MSACL 2019 US Abstract

Self-Classified Topic Area(s): Practical Training

A Survey of Mass Spectrometry Quality Assurance Practices in Clinical Laboratories

Joshua Hayden (1), Danyel Tacker (2), Grace van der Gugten (3), Gabrielle Winston-McPherson (4), Lorin Bachmann (5)
(1) Weill Cornell Medicine, (2) West Virginia University Medicine, (3) St. Paul's hospital, (4) University of Washington, (5) Virginia Commonwealth University Health System

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Joshua Hayden (Presenter)
Norton Healthcare

Relevant Financial Disclosures (within past 24 months)

Honorarium/Expenses Roche

Discussing Products? NO, presenter will NOT present educational content related to products/services of the ineligible company(ies) listed above.

Conflict mitigation NOT REQUIRED.

Abstract

Limited guidance is available on best practices for implementation of quality assurance (QA) monitoring of liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays. No aggregated information is available on QA approaches employed in clinical laboratories. This session will discuss a recent survey that queried the QA practices of clinical laboratories analyzing 25-hydroxyvitamin D by LC-MS/MS. The session will include an overview of existing professional practice guidelines for LC-MS/MS assay QA monitoring including: ion ratio monitoring, internal standard recoveries and chromatographic characteristics. The specific strategies reported by various laboratories for applying QA programs will be the focus of the discussion. Attendees should leave this session with a better understanding of approaches for implementation of QA metrics and gain insights they can apply in their labs.