for the UVA Health System. His clinical interests revolve around laboratory testing in the areas of pediatric clinical chemistry. He also has research interests in preanalytical variation as well as the use of mass spectrometry for elucidating interferences in laboratory testing and its use in underexplored areas of medicine.

Relevant Financial Disclosures (within past 24 months) No relevant financial relationship(s) to disclose. Discussing Products? NO, presenter will NOT present educational content related to products/services of the ineligible company(ies) listed above. Conflict mitigation NOT REQUIRED.

The Office of the Surgeon General states there is no risk-free concentration of active or passive tobacco exposure. However, little is known regarding the prevalence or concentration of tobacco by-products in the blood supply. In this study, we measured nicotine and its metabolites in 105 RBC units by LC-MS/MS to estimate the point prevalence of exposure within the healthy donor pool. Twenty units (19%) contained concentrations of either nicotine, or nicotine metabolites. These findings have never been disclosed by the blood collection industry and to the best of our knowledge, this would be the first-report associated with the general inventory.